X0306 4 2013-06-15 1 0001338042 Aegerion Pharmaceuticals, Inc. AEGR 0001224962 PERCEPTIVE ADVISORS LLC 499 PARK AVENUE 25TH FLOOR NEW YORK NY 10022 0 0 1 0 0001164426 EDELMAN JOSEPH C/O PERCEPTIVE ADVISORS LLC 499 PARK AVENUE, 25TH FLOOR NEW YORK NY 10022 0 0 1 0 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD C/O PERCEPTIVE ADVISORS LLC 499 PARK AVENUE, 25TH FLOOR NEW YORK NY 10022 0 0 1 0 Common Stock 2013-06-15 4 X 0 100000 25 A 3473426 I See Footnotes Common Stock 2013-06-15 4 X 0 100000 25 A 3573426 I See Footnotes Common Stock 2013-09-05 4 S 0 700000 89.2 D 2873426 I See Footnotes Common Stock 2013-09-05 4 S 0 50000 89.2 D 2823426 I See Footnotes Call option (right to buy) 25 2013-06-15 4 X 0 1000 0 D 2013-06-15 2013-06-15 Common Stock 100000 1000 I See Footnotes Call option (right to buy) 25 2013-06-15 4 X 0 1000 0 D 2013-06-15 2013-06-15 Common Stock 100000 0 I See Footnotes This Form 4 is being filed by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"), Perceptive Advisors LLC (the "Advisor") and Joseph Edelman. The Advisor serves as investment manager to the Master Fund and to a managed account (the "Managed Account") for BioEdelman LLC, an entity directly owned by Mr. Edelman. Mr. Edelman is the managing member of the Advisor. This transaction reflects the exercise of an in-the-money option by the Advisor on behalf of the Master Fund. This transaction reflects the exercise of an in-the-money option by the Advisor on behalf of the Managed Account. This transaction reflects the sale of securities by the Advisor on behalf of the Master Fund. This transaction reflects the sale of securities by the Advisor on behalf of the Managed Account. This amount reflects the total amount of securities held by the Master Fund and the Managed Account immediately following the transaction requiring the filing of this statement. In accordance with Instruction 5(b)(iv) of Form 4, the entire amount of the Issuer's securities held by the Master Fund and the Managed Account is reported herein. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. /s/ Joseph Edelman, managing member of Perceptive Advisors LLC 2013-09-09