X0306 4 2013-03-15 1 0000897075 REPROS THERAPEUTICS INC. RPRX 0001224962 PERCEPTIVE ADVISORS LLC 499 PARK AVENUE 25TH FLOOR NEW YORK NY 10022 0 0 1 0 0001164426 EDELMAN JOSEPH PERCEPTIVE ADVISORS LLC 499 PARK AVENUE, 25TH FLOOR NEW YORK NY 10022 0 0 1 0 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD C/O PERCEPTIVE ADVISORS LLC 499 PARK AVENUE, 25TH FLOOR NEW YORK NY 10022 0 0 1 0 Common Stock 2013-03-15 4 X 0 100000 10 D 2762560 I See Footnotes Common Stock 2013-03-15 4 X 0 150000 15 D 2612560 I See Footnotes Common Stock 2013-03-15 4 X 0 400000 12.50 D 2212560 I See Footnotes Common Stock 2013-03-15 4 X 0 200000 12.50 D 2012560 I See Footnotes Common Stock 2013-03-15 4 X 0 100000 12.50 D 1912560 I See Footnotes Common Stock 2013-03-15 4 X 0 400000 12.50 D 1512560 I See Footnotes Common Stock 2013-03-15 4 X 0 150000 12.50 D 1362560 I See Footnotes Common Stock 2013-03-15 4 X 0 100000 12.50 D 1262560 I See Footnotes Common Stock 2013-03-15 4 X 0 100000 10.00 D 1162560 I See Footnotes Common Stock 2013-03-15 4 X 0 50000 10.00 D 1112560 I See Footnotes Common Stock 2013-03-15 4 X 0 50000 12.50 D 1062560 I See Footnotes Common Stock 2013-03-15 4 X 0 100000 12.50 D 962560 I See Footnotes Common Stock 2013-03-15 4 X 0 50000 12.50 D 912560 I See Footnotes Common Stock 2013-03-15 4 X 0 50000 12.50 D 862560 I See Footnotes Common Stock 2013-03-15 4 X 0 50000 10.00 D 812560 I See Footnotes Put option (right to sell) 10 2013-03-15 4 X 0 1000 0 A 2013-01-28 2013-03-16 Common Stock 100000 63500 I See Footnotes Put option (right to sell) 15 2013-03-15 4 X 0 1500 0 A 2013-01-28 2013-03-16 Common Stock 150000 62000 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 4000 0 A 2013-01-29 2013-03-16 Common Stock 400000 58000 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 2000 0 A 2013-01-30 2013-03-16 Common Stock 200000 56000 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 1000 0 A 2013-01-31 2013-03-16 Common Stock 100000 55000 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 4000 0 A 2013-02-06 2013-03-16 Common Stock 400000 51000 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 1500 0 A 2013-02-07 2013-03-16 Common Stock 150000 49500 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 1000 0 A 2013-02-11 2013-03-16 Common Stock 100000 48500 I See Footnotes Put option (right to sell) 10.00 2013-03-15 4 X 0 1000 0 A 2013-02-19 2013-03-16 Common Stock 100000 47500 I See Footnotes Put option (right to sell) 10.00 2013-03-15 4 X 0 500 0 A 2013-02-20 2013-03-16 Common Stock 50000 47000 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 500 0 A 2013-02-25 2013-03-16 Common Stock 50000 46500 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 1000 0 A 2013-03-04 2013-03-16 Common Stock 100000 45500 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 500 0 A 2013-03-05 2013-03-16 Common Stock 50000 45000 I See Footnotes Put option (right to sell) 12.50 2013-03-15 4 X 0 500 0 A 2013-03-16 Common Stock 50000 44500 I See Footnotes Put option (right to sell) 10.00 2013-03-15 4 X 0 500 0 A 2013-03-16 Common Stock 50000 44000 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 4000 0 A 2013-01-29 2013-03-16 Common Stock 400000 40000 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 2000 0 A 2013-01-30 2013-03-16 Common Stock 200000 38000 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 1000 0 A 2013-01-31 2013-03-16 Common Stock 100000 37000 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 1000 0 A 2013-02-01 2013-03-16 Common Stock 100000 36000 I See Footnotes Call option (right to sell) 10.00 2013-03-16 4 E 0 500 0 A 2013-02-04 2013-03-16 Common Stock 50000 35500 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 6000 0 A 2013-02-05 2013-03-16 Common Stock 600000 29500 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 2000 0 A 2013-02-06 2013-03-16 Common Stock 200000 27500 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 1500 0 A 2013-02-07 2013-03-16 Common Stock 150000 26000 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 1000 0 A 2013-02-11 2013-03-16 Common Stock 100000 25000 I See Footnotes Call option (right to sell) 10.00 2013-03-16 4 E 0 1000 0 A 2013-02-19 2013-03-16 Common Stock 100000 24000 I See Footnotes Call option (right to sell) 10.00 2013-03-16 4 E 0 500 0 A 2013-02-20 2013-03-16 Common Stock 50000 23500 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 500 0 A 2013-02-25 2013-03-16 Common Stock 50000 23000 I See Footnotes Call option (right to sell) 12.50 2013-03-16 4 E 0 500 0 A 2013-03-16 Common Stock 50000 22500 I See Footnotes Call option (right to sell) 10.00 2013-03-16 4 E 0 500 0 A 2013-03-16 Common Stock 50000 22000 I See Footnotes This Form 4 is being filed by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"), Perceptive Advisors LLC (the "Advisor") and Joseph Edelman. The Advisor serves as investment manager to the Master Fund. Mr. Edelman is the managing member of the Advisor. This amount reflects the total amount of derivative securities held by the Master Fund immediately following the transactions requiring the filing of this statement. In accordance with Instruction 5(b)(iv) of Form 4, the entire amount of the Issuer's derivative securities held by the Master Fund is reported herein. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. The put options reflected in this Form 4 are in-the money options that were exercisable when purchased. The call options reflected in this Form 4 are out-of-the money options that were exercisable when written. /s/ Joseph Edelman, managing member of Perceptive Advisors LLC 2013-03-19