The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
AMAG PHARMACEUTICALS INC COM 00163U106 115 2,904 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC COM 00182C103 761 19,256 SH   SOLE   0 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 6,923 7,500,000 PRN   SOLE   0 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 7,140 1,762,881 SH   SOLE   0 0 0
ABEONA THERAPEUTICS INC *W EXP 12/19/201 00289Y115 2,173 1,259,636 SH   SOLE   0 0 0
ACADIA PHARMACEUTICALS INC COM 4225108 9,764 295,240 SH   SOLE   0 0 0
ACASTI PHARMA INC CL A SHS 00430K105 626 2,365,600 SH   SOLE   0 0 0
ACCELERON PHARMA INC COM 00434H108 6,873 276,036 SH   SOLE   0 0 0
ACHAOGEN INC COM 4449104 346 60,000 SH   SOLE   0 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 19,105 6,264,060 SH   SOLE   0 0 0
ADDUS HOMECARE CORP COM 6739106 237 7,601 SH   SOLE   0 0 0
AETNA INC NEW COM 00817Y108 283 2,586 SH   SOLE   0 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 2,512 260,000 SH   SOLE   0 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 5,580 957,193 SH   SOLE   0 0 0
ALLIQUA BIOMEDICAL INC COM NEW 19621200 6,092 1,921,951 SH   SOLE   0 0 0
AMGEN INC COM 31162100 177 1,280 SH   SOLE   0 0 0
AMICUS THERAPEUTICS INC COM 03152W109 175,633 14,439,444 SH   SOLE   0 0 0
AMPLIPHI BIOSCIENCES COM 03211P202 316 80,000 SH   SOLE   0 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 03674U201 5,206 992,156 SH   SOLE   0 0 0
ANTHEM INC COM 36752103 201 1,436 SH   SOLE   0 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 5,591 850,992 SH   SOLE   0 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 839 59,600 SH   SOLE   0 0 0
ARDELYX INC COM 39697107 5,460 315,955 SH   SOLE   0 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 2,628 450,000 SH   SOLE   0 0 0
ARNO THERAPEUTICS INC COM 42564203 712 2,034,721 SH   SOLE   0 0 0
ASSEMBLY BIOSCIENCES INC COM 45396108 7,600 795,000 SH   SOLE   0 0 0
AVINGER INC COM 53734109 1,434 97,500 SH   SOLE   0 0 0
BAXTER INTL INC COM 71813109 1,971 60,000 SH   SOLE   0 0 0
BELLICUM PHARMACEUTICALS INC COM 79481107 7,572 521,188 SH   SOLE   0 0 0
BIOCRYST PHARMACEUTICALS COM 09058V103 1,411 123,745 SH   SOLE   0 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 8,629 404,404 SH   SOLE   0 0 0
BOVIE MEDICAL CORP COM 10211F100 322 162,700 SH   SOLE   0 0 0
BRAINSTORM CELL THERAPEUTICS COM 10501E201 916 400,000 SH   SOLE   0 0 0
CIGNA CORPORATION COM 125509109 2,629 19,470 SH   SOLE   0 0 0
CAMBREX CORP COM 132011107 186 4,692 SH   SOLE   0 0 0
CAPITAL SR LIVING CORP COM 140475104 11,100 553,600 SH   SOLE   0 0 0
CAPRICOR THERAPEUTICS INC COM 14070B101 16 4,000 SH   SOLE   0 0 0
CARDINAL HEALTH INC COM 14149Y108 198 2,574 SH   SOLE   0 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 2,554 851,200 SH   SOLE   0 0 0
CELLECTIS S A SPONSORED ADS 15117K103 5,764 218,679 SH   SOLE   0 0 0
CELYAD SA ADR 151205200 3,139 75,000 SH   SOLE   0 0 0
CEMPRA INC COM 15130J109 16,217 582,500 SH   SOLE   0 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 1,993 372,597 SH   SOLE   0 0 0
CIDARA THERAPEUTICS INC COM 171757107 9,449 742,858 SH   SOLE   0 0 0
COGENTIX MED INC COM 19243A104 835 673,257 SH   SOLE   0 0 0
CONATUS PHARMACEUTICALS INC COM 20600T108 2 425 SH   SOLE   0 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 195 10,379 SH   SOLE   0 0 0
CORBUS PHARMACEUTICALS INC COM 21833P103 1,962 1,250,000 SH   SOLE   0 0 0
CREDIT SUISSE NASSAU BRH INVRS VIX STERM 22542D795 1,132 46,500 SH   SOLE   0 0 0
CURIS INC COM 231269101 202 100,000 SH   SOLE   0 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 10,916 306,715 SH   SOLE   0 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 1,698 360,584 SH   SOLE   0 0 0
DERMIRA INC COM 24983L104 11,016 472,000 SH   SOLE   0 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 411 50,000 SH   SOLE   0 0 0
DIVERSICARE HEALTHCARE SVCS COM 255104101 127 12,337 SH   SOLE   0 0 0
DYAX CORP COM 26746E103 31,428 1,646,315 SH   SOLE   0 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 9,109 123,044 SH   SOLE   0 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 213 1,500 SH   SOLE   0 0 0
ENDOLOGIX INC COM 29266S106 71 5,755 SH   SOLE   0 0 0
EVOLENT HEALTH INC CL A 30050B101 2,191 137,289 SH   SOLE   0 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 4,373 284,129 SH   SOLE   0 0 0
GW PHARMACEUTICALS -ADR ADS 36197T103 27,411 300,000 SH Put SOLE   0 0 0
GENVEC INC COM NEW 37246C307 1,423 615,844 SH   SOLE   0 0 0
GILEAD SCIENCES INC COM 375558103 9,819 100,000 SH Put SOLE   0 0 0
GILEAD SCIENCES INC COM 375558103 241 2,457 SH   SOLE   0 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 38,863 921,800 SH   SOLE   0 0 0
GREATBATCH INC COM 39153L106 248 4,391 SH   SOLE   0 0 0
HCA HOLDINGS INC COM 40412C101 198 2,563 SH   SOLE   0 0 0
HEALTH NET INC COM 42222G108 231 3,831 SH   SOLE   0 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 5 1,537 SH   SOLE   0 0 0
IGNYTA INC COM 451731103 16,959 1,931,600 SH   SOLE   0 0 0
INC RESH HLDGS INC CL A 45329R109 290 7,261 SH   SOLE   0 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303 169 20,000 SH   SOLE   0 0 0
INVITAE CORP COM 46185L103 1,817 251,666 SH   SOLE   0 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 899 86,229 SH   SOLE   0 0 0
ISHARES RUSSELL 2000 RUSSELL 2000 ETF 464287655 21,840 200,000 SH Put SOLE   0 0 0
ISHARES TR HDG MSCI GERMN 46434V704 3,290 145,000 SH   SOLE   0 0 0
JUNIPER PHARMACEUTICALS INC COM 48203L107 20 1,736 SH   SOLE   0 0 0
LHC GROUP INC COM 50187A107 265 5,917 SH   SOLE   0 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 18,189 654,515 SH   SOLE   0 0 0
LANNET INC COM 516012101 168 4,048 SH   SOLE   0 0 0
LIFEPOINT HEALTH INC COM 53219L109 179 2,522 SH   SOLE   0 0 0
LION BIOTECHNOLOGIES INC COM 53619R102 17,023 2,955,456 SH   SOLE   0 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,219 336,287 SH   SOLE   0 0 0
MAGELLAN HEALTH INC COM NEW 559079207 189 3,410 SH   SOLE   0 0 0
MINVERA NEUROSCIENCES COM 603380106 4,255 810,537 SH   SOLE   0 0 0
MOLINA HEALTHCARE INC COM 60855R100 199 2,888 SH   SOLE   0 0 0
MYRIAD GENETICS INC COM 62855J104 94 2,500 SH   SOLE   0 0 0
NANOSPHERE INC COM NEW 63009F204 58 35,379 SH   SOLE   0 0 0
NEOS THERAPEUTICS INC COM 64052L106 7,796 371,066 SH   SOLE   0 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 7,370 6,700,444 SH   SOLE   0 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 117,101 2,942,967 SH   SOLE   0 0 0
NEVRO CORP COM 64157F103 28,150 606,811 SH   SOLE   0 0 0
NIVALIS THERAPEUTICS INC COM 65481J109 1,621 125,000 SH   SOLE   0 0 0
NOVO-NORDISK A S ADR 670100205 290 5,340 SH   SOLE   0 0 0
NOVO-NORDISK A/S-SPONS ADR ADR 670100205 10,848 200,000 SH Put SOLE   0 0 0
NUVASIVE INC COM 670704105 12 252 SH   SOLE   0 0 0
ONCOTHYREON INC COM 682324108 1,380 3,546,897 SH   SOLE   0 0 0
OTONOMY INC COM 68906L105 364 185,368 SH   SOLE   0 0 0
PTC THERAPEUTICS INC COM 69366J200 26,834 1,005,000 SH Put SOLE   0 0 0
PTC THERAPEUTICS INC COM 69366J200 2,670 100,000 SH Call SOLE   0 0 0
PFENEX INC COM 717071104 14,575 971,043 SH   SOLE   0 0 0
PHARMERICA CORP COM 71714F104 194 6,800 SH   SOLE   0 0 0
POWERSHS DB US DOLLAR INDEX DOLL INDX BULL 73936D107 1,381 55,000 SH   SOLE   0 0 0
PROSHARES TR PSHS ULTSH 20YRS 74347B201 520 12,000 SH   SOLE   0 0 0
PROSHARES ULTRA S & P500 PSHS ULT S&P 500 74347R107 11,120 200,000 SH Put SOLE   0 0 0
PROTEON THERAPEUTICS INC COM 74371L109 3,825 275,000 SH   SOLE   0 0 0
PSIVIDA CORP COM 74440J101 257 315,000 SH   SOLE   0 0 0
RECRO PHARMA INC COM 75629F109 145 12,063 SH   SOLE   0 0 0
REGENXBIO INC COM 75901B107 17,166 779,213 SH   SOLE   0 0 0
RELYPSA INC COM 759531106 4,628 250,000 SH Put SOLE   0 0 0
RELYPSA INC COM 759531106 5,553 300,000 SH Call SOLE   0 0 0
RELYPSA INC COM 759531106 18,287 987,942 SH   SOLE   0 0 0
REPLIGEN CORP COM 759916109 2,785 100,000 SH Put SOLE   0 0 0
REPROS THERAPEUTICS INC COM NEW 76028H209 1,635 220,000 SH   SOLE   0 0 0
RETROPHIN INC COM 761299106 53,629 2,647,080 SH   SOLE   0 0 0
STREETTRACKS SPDR BIOTEC ETF S&P BIOTECH 78464A870 17,119 275,000 SH Put SOLE   0 0 0
STREETTRACKS SPDR BIOTEC ETF S&P BIOTECH 78464A870 6 100 SH Call SOLE   0 0 0
SAGE THERAPEUTICS INC COM 78667J108 847 20,000 SH   SOLE   0 0 0
ST JUDE MED INC COM 790849103 3,251 51,520 SH   SOLE   0 0 0
SAREPTA THERAPEUTICS INC COM 803607100 89,424 2,784,928 SH   SOLE   0 0 0
Sarepta Therapeutics Inc COM 803607100 9,634 300,000 SH Call SOLE   0 0 0
SCYNEXIS INC COM 811292101 1,274 175,000 SH   SOLE   0 0 0
SHIRE PLC SPONSORED ADR 82481R106 8,415 41,000 SH   SOLE   0 0 0
STEMLINE THERAPEUTICS INC COM 85858C107 694 78,603 SH   SOLE   0 0 0
SUCAMPO PHARMACEUTICALS INC CL A 864909106 157 7,905 SH   SOLE   0 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 567 700,000 SH   SOLE   0 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 1,198 226,000 SH   SOLE   0 0 0
TESARO INC COM 881569107 39,368 981,759 SH   SOLE   0 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 9,034 160,000 SH   SOLE   0 0 0
THORATEC CORP COM NEW 885175307 6,327 100,000 SH Call SOLE   0 0 0
THORATEC CORP COM NEW 885175307 5,440 86,000 SH   SOLE   0 0 0
TOKAI PHARMACEUTICALS INC COM 88907J107 5,024 485,338 SH   SOLE   0 0 0
TRANSENTERIX INC COM NEW 89366M201 4,127 1,826,432 SH   SOLE   0 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 391 30,000 SH   SOLE   0 0 0
TRIPLE-S MGMT CORP CL B 896749108 189 10,605 SH   SOLE   0 0 0
VALEANT PHARMACEUTICALS INTERNATIONAL IN COM 91911K102 18 100 SH Call SOLE   0 0 0
VBI VACCINES INC COM 91790E102 8,607 3,260,356 SH   SOLE   0 0 0
VERICEL CORP COM 92346J108 952 351,162 SH   SOLE   0 0 0
VERSARTIS INC COM 92529L102 26,726 2,317,954 SH   SOLE   0 0 0
VITAE PHARMACEUTICALS INC COM 92847N103 2,202 200,000 SH   SOLE   0 0 0
WALGREENS BOOTS ALLIANCE INC COM 931427108 2,933 35,292 SH   SOLE   0 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 189 2,189 SH   SOLE   0 0 0
XENCOR INC COM 98401F105 21,461 1,754,784 SH   SOLE   0 0 0
XENCOR INC COM 98401F105 612 50,000 SH Put SOLE   0 0 0
XENON PHARMACEUTICALS INC COM 98420N105 1,699 205,800 SH   SOLE   0 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 8,290 579,350 SH   SOLE   0 0 0
AXOVANT SCIENCES LTD COM G0750W104 5,297 410,000 SH   SOLE   0 0 0
ICON PLC SHS G4705A100 187 2,631 SH   SOLE   0 0 0
QUOTIENT LTD SHS G73268107 10,347 776,803 SH   SOLE   0 0 0
QUOTIENT LTD *W EXP 10/30/201 G73268123 475 131,251 SH   SOLE   0 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 557 75,000 SH   SOLE   0 0 0
INTEC PHARMA LTD JERUSALEM SHS M53644106 1,960 350,000 SH   SOLE   0 0 0
NEURODERM LTD ORD SHS M74231107 5,581 270,000 SH   SOLE   0 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 213 1,493 SH   SOLE   0 0 0
AFFIMED N V COM N01045108 5,361 868,620 SH   SOLE   0 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 819 62,000 SH   SOLE   0 0 0
UNIQURE NV SHS N90064101 14,116 690,269 SH   SOLE   0 0 0