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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   36,882,860 238,000 SH   SOLE   238,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   3,162,310 101,000 SH   SOLE   101,000 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   14,798,661 3,007,858 SH   SOLE   3,007,858 0 0
ADMA BIOLOGICS INC COM 000899104   29,078,828 6,433,369 SH   SOLE   6,433,369 0 0
AKERO THERAPEUTICS INC COM 00973Y108   22,597,546 967,775 SH   SOLE   967,775 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   30,163,487 8,593,586 SH   SOLE   8,593,586 0 0
AMBRX BIOPHARMA INC COM 641871108   1,122,268 78,811 SH   SOLE   78,811 0 0
AMICUS THERAPEUTICS INC COM 03152W109   398,135,301 28,057,456 SH   SOLE   28,057,456 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   27,513,520 1,869,125 SH   SOLE   1,869,125 0 0
APOGEE THERAPEUTICS INC COM 03770N101   51,071,553 1,827,901 SH   SOLE   1,827,901 0 0
APPLIED THERAPEUTICS INC COM 03828A101   500,000 500,000 SH Call SOLE   500,000 0 0
APPLIED THERAPEUTICS INC COM 03828A101   13,668,834 4,080,249 SH   SOLE   4,080,249 0 0
ARCELLX INC COMMON STOCK 03940C100   252,236,900 4,544,809 SH   SOLE   4,544,809 0 0
ARTIVION INC COM 228903100   16,652,574 931,352 SH   SOLE   931,352 0 0
ARVINAS INC COM 04335A105   14,574,015 354,082 SH   SOLE   354,082 0 0
ASCENDIS PHARMAA/S SPONSORED ADR 04351P101   16,647,567 132,176 SH   SOLE   132,176 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   30,751,257 4,004,070 SH   SOLE   4,004,070 0 0
ATHIRA PHARMA INC COM 04746L104   13,129,202 5,402,964 SH   SOLE   5,402,964 0 0
AUTOLUS THERAPEUTICS PLC SPON ADS 05280R100   11,792,715 1,831,167 SH   SOLE   1,831,167 0 0
AXOGEN INC COM 05463X106   5,521,235 808,380 SH   SOLE   808,380 0 0
AXSOME THERAPEUTICS INC COM 05464T104   82,615,932 1,038,019 SH   SOLE   1,038,019 0 0
BIOATLA INC COM 09077B104   179,580 73,000 SH   SOLE   73,000 0 0
BIOHAVEN LTD COM G1110E107   73,832,012 1,725,047 SH   SOLE   1,725,047 0 0
BRIDGEBIO PHARMA INC COM 10806X102   70,604,425 1,748,933 SH   SOLE   1,748,933 0 0
CABALETTA BIO INC COM 12674W109   45,469,417 2,003,058 SH   SOLE   2,003,058 0 0
CAREMAX INC COM CL A 14171W103   1,832,283 3,679,284 SH   SOLE   3,679,284 0 0
CAREMAX INC *W EXP 06/08/202 14171W111   450 60,000 SH   SOLE   60,000 0 0
CARGO THERAPEUTICS INC COM 14179K101   79,557,290 3,436,600 SH   SOLE   3,436,600 0 0
CELCUITY INC COM 15102K100   21,582,541 1,481,300 SH   SOLE   1,481,300 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   464,924,183 10,965,193 SH   SOLE   10,965,193 0 0
COGENT BIOSCIENCES INC COM 19240Q201   6,602,993 1,122,958 SH   SOLE   1,122,958 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   44,671,117 1,255,512 SH   SOLE   1,255,512 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   95,056,328 4,024,400 SH   SOLE   4,024,400 0 0
CYTOKINETICS INC COM NEW 23282W605   2,531,166 30,317 SH   SOLE   30,317 0 0
DISC MEDICINE INC COM 254604101   59,091,079 1,023,045 SH   SOLE   1,023,045 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   6,077,772 555,555 SH   SOLE   555,555 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106   3,203,839 623,315 SH   SOLE   623,315 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   2,130,721 82,299 SH   SOLE   82,299 0 0
EVOLUS INC COM 30052C107   41,734,855 3,963,424 SH   SOLE   3,963,424 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   37,500 750,000 SH Put SOLE   750,000 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   13,626,719 589,646 SH   SOLE   589,646 0 0
FORTE BIOSCIENCES INC COM 34962G109   2,683,145 3,265,359 SH   SOLE   3,265,359 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   26,440,905 2,751,395 SH   SOLE   2,751,395 0 0
IMMATICS N.V SHS N44445109   36,765,495 3,491,500 SH   SOLE   3,491,500 0 0
IMMUNOVANT INC COM 45258J102   98,082,095 2,328,082 SH   SOLE   2,328,082 0 0
INHIBRX INC COM 45720L107   161,731,952 4,256,104 SH   SOLE   4,256,104 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   7,734,960 108,000 SH   SOLE   108,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   18,554,800 55,000 SH   SOLE   55,000 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   97,392,643 11,979,415 SH   SOLE   11,979,415 0 0
KRONOS BIO INC COM 50107A104   2,190,931 1,752,745 SH   SOLE   1,752,745 0 0
LANDOS BIOPHARMA INC COM NEW 515069201   5,442,387 1,486,991 SH   SOLE   1,486,991 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200   186,404 44,971 SH   SOLE   44,971 0 0
LIANBIO SPONSORED ADS 53000N108   257,256,275 57,558,451 SH   SOLE   57,558,451 0 0
LYRA THERAPEUTICS INC COM 55234L105   66,849,624 12,757,562 SH   SOLE   12,757,562 0 0
MACROGENICS INC COM 556099109   5,886,786 611,932 SH   SOLE   611,932 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   34,973,318 151,151 SH   SOLE   151,151 0 0
MEDTRONIC PLC SHS G5960L103   80,456,592 976,652 SH   SOLE   976,652 0 0
MEIRAGTX HLDGS PLC COM G59665102   79,544,343 11,331,103 SH   SOLE   11,331,103 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   15,791,488 534,942 SH   SOLE   534,942 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   4,976,015 82,398 SH   SOLE   82,398 0 0
MORPHIC HLDGS INC COM 61775R105   1,645,582 56,980 SH   SOLE   56,980 0 0
NANOBIOTIX SPONSORED ADS 63009J107   4,040,880 555,066 SH   SOLE   555,066 0 0
NATERA INC COM 632307104   53,258,094 850,225 SH   SOLE   850,225 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   37,656,690 12,594,211 SH   SOLE   12,594,211 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   35,679,817 270,794 SH   SOLE   270,794 0 0
NOVAVAX INC COM NEW 670002401   4,755,000 1,400,000 SH Put SOLE   1,400,000 0 0
NUVALENT INC COM 670703107   214,734,958 2,917,991 SH   SOLE   2,917,991 0 0
OLEMA PHARMACEUTICALS INC COM 68062P106   7,573,829 539,831 SH   SOLE   539,831 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   22,204,972 2,432,089 SH   SOLE   2,432,089 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   8,788,152 383,260 SH   SOLE   383,260 0 0
RAPT THERAPEUTICS INC COM 75382E109   53,177,758 2,139,950 SH   SOLE   2,139,950 0 0
RAYZEBIO INC COM 75525N107   46,257,961 744,056 SH   SOLE   744,056 0 0
REGENXBIO INC COM 75901B107   6,146,224 342,408 SH   SOLE   342,408 0 0
REVOLUTION MEDICINES INC COM 76155X100   23,485,536 818,882 SH   SOLE   818,882 0 0
REVOLUTION MEDICINES INC *W EXP 12/17/202 76155X118   82,500 250,000 SH   SOLE   250,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   99,024,437 2,154,110 SH   SOLE   2,154,110 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   51,170,718 1,707,398 SH   SOLE   1,707,398 0 0
SAREPTA THERAPEUTICS INC COM 803607100   43,574,113 451,873 SH   SOLE   451,873 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   978,583 2,126,893 SH   SOLE   2,126,893 0 0
SOLENO THERAPEUTICS INC COM 834203309   123,750,315 3,074,542 SH   SOLE   3,074,542 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   21,465,028 3,495,933 SH   SOLE   3,495,933 0 0
SPDR SER TR S&P BIOTECH 78464A870   1,281,500 1,900,000 SH Put SOLE   1,900,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   71,439,479 1,957,246 SH   SOLE   1,957,246 0 0
SPYRE THERAPEUTICS INC COM NEW 00773J202   56,095,732 2,606,679 SH   SOLE   2,606,679 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   3,333 166,666 SH   SOLE   166,666 0 0
TACTILE SYS TECHNOLOGY INC COM 87357P100   10,112,374 707,159 SH   SOLE   707,159 0 0
TANGO THERAPEUTICS INC COM 87583X109   11,007,513 1,111,870 SH   SOLE   1,111,870 0 0
TARSUS PHARMACEUTICALS COM 87650L103   26,252,424 1,296,416 SH   SOLE   1,296,416 0 0
TERNS PHARMACEUTICALS INC COM 880881107   6,976,750 1,075,000 SH   SOLE   1,075,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   3,596,000 400,000 SH   SOLE   400,000 0 0
TREACE MED CONCEPTS INC COM 89455T109   15,942,664 1,250,405 SH   SOLE   1,250,405 0 0
TYRA BIOSCIENCES INC COM 90240B106   4,986,000 360,000 SH   SOLE   360,000 0 0
VAXCYTE INC COM 92243G108   68,356,921 1,088,486 SH   SOLE   1,088,486 0 0
VBI VACCINES INC CDA COM NEW 91822J202   814,999 1,381,355 SH   SOLE   1,381,355 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   76,860,334 3,866,214 SH   SOLE   3,866,214 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108   51,966,012 7,099,182 SH   SOLE   7,099,182 0 0
VERU INC COM 92536C103   4,020,983 5,584,699 SH   SOLE   5,584,699 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   37,684,017 1,730,212 SH   SOLE   1,730,212 0 0
X4 PHARMACEUTICALS INC COM 98420X103   2,972,863 3,545,454 SH   SOLE   3,545,454 0 0
XENON PHARMACEUTICALS INC COM 98420N105   50,700,453 1,100,748 SH   SOLE   1,100,748 0 0
ZYMEWORKS INC COM 98985Y108   11,167,245 1,074,807 SH   SOLE   1,074,807 0 0