The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103   1,620,000 400,000 SH Call SOLE   400,000 0 0
ACELYRIN INC COM 00445A100   2,034,000 200,000 SH   SOLE   200,000 0 0
ACLARIS THERAPEUTICS INC COM 00461U105   1,450,000 500,000 SH Put SOLE   500,000 0 0
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   28,755,122 3,007,858 SH   SOLE   3,007,858 0 0
ADMA BIOLOGICS INC COM 000899104   25,003,862 6,984,319 SH   SOLE   6,984,319 0 0
AEGLEA BIOTHERAPEUTICS INC COM NEW 00773J202   993,671 81,116 SH   SOLE   81,116 0 0
AKERO THERAPEUTICS INC COM 00973Y108   81,910,517 1,619,425 SH   SOLE   1,619,425 0 0
AKERO THERAPEUTICS INC COM 00973Y108   5,460,000 800,000 SH Call SOLE   800,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106   75,818,568 11,350,085 SH   SOLE   11,350,085 0 0
AMICUS THERAPEUTICS INC COM 03152W109   336,745,870 27,692,917 SH   SOLE   27,692,917 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101   49,233,265 2,688,873 SH   SOLE   2,688,873 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   72,500 100,000 SH Put SOLE   100,000 0 0
APOGEE THERAPEUTICS INC COM 03770N101   38,934,291 1,827,901 SH   SOLE   1,827,901 0 0
ARCELLX INC COMMON STOCK 03940C100   142,299,291 3,965,978 SH   SOLE   3,965,978 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   2,622,500 300,000 SH Put SOLE   300,000 0 0
ARGENX SE SPONSORED ADR 04016X101   74,039,478 150,600 SH   SOLE   150,600 0 0
ARTIVION INC COM 228903100   14,119,296 931,352 SH   SOLE   931,352 0 0
ASTRIA THERAPEUTICS INC COM 04635X102   16,333,387 2,189,462 SH   SOLE   2,189,462 0 0
ATHIRA PHARMA INC COM 04746L104   9,690,501 4,797,278 SH   SOLE   4,797,278 0 0
AXOGEN INC COM 05463X106   4,379,490 875,898 SH   SOLE   875,898 0 0
AXSOME THERAPEUTICS INC COM 05464T104   33,662,449 481,649 SH   SOLE   481,649 0 0
BIOHAVEN LTD COM G1110E107   19,554,838 751,820 SH   SOLE   751,820 0 0
BIOMEA FUSION COM 09077A106   9,858,228 716,441 SH   SOLE   716,441 0 0
BRIDGEBIO PHARMA COM 10806X102   46,119,363 1,748,933 SH   SOLE   1,748,933 0 0
CABALETTA BIO INC COM 12674W109   17,236,513 1,132,491 SH   SOLE   1,132,491 0 0
CAREMAX INC COM CL A 14171W103   8,105,940 3,823,557 SH   SOLE   3,823,557 0 0
CAREMAX INC *W EXP 06/08/202 14171W111   11,250 60,000 SH   SOLE   60,000 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   220,229,445 10,088,385 SH   SOLE   10,088,385 0 0
COGENT BIOSCIENCES INC COM 19240Q201   22,517,333 2,309,470 SH   SOLE   2,309,470 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   37,583,389 1,263,732 SH   SOLE   1,263,732 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   60,283,978 4,043,191 SH   SOLE   4,043,191 0 0
DISC MEDICINE INC COM 254604101   42,077,214 895,641 SH   SOLE   895,641 0 0
ENVVENO MEDICAL CORPORATION COM 29415J106   4,212,905 781,615 SH   SOLE   781,615 0 0
EQRX INC *W EXP 12/17/202 26886C115   10,000 250,000 SH   SOLE   250,000 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108   13,625,905 277,683 SH   SOLE   277,683 0 0
EVOLUS INC COM 30052C107   13,580,221 1,485,801 SH   SOLE   1,485,801 0 0
EYEPOINT PHARMACEUTICALS INC COM NEW 30233G209   2,512,500 750,000 SH Put SOLE   750,000 0 0
FORTE BIOSCIENCES INC COM 34962G109   2,161,667 3,265,359 SH   SOLE   3,265,359 0 0
FUSION PHARMACEUTICALS INC COM 36118A100   7,153,627 2,751,395 SH   SOLE   2,751,395 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   32,648,948 996,306 SH   SOLE   996,306 0 0
IMMATICS N.V SHS N44445109   40,431,570 3,491,500 SH   SOLE   3,491,500 0 0
IMMUNOVANT INC COM 45258J102   146,445,987 3,814,691 SH   SOLE   3,814,691 0 0
INHIBRX INC COM 45720L107   78,099,508 4,256,104 SH   SOLE   4,256,104 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100   54,431,367 11,962,938 SH   SOLE   11,962,938 0 0
KRONOS BIO INC COM 50107A104   2,278,568 1,752,745 SH   SOLE   1,752,745 0 0
LANDOS BIOPHARMA INC COM NEW 515069201   5,769,525 1,486,991 SH   SOLE   1,486,991 0 0
LEAP THERAPEUTICS INC COM NEW 52187K200   62,059 44,971 SH   SOLE   44,971 0 0
LIANBIO SPONSORED ADS 53000N108   85,762,091 57,558,451 SH   SOLE   57,558,451 0 0
LYRA THERAPEUTICS INC COM 55234L105   49,882,067 12,757,562 SH   SOLE   12,757,562 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   18,201,987 124,637 SH   SOLE   124,637 0 0
MEDTRONIC PLC SHS G5960L103   45,997,320 587,000 SH   SOLE   587,000 0 0
MEIRAGTX HLDGS PLC COM G59665102   55,635,715 11,331,103 SH   SOLE   11,331,103 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   21,236,527 672,042 SH   SOLE   672,042 0 0
MOTUS GI HLDGS INC COM NEW 62014P405   40,512 90,027 SH   SOLE   90,027 0 0
NANOBIOTIX SPONSORED ADS 63009J107   4,856,828 555,066 SH   SOLE   555,066 0 0
NATERA INC COM 632307104   9,654,377 218,178 SH   SOLE   218,178 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108   28,791,237 9,111,151 SH   SOLE   9,111,151 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   17,914,725 159,242 SH   SOLE   159,242 0 0
NOVAVAX INC COM NEW 670002401   3,772,520 1,300,000 SH Put SOLE   1,300,000 0 0
NUVALENT INC COM 670703107   113,244,842 2,463,451 SH   SOLE   2,463,451 0 0
ORCHESTRA BIOMED HLDGS INC COM 68572M106   21,207,816 2,432,089 SH   SOLE   2,432,089 0 0
OUTSET MED INC COM 690145107   7,202,310 661,977 SH   SOLE   661,977 0 0
POINT BIOPHARMA GLOBAL INC COM 730541109   2,630,000 800,000 SH Put SOLE   800,000 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102   17,585,274 1,054,273 SH   SOLE   1,054,273 0 0
PROTHENA CORP PLC SHS G72800108   7,990,924 165,615 SH   SOLE   165,615 0 0
RAPT THERAPEUTICS INC COM 75382E109   31,921,336 1,920,658 SH   SOLE   1,920,658 0 0
RAYZEBIO INC COM 75525N107   17,245,071 776,805 SH   SOLE   776,805 0 0
RELAY THERAPEUTICS INC COM 75943R102   16,341,445 1,943,097 SH   SOLE   1,943,097 0 0
REVOLUTION MEDICINES INC COM 76155X100   36,587,286 1,321,795 SH   SOLE   1,321,795 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   8,730,482 380,828 SH   SOLE   380,828 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   31,092,899 1,517,467 SH   SOLE   1,517,467 0 0
ROIVANT SCIENCES LTD SHS G76279101   44,611,246 3,819,456 SH   SOLE   3,819,456 0 0
SAREPTA THERAPEUTICS INC COM 803607100   22,149,318 182,720 SH   SOLE   182,720 0 0
SAREPTA THERAPEUTICS INC COM 803607100   3,130,000 100,000 SH Call SOLE   100,000 0 0
SINGULAR GENOMICS SYSTEMS IN COM 82933R100   900,385 2,363,214 SH   SOLE   2,363,214 0 0
SOLENO THERAPEUTICS INC COM 834203309   90,729,734 3,074,542 SH   SOLE   3,074,542 0 0
SOMALOGIC INC CLASS A COM 83444K105   3,585,000 1,500,000 SH   SOLE   1,500,000 0 0
SOLID BIOSCIENCES INC COM NEW 83422E204   8,809,751 3,495,933 SH   SOLE   3,495,933 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107   35,152,017 1,520,416 SH   SOLE   1,520,416 0 0
SURROZEN INC *W EXP 08/01/203 86889P117   6,667 166,666 SH   SOLE   166,666 0 0
TACTILE SYS TECHNOLOGY INC COM 87357P100   9,935,584 707,159 SH   SOLE   707,159 0 0
TANGO THERAPEUTICS INC COM 87583X109   27,237,580 2,418,968 SH   SOLE   2,418,968 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103   23,037,312 1,296,416 SH   SOLE   1,296,416 0 0
TERNS PHARMACEUTICALS INC COM 880881107   5,407,250 1,075,000 SH   SOLE   1,075,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107   3,576,000 400,000 SH   SOLE   400,000 0 0
TREACE MED CONCEPTS INC COM 89455T109   24,044,527 1,834,060 SH   SOLE   1,834,060 0 0
TYRA BIOSCIENCES INC COM 90240B106   4,957,200 360,000 SH   SOLE   360,000 0 0
VAXCYTE INC COM 92243G108   68,453,446 1,342,751 SH   SOLE   1,342,751 0 0
VBI VACCINES INC CDA COM NEW 91822J202   925,507 1,381,355 SH   SOLE   1,381,355 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106   65,317,311 4,007,197 SH   SOLE   4,007,197 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108   19,576,448 5,038,983 SH   SOLE   5,038,983 0 0
VERU INC COM 92536C103   783,622 1,089,878 SH   SOLE   1,089,878 0 0
VIKING THERAPEUTICS INC COM 92686J106   240,000 300,000 SH Call SOLE   300,000 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   15,511,885 1,011,205 SH   SOLE   1,011,205 0 0
X4 PHARMACEUTICALS INC COM 98420X103   3,864,545 3,545,454 SH   SOLE   3,545,454 0 0
XENON PHARMACEUTICALS INC COM 98420N105   21,093,800 617,500 SH   SOLE   617,500 0 0
ZYMEWORKS INC COM 98985Y108   9,168,420 1,446,123 SH   SOLE   1,446,123 0 0