The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 14,751 653,000 SH   SOLE   653,000 0 0
ACASTI PHARMA INC CL A SHS 00430K105 2,437 2,566,785 SH   SOLE   2,566,785 0 0
ACCELERON PHARMA INC COM 00434H108 10,191 300,000 SH   SOLE   300,000 0 0
ACHAOGEN INC COM 004449104 838 60,000 SH   SOLE   60,000 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 67,384 6,574,060 SH   SOLE   6,574,060 0 0
ACHILLION PHARMACEUTICALS IN COM 00448Q201 2,120 280,000 SH   SOLE   280,000 0 0
AEGERION PHARMACEUTICALS ORD COM 00767E102 3,209 100,000 SH Call SOLE   100,000 0 0
AETNA INC NEW COM 00817Y108 10,646 131,308 SH   SOLE   131,308 0 0
ALLERGAN INC COM 018490102 8,461 50,000 SH   SOLE   50,000 0 0
ALMOST FAMILY INC COM 020409108 104 4,708 SH   SOLE   4,708 0 0
ALLIQUA COM 00771V108 4,196 1,121,951 SH   SOLE   1,121,951 0 0
AMICUS THERAPEUTICS INC COM 03152W109 41,214 12,339,444 SH   SOLE   12,339,444 0 0
AMSURG CORP COM 03232P405 90 1,980 SH   SOLE   1,980 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 9,375 528,776 SH   SOLE   528,776 0 0
ANTHERA PHARMACEUTICALS INC COM NEW 3674U201 1,622 478,456 SH   SOLE   478,456 0 0
APPLIED GENETIC TECHNOL CORP COM 03820J100 3,395 146,978 SH   SOLE   146,978 0 0
AQUINOX PHARMACEUTICALS INC COM 03842B101 1,218 130,000 SH   SOLE   130,000 0 0
ARENA PHARMACEUTICALS INC COM 040047102 176 30,000 SH Put SOLE   30,000 0 0
ARNO THERAPEUTICS COM 42564203 3,621 2,034,721 SH   SOLE   2,034,721 0 0
ARROWHEAD RESH CORP COM NEW 042797209 6,045 422,406 SH   SOLE   422,406 0 0
ATHERSYS INC COM 04744L106 1,077 601,852 SH   SOLE   601,852 0 0
BARD C R INC COM 067383109 97 676 SH   SOLE   676 0 0
BIODELIVERY SCIENCES INTL IN COM 09060J106 8,449 700,000 SH   SOLE   700,000 0 0
BIOTA PHARMACEUTIALS INC COM 090694100 722 253,400 SH   SOLE   253,400 0 0
BIOLINERX LTD SPONSORED ADR 09071M106 345 165,698 SH   SOLE   165,698 0 0
BIOSPECIFICS TECHNOLOGIES CO COM 090931106 100 3,700 SH   SOLE   3,700 0 0
CATALYST PHARM PARTNERS INC COM 14888U101 3,795 1,500,000 SH   SOLE   1,500,000 0 0
CELGENE CORP COM 151020104 43,580 507,488 SH   SOLE   507,488 0 0
CENTENE CORP DEL COM 15135B101 4,537 60,000 SH   SOLE   60,000 0 0
CHAMPIONS ONCOLOGY COM 15870p109 1,625 1,625,744 SH   SOLE   1,625,744 0 0
CHARLES RIV LABS INTL INC COM 159864107 100 1,860 SH   SOLE   1,860 0 0
CHIMERIX INC COM 16934W106 3,241 148,000 SH   SOLE   148,000 0 0
CHINA BIOLOGIC PRODS INC COM 16938C106 107 2,400 SH   SOLE   2,400 0 0
CLOVIS ONCOLOGY INC COM 189464100 452 10,917 SH   SOLE   10,917 0 0
DERMA SCIENCES INC COM PAR $.01 249827502 4,698 406,437 SH   SOLE   406,437 0 0
DURECT CORP COM 266605104 1,651 907,064 SH   SOLE   907,064 0 0
DYAX CORP COM 26746E103 26,022 2,710,598 SH   SOLE   2,710,598 0 0
ENSIGN GROUP INC COM 29358P101 109 3,509 SH   SOLE   3,509 0 0
EPIZYME INC COM 29428V104 1,326 42,602 SH   SOLE   42,602 0 0
EXACT SCIENCES CORP COM 30063P105 15,348 901,250 SH   SOLE   901,250 0 0
EXACTECH INC COM 30064E109 113 4,464 SH   SOLE   4,464 0 0
EXELIXIS INC COM 30161Q104 1,356 400,000 SH Call SOLE   400,000 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 2,333 150,000 SH   SOLE   150,000 0 0
FLAMEL TECHNOLOGIES SA SPONSORED ADR 338488109 12,000 800,000 SH   SOLE   800,000 0 0
GENVEC INC COM NEW 37246C307 2,107 820,000 SH   SOLE   820,000 0 0
GENTIVA HEALTH SERVICES INC COM 37247A102 106 7,052 SH   SOLE   7,052 0 0
HCA HOLDINGS INC COM 40412C101 11,152 197,806 SH   SOLE   197,806 0 0
HEALTH NET INC COM 42222G108 250 6,025 SH   SOLE   6,025 0 0
HERON THERAPEUTICS INC COM 427746102 17,738 1,439,770 SH   SOLE   1,439,770 0 0
HERON THERAPEUTICS INC COM 427746102 2,400 194,785 SH   SOLE   194,785 0 0
HUMANA INC COM 444859102 103 803 SH   SOLE   803 0 0
ICAD INC COM NEW 44934S206 962 150,000 SH   SOLE   150,000 0 0
INCYTE CORP COM 45337C102 1,129 20,000 SH   SOLE   20,000 0 0
INSMED INC COM PAR $.01 457669307 35,964 1,800,000 SH   SOLE   1,800,000 0 0
INTERCEPT INC COM 45845P108 4,733 20,000 SH Put SOLE   20,000 0 0
INTERMUNE INC COM 45884X103 9,272 210,000 SH   SOLE   210,000 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 2,125 45,643 SH   SOLE   45,643 0 0
LIGAND PHARMACEUTICALS INC COM NEW 53220K504 1,734 27,843 SH   SOLE   27,843 0 0
LION BIOTECHNOLOGIES COM 53619R102 19,273 3,011,549 SH   SOLE   3,011,549 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,652 316,459 SH   SOLE   316,459 0 0
MACROGENICS INC COM 556099109 9,383 431,803 SH   SOLE   431,803 0 0
MAGELLAN HEALTH INC COM NEW 559079207 102 1,642 SH   SOLE   1,642 0 0
MCKESSON CORP COM 58155Q103 99 530 SH   SOLE   530 0 0
MEDASSETS INC COM 584045108 101 4,429 SH   SOLE   4,429 0 0
MEDGENICS INC COM NEW 58436Q203 428 55,073 SH   SOLE   55,073 0 0
MEDTRONIC INC COM 585055106 8,289 130,000 SH   SOLE   130,000 0 0
MERGE HEALTHCARE INC COM 589499102 99 43,478 SH   SOLE   43,478 0 0
MOLINA HEALTHCARE INC COM 60855R100 106 2,380 SH   SOLE   2,380 0 0
MYLAN INC COM 628530107 14,566 282,500 SH   SOLE   282,500 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 18,493 6,700,444 SH   SOLE   6,700,444 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 68,262 4,599,867 SH   SOLE   4,599,867 0 0
NEWLINK GENETICS CORP COM 651511107 1,328 50,000 SH Call SOLE   50,000 0 0
ONCOTHYREON INC COM 682324108 949 292,779 SH   SOLE   292,779 0 0
OPHTHOTECH CORP COM 683745103 15,717 371,469 SH   SOLE   371,469 0 0
OREXIGEN THERAPEUTICS INC COM 686164104 1,384 224,000 SH   SOLE   224,000 0 0
OXIGENE INC COM PAR$.001 691828404 982 379,200 SH   SOLE   379,200 0 0
PDL BIOPHARMA INC COM 69329Y104 99 10,183 SH   SOLE   10,183 0 0
PTC THERAPEUTICS INC COM 69366J200 17,559 671,736 SH   SOLE   671,736 0 0
PHARMERICA CORP COM 71714F104 98 3,441 SH   SOLE   3,441 0 0
QUESTCOR PHARMACEUTICALS INC COM 74835Y101 36,996 400,000 SH   SOLE   400,000 0 0
QUINTILES TRANSNATIO HLDGS I COM 74876Y101 100 1,875 SH   SOLE   1,875 0 0
RADNET INC COM 750491102 152 22,975 SH   SOLE   22,975 0 0
RECEPTOS INC COM 756207106 8,733 205,000 SH   SOLE   205,000 0 0
REGADO BIOSCIENCES INC COM 75874Q107 5,839 860,000 SH   SOLE   860,000 0 0
RELYPSA INC COM 759531106 14,509 596,605 SH   SOLE   596,605 0 0
RETROPHIN INC COM 761299106 14,960 1,274,292 SH   SOLE   1,274,292 0 0
SANGAMO BIOSCIENCES INC COM 800677106 12,216 800,000 SH   SOLE   800,000 0 0
SAREPTA THERAPEUTICS INC COM 803607100 76,217 2,558,478 SH   SOLE   2,558,478 0 0
SHIRE PLC SPONSORED ADR 82481R106 21,194 90,000 SH   SOLE   90,000 0 0
SMITH & NEPHEW PLC SPDN ADR NEW 83175M205 2,050 22,963 SH   SOLE   22,963 0 0
SPECTRANETICS CORP COM 84760C107 5,568 243,354 SH   SOLE   243,354 0 0
STEMCELLS INC COM NEW 85857R204 551 271,600 SH   SOLE   271,600 0 0
SUNSHINE HEART INC COM 86782U106 140 25,000 SH   SOLE   25,000 0 0
SYMMETRY MED INC COM 871546206 99 11,148 SH   SOLE   11,148 0 0
TESARO INC COM 881569107 19,816 636,956 SH   SOLE   636,956 0 0
TESARO INC COM 881569107 3,111 100,000 SH Put SOLE   100,000 0 0
TRANSGENOMIC INC COM NEW 89365K305 687 183,957 SH   SOLE   183,957 0 0
TRANSENTERIX INC COM NEW 89366M201 6,552 1,300,000 SH   SOLE   1,300,000 0 0
TREVENA INC COM 89532E109 4,351 770,000 SH   SOLE   770,000 0 0
TRIPLE-S MGMT CORP CL B 896749108 105 5,880 SH   SOLE   5,880 0 0
UNIVERSAL HLTH SVCS INC CL B 913903100 214 2,236 SH   SOLE   2,236 0 0
UROPLASTY INC COM NEW 917277204 1,791 668,287 SH   SOLE   668,287 0 0
VERSARTIS INC COM 92529L102 8,855 315,796 SH   SOLE   315,796 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 2,840 30,000 SH Put SOLE   30,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 44,513 470,142 SH   SOLE   470,142 0 0
WALGREEN CO COM 931422109 3,707 50,000 SH Call SOLE   50,000 0 0
WALGREEN CO COM 931422109 20,905 282,000 SH   SOLE   282,000 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 97 1,302 SH   SOLE   1,302 0 0
XENCOR INC COM 98401F105 20,226 1,740,621 SH   SOLE   1,740,621 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 3,065 201,628 SH   SOLE   201,628 0 0
ZIMMER HLDGS INC COM 98956P102 25,186 242,500 SH   SOLE   242,500 0 0
COVIDIEN PLC SHS G2554F113 2,255 25,000 SH   SOLE   25,000 0 0
ICON PLC SHS G4705A100 115 2,440 SH   SOLE   2,440 0 0
PROTHENA CORP PLC SHS G72800108 10,895 483,162 SH   SOLE   483,162 0 0
QUOTIENT LTD SHS G73268107 2,499 300,000 SH   SOLE   300,000 0 0
GALMED PHARMACEUTICALS LTD SHS M47238106 731 75,000 SH   SOLE   75,000 0 0
SYNERON MEDICAL LTD ORD SHS M87245102 1,187 115,000 SH   SOLE   115,000 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 130 924 SH   SOLE   924 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 19,560 139,474 SH   SOLE   139,474 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 22,570 160,935 SH   SOLE   160,935 0 0