X0306 4 2013-03-04 0 0000897075 REPROS THERAPEUTICS INC. RPRX 0001224962 PERCEPTIVE ADVISORS LLC 499 PARK AVENUE 25TH FLOOR NEW YORK NY 10022 0 0 1 0 0001164426 EDELMAN JOSEPH PERCEPTIVE ADVISORS LLC 499 PARK AVENUE, 25TH FLOOR NEW YORK NY 10022 0 0 1 0 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD C/O PERCEPTIVE ADVISORS LLC 499 PARK AVENUE, 25TH FLOOR NEW YORK NY 10022 0 0 1 0 Put option (right to sell) 12.5 2013-03-04 4 P 0 1000 1.945 A 2013-03-16 Common Stock 100000 64000 I See Footnotes Put option (right to sell) 12.5 2013-03-05 4 P 0 500 2.76 A 2013-03-16 Common Stock 50000 64500 I See Footnotes This Form 4 is being filed by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"), Perceptive Advisors LLC (the "Advisor") and Joseph Edelman. The Advisor serves as investment manager to the Master Fund. Mr. Edelman is the managing member of the Advisor. This amount reflects the total amount of derivative securities held by the Master Fund immediately following the transactions requiring the filing of this statement. In accordance with Instruction 5(b)(iv) of Form 4, the entire amount of the Issuer's derivative securities held by the Master Fund is reported herein. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. The options reflected in this Form 4 are out-of-the money options. /s/ Joseph Edelman, managing member of Perceptive Advisors LLC 2013-03-06