The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
1LIFE HEALTHCARE INCCOM68269G10722,691519,844SH SOLE 519,84400
4D MOLECULAR THERAPEUTICS INCOM35104E10024,881600,256SH SOLE 600,25600
908 DEVICES INCCOM65443P1024,41477,500SH SOLE 77,50000
ABCELLERA BIOLOGICS INCCOM00288U10680520,000SH SOLE 20,00000
ACCOLADE INCCOM00437E10227,256626,591SH SOLE 626,59100
ADAPTIMMUNE THERAPEUTICS PLCSPONDS ADR00653A1072,156400,000SH SOLE 400,00000
ADAPTIVE BIOTECHNOLOGIES CORCOM00650F10953,504904,854SH SOLE 904,85400
ADMA BIOLOGICS INCCOM00089910432,34016,584,802SH SOLE 16,584,80200
AGILE THERAPEUTICS INCCOM00847L10045,69015,919,925SH SOLE 15,919,92500
ALBIREO PHARMA INCCOM01345P10688,5292,360,139SH SOLE 2,360,13900
ALDEYRA THERAPEUTICS INCCOM01438T10643,1186,285,458SH SOLE 6,285,45800
ALLOGENE THERAPEUTICS INCCOM01977010628,8691,143,790SH SOLE 1,143,79000
AMERICAN WELL CORPCL A03044L10513,298525,000SH SOLE 525,00000
AMICUS THERAPEUTICS INCCOM03152W109579,83725,112,048SH SOLE 25,112,04800
AMYRIS INCCOM NEW03236M20020,5833,333,332SH SOLE 3,333,33200
ANAPTYSBIO INCCOM03272410625,7001,195,336SH SOLE 1,195,33600
ANAVEX LIFE SCIENCES CORPCOM NEW0327973004,212780,007SH SOLE 780,00700
AQUESTIVE THERAPEUTICS INCCOM03843E1047,4141,385,720SH SOLE 1,385,72000
ARENA PHARMACEUTICALS INCCOM NEW04004760744,178575,007SH SOLE 575,00700
ARROWHEAD PHARMACEUTICALS INCOM04280A10082,1641,070,814SH SOLE 1,070,81400
ATEA PHARMACEUTICALS INCCOM04683R106129,9033,109,224SH SOLE 3,109,22400
ATHENEX INCCOM04685N103149,66913,532,467SH SOLE 13,532,46700
ATHIRA PHARMA INCCOM04746L104106,6823,114,805SH SOLE 3,114,80500
AVIDITY BIOSCIENCES INCCOM05370A10831,5381,235,818SH SOLE 1,235,81800
BCLS ACQUISITION CORPCOM CL AG0904B10511,1401,000,000SH SOLE 1,000,00000
BCTG ACQUISITION CORPCOM05492W1035,720500,000SH SOLE 500,00000
BRIDGEBIO PHARMA INCCOM10806X102476,8836,706,268SH SOLE 6,706,26800
BURNING ROCK BIOTECH LTDSPONSORED ADS12233L1073,465150,000SH SOLE 150,00000
C4 THERAPEUTICS INCCOM STK12529R107104,6433,158,566SH SOLE 3,158,56600
CEREVEL THERAPEUTICS HLDNG ICOM15678U12875,3404,544,062SH SOLE 4,544,06200
COGENT BIOSCIENCES INCCOM19240Q20135,8103,188,750SH SOLE 3,188,75000
COHERUS BIOSCIENCES INCCOM19249H10381,1974,671,836SH SOLE 4,671,83600
COLLEGIUM PHARMACEUTICAL INCCOM19459J10441,2232,058,068SH SOLE 2,058,06800
COLLEGIUM PHARMACEUTICAL INCNOTE 2.625% 2/119459JAA2173,25017,500,000PRN SOLE 17,500,00000
COMPASS PATHWAYS PLCSPONSORED ADS20451W10149,8981,047,404SH SOLE 1,047,40400
CONCERT PHARMACEUTICALS INCCOM20602210527,1842,150,641SH SOLE 2,150,64100
CONSONANCE HFW ACQUISITION C UNIT 99/99/9999G2445M1295,235500,000SH SOLE 500,00000
CRINETICS PHARMACEUTICALS INCOM22663K10751,6343,659,381SH SOLE 3,659,38100
CURIS INCCOM NEW23126920010,2381,250,000SH SOLE 1,250,00000
CYTOMX THERAPEUTICS INCCOM23284F10516,8802,577,043SH SOLE 2,577,04300
DBV TECHNOLOGIES S ASPONSORED ADR23306J10117,2806,595,505SH SOLE 6,595,50500
DEERFIELD HEALTHCARE TECH ACCOM CL A24441310031220,000SH SOLE 20,00000
DEERFIELD HEALTHCARE TECH ACUNIT 07/16/20252444132094,500300,000SH SOLE 300,00000
DICERNA PHARMACEUTICALS INCCOM25303110817,624800,000SH SOLE 800,00000
DYNE THERAPEUTICS INC COM26818M1088,400400,000SH SOLE 400,00000
EIDOS THERAPEUTICS INCCOM28249H10490,385686,922SH SOLE 686,92200
EIGER BIOPHARMACEUTICALS INCCOM28249U1051,719139,890SH SOLE 139,89000
ESTABLISHMENT LABS HLDGS INCCOMG3124910826,221696,633SH SOLE 696,63300
FERRARI N VCOMN3167Y1031,4236,200SH SOLE 6,20000
FORMA THERAPEUTICS HLDGS INCSHS34633R10443,6251,250,000SH SOLE 1,250,00000
FORTE BIOSCIENCES INCCOM34962G10912,744350,000SH SOLE 350,00000
FREQUENCY THERAPEUTICS INCCOM35803L108114,9353,259,635SH SOLE 3,259,63500
FUSION PHARMACEUTICALS INCCOM36118A10026,2732,235,983SH SOLE 2,235,98300
GALERA THERAPEUTICS INCCOM36338D1083,325325,000SH SOLE 325,00000
GERON CORPCOM37416310321,40413,461,538SH SOLE 13,461,53800
GLOBAL BLOOD THERAPEUTICS INCOM37890U108245,7715,674,711SH SOLE 5,674,71100
HARMONY BIOSCIENCES HLDGS INCOM41319710418,170502,622SH SOLE 502,62200
HEALTH CATALYST INCCOM42225T10712,018276,084SH SOLE 276,08400
HEALTH SCIENCES ACQ CORP 2ORD SHSG4411D1095,765450,000SH SOLE 450,00000
HORIZON THERAPEUTICS PUB LSHSG46188101225,5973,084,042SH SOLE 3,084,04200
IMMATICS N.VSHSN4444510926,9752,500,000SH SOLE 2,500,00000
IMMUNOVANT INCCOM45258J10264,6661,400,000SH SOLE 1,400,00000
INARI MED INCCOM45332Y10958,353668,500SH SOLE 668,50000
INVITAE CORPCOM46185L103304,5637,284,466SH SOLE 7,284,46600
IOVANCE BIOTHERAPEUTICS INCCOM462260100425,3169,166,304SH SOLE 9,166,30400
IVERIC BIO INCCOM46583P10230,9764,482,713SH SOLE 4,482,71300
KADMON HLDGS INCCOM48283N10665,20215,711,334SH SOLE 15,711,33400
KODIAK SCIENCES INCCOM50015M109110,408751,533SH SOLE 751,53300
KRONOS BIO INCCOM50107A10483,0412,780,097SH SOLE 2,780,09700
LEAP THERAPEUTICS INCCOM52187K10119,0728,476,496SH SOLE 8,476,49600
LEGEND BIOTECH CORPSPONSORED ADS52490G10270425,000SH SOLE 25,00000
LIFESCI ACQUISITION II CORPCOM53229E1033,201300,000SH SOLE 300,00000
LONGVIEW ACQUISITION CORPUNIT 99/99/999954319520015,155700,000SH SOLE 700,00000
LYRA THERAPEUTICS INCCOM55234L10536,7373,222,561SH SOLE 3,222,56100
MACROGENICS INCCOM55609910928,8281,261,060SH SOLE 1,261,06000
MARAVAI LIFESCIENCES HLDGS ICOM LA A 56600D1079,818350,000SH SOLE 350,00000
MEIRAGTX HLDGS PLCCOMG59665102104,9706,933,277SH SOLE 6,933,27700
MIRATI THERAPEUTICS INCCOM60468T105811,2443,693,516SH SOLE 3,693,51600
MOLECULAR TEMPLATES INCCOM6085501093,867411,818SH SOLE 411,81800
MORPHIC HLDG INCCOM61775R10516,339487,000SH SOLE 487,00000
MOTUS GI HLDGS INCCOM62014P1083,9064,210,542SH SOLE 4,210,54200
NANOBIOTIX SASPONSORED ADS63009J10718,1501,100,000SH SOLE 1,100,00000
NANOSTRING TECHNOLOGIES INCCOM63009R10922,592337,800SH SOLE 337,80000
NEPTUNE WELLNESS SOLUTIONS ICOM64079L10534,65522,214,683SH SOLE 22,214,68300
NEUROCRINE BIOSCIENCES INCCOM64125C109182,0401,899,215SH SOLE 1,899,21500
NEVRO CORPCOM64157F103169,217977,565SH SOLE 977,56500
NEVRO CORPNOTE 2.750% 4/064157FAC7165,4209,000,000PRN SOLE 9,000,00000
NOVAVAX INCCOM NEW670002401116,3051,043,000SH SOLE 1,043,00000
ONCORUS INCCOM68236R10364,3361,989,987SH SOLE 1,989,98700
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20269012T11593420,875SH SOLE 420,87500
OUTSET MED INCCOM690145107161,8702,847,822SH SOLE 2,847,82200
PHREESIA INCCOM71944F1065,426100,000SH SOLE 100,00000
PMV PHARMACEUTICALS INCCOM69353Y10354,471885,556SH SOLE 885,55600
POSEIDA THERAPEUTICS INCCOM73730P1088,642787,745SH SOLE 787,74500
PROTAGONIST THERAPEUTICS INCCOM74366E1024,104203,591SH SOLE 203,59100
PROTARA THERAPEUTICS INCCOM STK74365U10714,733608,544SH SOLE 608,54400
PROVENTION BIO INCCOM74374N10271,5614,224,389SH SOLE 4,224,38900
PULMONX CORPCOM74584810126,573385,000SH SOLE 385,00000
QUOTIENT LTDSHSG7326810784,40616,200,818SH SOLE 16,200,81800
RAPT THERAPEUTICS INCCOM75382E10931,1551,577,481SH SOLE 1,577,48100
REGENERON PHARMACEUTICALSCOM75886F10726,65655,175SH SOLE 55,17500
RELAY THERAPEUTICS INC COM75943R10296,8102,329,407SH SOLE 2,329,40700
REPLIGEN CORPCOM75991610918,68497,500SH SOLE 97,50000
RETROPHIN INCNOTE 2.500% 9/1761299AB2442,52145,000,000PRN SOLE 45,000,00000
REVOLUTION MEDICINES INCCOM76155X1008,877224,224SH SOLE 224,22400
ROCKET PHARMACEUTICALS INCCOM77313F106186,2843,396,867SH SOLE 3,396,86700
SAGE THERAPEUTICS INCCOM78667J10838,064440,000SH SOLE 440,00000
SC HEALTH CORPUNIT 99/99/9999G7851630210,9901,000,000SH SOLE 1,000,00000
SCYNEXIS INCCOM NEW81129220018,3602,400,000SH SOLE 2,400,00000
SIERRA ONCOLOGY INCCOM NEW82640U4041,06866,655SH SOLE 66,65500
SIGILON THERAPEUTICS INCCOM82657L1076,004125,000SH SOLE 125,00000
SILK RD MED INCCOM82710M10029,292465,100SH SOLE 465,10000
SOCIAL CAPITAL HEDOSOPHIA HLDSHS CL AG8251L10567140,000SH SOLE 40,00000
SOLID BIOSCIENCES INCCOM83422E10581,89310,803,857SH SOLE 10,803,85700
SOTERA HEALTH COCOM83601L1028,232300,000SH SOLE 300,00000
SPDR SER TRS&P BIOTECH78464A87028,156200,000SHPutSOLE 200,00000
SPRINGWORKS THERAPEUTICS INCCOM85205L107302,9684,177,721SH SOLE 4,177,72100
STOKE THERAPEUTICS INCCOM86150R10741,616671,978SH SOLE 671,97800
SYNDAX PHARMACEUTICALS INCCOM87164F1056,672300,000SH SOLE 300,00000
TARSUS PHARMACEUTICALS INCCOM87650L10353,5801,296,416SH SOLE 1,296,41600
TAYSHA GENE THERAPIES INCCOM SHS87761910612,485470,440SH SOLE 470,44000
TCR2 THERAPEUTICS INCCOM87808K10612,372400,000SH SOLE 400,00000
THERAPEUTICS ACQUISITION CORCOM CL A88339T10320,8801,500,000SH SOLE 1,500,00000
TRAVERE THERAPEUTICS INCCOM89422G10795,2183,493,607SH SOLE 3,493,60700
UROVANT SCIENCES LTDSHSG9381B10850,2743,116,831SH SOLE 3,116,83100
VANECK VECTORS ETF TRPHARMACEUTICAL92189F69213,294200,000SHPutSOLE 200,00000
VAXCYTE INCCOM92243G10822,585850,000SH SOLE 850,00000
VBI VACCINES INCCOM NEW91822J103151,36655,042,465SH SOLE 55,042,46500
VERONA PHARMA PLCSPONSORED ADS92505010620,2222,888,889SH SOLE 2,888,88900
VERRICA PHARMACEUTICALS INCCOM92511W10839,2543,410,412SH SOLE 3,410,41200
VERU INCCOM92536C10328,1133,250,000SH SOLE 3,250,00000
VIATRIS INCCOM92556V10618,8231,004,419SH SOLE 1,004,41900
VIEWRAY INCCOM92672L1079,3662,451,748SH SOLE 2,451,74800
VINCERA PHARMA INCCOM92731L1066,273300,000SH SOLE 300,00000
VINCERA PHARMA INC*W EXP 12/24/20292731L114990300,000SH SOLE 300,00000
VYNE THERAPEUTICS INCCOM NEW92941V10036,14522,876,410SH SOLE 22,876,41000
WAVE LIFE SCIENCES LTDSHSY9530810519,6752,500,000SH SOLE 2,500,00000
ZENTALIS PHARMACEUTICALS INCCOM98943L10754,5371,050,003SH SOLE 1,050,00300
ZYMEWORKS INCCOM98985W102203,2654,300,999SH SOLE 4,300,99900