The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ANI PHARMACEUTICALS INCCOM00182C1031,41145,000SH SOLE 45,00000
ABBVIE INCCOM00287Y1093,44467,000SH SOLE 67,00000
ABIOMED INCCOM0036541001305,000SH SOLE 5,00000
ACADIA PHARMACEUTICALS INCCOM00422510816,204666,000SH SOLE 666,00000
ACASTI PHARMA INCCL A SHRS00430K1053,2992,869,447SH SOLE 2,869,44700
ACHAOGEN INCCOM00444910492860,000SH SOLE 60,00000
ACELRX PHARMACEUTICALS INCCOM00444T10078,9546,574,060SH SOLE 6,574,06000
AERIE PHARMACEUTICALS INCCOM00771V1084,482211,518SH SOLE 211,51800
AGENUS INCCOM NEW00847G705634200,000SH SOLE 200,00000
ALERE INCCOM01449J1051273,700SH SOLE 3,70000
ALLIQUACOM0196212006,472784,594SH SOLE 784,59400
ALNYLAM PHARMACEUTICALS INCCOM02043Q1073,35750,000SH SOLE 50,00000
AMICUS THERAPEUTICS INCCOM03152W1092,000966,300SH SOLE 966,30000
ANACOR PHARMACEUTICALS INCCOM03242010112,947647,015SH SOLE 647,01500
ANTHERA PHARMACEUTICALS INCCOM NEW03674U2011,603478,456SH SOLE 478,45600
AQUINOX PHARMACEUTICALS INCCOM03842B1011,655130,000SH SOLE 130,00000
ARNO THERAPEUTICSCOM0425642034,5172,034,721SH SOLE 2,034,72100
ARROWHEAD RESH CORPCOM NEW0427972095,210317,300SH SOLE 317,30000
ATHERSYS INCCOM04744L1062,273701,582SH SOLE 701,58200
ATRICURE INCCOM04963C2091,881100,000SH SOLE 100,00000
BIODELIVERY SCIENCES INTL INCOM09060J1061,604190,000SH SOLE 190,00000
BIOTA PHARMACEUTIALS INCCOM0906941002,536415,000SH SOLE 415,00000
BIOLINERX LTDSPONSORED ADR09071M106399179,041SH SOLE 179,04100
BLUEBIRD BIO INCCOM09609G10045520,000SH SOLE 20,00000
CIGNA CORPORATIONCOM1255091091061,269SH SOLE 1,26900
CAPITAL SR LIVING CORPCOM1404751045,263202,500SH SOLE 202,50000
CASTLIGHT HEALTH INCCOM14862Q1001808,500SH SOLE 8,50000
CELGENE CORPCOM15102010428,786206,200SH SOLE 206,20000
CENTENE CORP DELCOM15135B1011622,610SH SOLE 2,61000
CHAMPIONS ONCOLOGYCOM15870P1091,6091,625,299SH SOLE 1,625,29900
CHELSEA THERAPEUTICS INTL LTCOM1634281057,1851,301,639SH SOLE 1,301,63900
CHIMERIX INCCOM16934W1063,199140,000SH SOLE 140,00000
CLOVIS ONCOLOGY INCCOM18946410011,929172,217SH SOLE 172,21700
COMBIMATRIX CORPORATIONW EXP 5-1-201420009T12195,000SH SOLE 5,00000
CYTOKINETICS INCCOM NEW23282W6056,650700,000SHCallSOLE 700,00000
DAVITA HEALTHCARE PARTNERS ICOM23918K1081642,382SH SOLE 2,38200
DERMA SCIENCES INCCOM PAR .012498275026,756532,800SH SOLE 532,80000
DURECT CORPCOM2666051041,206907,064SH SOLE 907,06400
DYAX CORPCOM26746E10323,0132,562,674SH SOLE 2,562,67400
ENDOCYTE INCCOM29269A10210,357435,000SH SOLE 435,00000
ENZO BIOCHEM INCCOM2941001021,581380,000SH SOLE 380,00000
EPIZYME INCCOM29428V1041,19852,602SH SOLE 52,60200
EXACT SCIENCES CORPCOM30063P10525,8621,825,150SH SOLE 1,825,15000
EXACT SCIENCES CORPCOM30063P10512,753900,000SHPutSOLE 900,00000
EXELIXIS INCCOM30161Q1041,416400,000SHCallSOLE 400,00000
FIVE PRIME THERAPEUTICS INCCOM33830X1042,949150,000SH SOLE 150,00000
FLAMEL TECHNOLOGIES SASPONSORED ADR33848810910,720800,000SH SOLE 800,00000
FLUIDIGM CORP DELCOM34385P1081353,070SH SOLE 3,07000
GENVEC INCCOM NEW37246C3072,173820,000SH SOLE 820,00000
GILEAD SCIENCES INCCOM3755581033,54350,000SH SOLE 50,00000
GLOBUS MED INCCL A SHRS3795772084,520170,000SH SOLE 170,00000
HCA HOLDINGS INCCOM40412C1017,875150,000SH SOLE 150,00000
HEALTH NET INCCOM42222G1081795,275SH SOLE 5,27500
HERON THERAPEUTICS INCCOM42774610224,5151,762,426SH SOLE 1,762,42600
HORIZON PHARMA INCCOM44047T1091389,120SH SOLE 9,12000
HUMANA INCCOM4448591021411,250SH SOLE 1,25000
ICAD INCCOM NEW44934S2061,603175,000SH SOLE 175,00000
IDENIX PHARMACEUTICALS INCCOM45166R2041,809300,000SHCallSOLE 300,00000
ILLUMINA INCCOM4523271093722,500SH SOLE 2,50000
IMPAX LABORATORIES INCCOM45256B1011585,962SH SOLE 5,96200
INCYTE CORPCOM45337C1029,837183,800SH SOLE 183,80000
INSMED INCCOM PAR .014576693076,474340,000SH SOLE 340,00000
INSYS THERAPEUTICS INC NEWCOM NEW45824V2092556,153SH SOLE 6,15300
INTERMUNE INCCOM45884X1033,347100,000SHCallSOLE 100,00000
INTERMUNE INCCOM45884X1038,702260,000SH SOLE 260,00000
KERYX BIOPHARMACEUTICALS INCCOM4925151014,686275,000SH SOLE 275,00000
LANNET INCCOM5160121012416,744SH SOLE 6,74400
LION BIOTECHNOLOGIESCOM53619R10228,3203,000,000SH SOLE 3,000,00000
MGC DIAGNOSTICS CORPCOM5527681032,310206,957SH SOLE 206,95700
MACROGENICS INCCOM55609910912,494448,945SH SOLE 448,94500
MEDGENICS INCCOM NEW58436Q20342861,263SH SOLE 61,26300
MEDIDATA SOLUTIONS INCCOM58471A1051522,802SH SOLE 2,80200
MEDIVATION INCCOM58501N1012,05331,900SH SOLE 31,90000
MYLAN INCCOM62853010711,353232,500SH SOLE 232,50000
NEPTUNE TECHNOLOGIES BIORESOCOM64077P10816,5506,700,444SH SOLE 6,700,44400
NEUROCRINE BIOSCIENCES INCCOM64125C10974,3724,619,367SH SOLE 4,619,36700
NEWLINK GENETICS CORPCOM6515111071,42050,000SHCallSOLE 50,00000
OMNICARE INCCOM6819041081031,732SH SOLE 1,73200
ONCOTHYREON INCCOM6823241081,624543,000SH SOLE 543,00000
OPHTHOTECH CORPCOM6837451038,935250,000SH SOLE 250,00000
OXIGENE INCCOM PAR .0016918284041,865500,000SH SOLE 500,00000
PTC THERAPEUTICSCOM69366J20017,558671,736SH SOLE 671,73600
PACIRA PHARMACEUTICALSCOM6951271001392,000SH SOLE 2,00000
PAIN THERAPEUTICSCOM69562K10019435,506SH SOLE 35,50600
PUMA BIOTECHNOLOGYCOM74587V10776735SH SOLE 73500
QUESTCOR PHARMACEUTICALSCOM74835Y1011,85728,600SH SOLE 28,60000
RECEPTOS INCCOM7562071061,46835,000SH SOLE 35,00000
RELYPSA INCCOM7595311065,402181,200SH SOLE 181,20000
REPLIGEN CORPCOM75991610957945,000SHPutSOLE 45,00000
RETROPHIN INCCOM76129910622,1381,044,292SH SOLE 1,044,29200
RIGEL PHARMACEUTICALS INCCOM NEW76655960319450,000SH SOLE 50,00000
RITE AID CORPCOM7677541049414,924SH SOLE 14,92400
SANGAMO BIOSCIENCES INCCOM80067710614,464800,000SH SOLE 800,00000
Sarepta Therapeutics IncCOM8036071008,413350,000SHCallSOLE 350,00000
SAREPTA THERAPEUTICS INCCOM80360710069,1822,878,979SH SOLE 2,878,97900
SHIRE PLCSPONSORED ADR82481R1064,45630,000SH SOLE 30,00000
SPECTRANETICS CORPCOM84760C10710,080332,554SH SOLE 332,55400
STEMCELLS INCCOM NEW85857R204364271,600SH SOLE 271,60000
STEMLINE THERAPEUTICS INCCOM85858C107138SH SOLE 3800
SURGICAL CARE AFFILIATES INCCOM86881L1062307,472SH SOLE 7,47200
TANDEM DIABETES CARE INCCOM8753721042,339105,900SH SOLE 105,90000
TEKMIRA PHARMACEUTICALS CORPCOM NEW87911B2092,149100,000SHPutSOLE 100,00000
TESARO INCCOM88156910736,2621,230,070SH SOLE 1,230,07000
THERAPEUTICSMD INCCOM88338N107447,000SH SOLE 7,00000
TRANSGENOMIC INCCOM89365K305842183,957SH SOLE 183,95700
TREVENA INCCOM89532E1096,052770,000SH SOLE 770,00000
UROPLASTY INCCOM NEW9172772041,880517,791SH SOLE 517,79100
VERASTEM INCCOM92337C1042,391220,000SH SOLE 220,00000
VERTEX PHARMACEUTICALS INCCOM92532F10021,216300,000SHPutSOLE 300,00000
VERTEX PHARMACEUTICALS INCCOM92532F10041,140581,728SH SOLE 581,72800
VIVUS INCCOM928551100594100,000SHPutSOLE 100,00000
VOCERA COMMUNICATIONS INCCOM92857F10716310,000SH SOLE 10,00000
WALGREEN COCOM93142210920,101304,419SH SOLE 304,41900
WRIGHT MED GROUP INCCOM98235T10731110,000SH SOLE 10,00000
XENCOR INCCOM98401F10517,4621,488,672SH SOLE 1,488,67200
XENOPORT INCCOM98411C10025850,000SH SOLE 50,00000
ZELTIQ AESTHETICS INCCOM98933Q10811,503586,013SH SOLE 586,01300
ACTAVIS PLCSHSG0083B108195945SH SOLE 94500
COVIDIEN PLCSHSG2554F11319,365262,900SH SOLE 262,90000
ENDO INTL PLCSHSG30401106781,138SH SOLE 1,13800
PROTHENA CORP PLCSHSG7280010813,409350,000SH SOLE 350,00000
COMPUGEN LTDORDM257221051,787170,000SH SOLE 170,00000
ENZYMOTEC LTDSHSM4059L1014,717214,219SH SOLE 214,21900
GALMED PHARMACEUTICALS LTDSHSM4723810686075,000SH SOLE 75,00000
SYNERON MEDICAL LTDORDM872451021,587127,500SH SOLE 127,50000
TARO PHARMACEUTICAL INDS LTDSHSM8737E10810,76897,011SH SOLE 97,01100
VERSARTIS INCCOM92529L10215,063501,266SH SOLE 501,26600