The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
1LIFE HEALTHCARE INCCOM68269G1077,936279,844SH SOLE 279,84400
ACCOLADE INCCOM00437E10211,394293,138SH SOLE 293,13800
ADAPTIMMUNE THERAPEUTICS PLCSPONDS ADR00653A1073,192400,000SH SOLE 400,00000
ADAPTIVE BIOTECHNOLOGIES CORCOM00650F10940,363830,000SH SOLE 830,00000
ADMA BIOLOGICS INCCOM00089910439,63816,584,802SH SOLE 16,584,80200
AGILE THERAPEUTICS INCCOM00847L10048,39715,919,925SH SOLE 15,919,92500
AKERO THERAPEUTICS INCCOM00973Y10867521,938SH SOLE 21,93800
ALBIREO PHARMA INCCOM01345P10678,7582,360,139SH SOLE 2,360,13900
ALDEYRA THERAPEUTICS INCCOM01438T10646,5756,285,458SH SOLE 6,285,45800
ALLOGENE THERAPEUTICS INCCOM01977010643,1321,143,790SH SOLE 1,143,79000
ALPHATEC HLDGS INCCOM NEW02081G2013,729561,574SH SOLE 561,57400
AMERICAN WELL CORPCL A03044L10513,486455,000SH SOLE 455,00000
AMICUS THERAPEUTICS INCCOM03152W109354,72325,122,048SH SOLE 25,122,04800
AMYRIS INCCOM NEW03236M2008,5683,333,332SH SOLE 3,333,33200
AQUESTIVE THERAPEUTICS INCCOM03843E1048,4961,750,000SH SOLE 1,750,00000
ARENA PHARMACEUTICALS INCCOM NEW04004760746,753625,129SH SOLE 625,12900
ATHENEX INCCOM04685N103161,32313,532,467SH SOLE 13,532,46700
ATHIRA PHARMA INCCOM04746L10457,4993,114,805SH SOLE 3,114,80500
ATRICURE INCCOM04963C2098,636216,449SH SOLE 216,44900
AVIDITY BIOSCIENCES INCCOM05370A10834,7881,235,818SH SOLE 1,235,81800
BCTG ACQUISITION CORPCOM05492W1035,180500,000SH SOLE 500,00000
BIO RAD LABS INCCL A090572207252489SH SOLE 48900
BIOGEN INCCOM09062X10328,368100,000SHCallSOLE 100,00000
BLUEPRINT MEDICINES CORPCOM09627Y10961,606664,574SH SOLE 664,57400
BRIDGEBIO PHARMA INCCOM10806X102251,6196,706,268SH SOLE 6,706,26800
BURNING ROCK BIOTECH LTDSPONSORED ADS12233L1073,762150,000SH SOLE 150,00000
CELLDEX THERAPEUTICS INC NEWCOM NEW15117B20273849,751SH SOLE 49,75100
COHERUS BIOSCIENCES INCCOM19249H10366,6933,636,485SH SOLE 3,636,48500
COLLEGIUM PHARMACEUTICAL INCCOM19459J10442,8492,058,068SH SOLE 2,058,06800
COLLEGIUM PHARMACEUTICAL INCNOTE 2.625% 2/119459JAA2163,76517,500,000PRN SOLE 17,500,00000
COMPASS PATHWAYS PLCSPONSORED ADS20451W10136,5541,047,404SH SOLE 1,047,40400
CONCERT PHARMACEUTICALS INCCOM20602210521,1192,150,641SH SOLE 2,150,64100
COVETRUS INCCOM22304C10063626,075SH SOLE 26,07500
CRINETICS PHARMACEUTICALS INCOM22663K10757,3423,659,381SH SOLE 3,659,38100
CRISPR THERAPEUTICS AGNAMEN AKTH17182108112,1871,341,308SH SOLE 1,341,30800
CYTOKINETICS INCNOTE 4.000%11/123282WAA8218,3019,770,000PRN SOLE 9,770,00000
CYTOMX THERAPEUTICS INCCOM23284F10517,1372,577,043SH SOLE 2,577,04300
DBV TECHNOLOGIES S ASPONSORED ADR23306J10111,7766,806,975SH SOLE 6,806,97500
DEERFIELD HEALTHCARE TECH ACUNIT 07/16/20252444132093,189300,000SH SOLE 300,00000
DICERNA PHARMACEUTICALS INCCOM25303110814,392800,000SH SOLE 800,00000
DYNE THERAPEUTICS INCCOM26818M1088,076400,000SH SOLE 400,00000
EIDOS THERAPEUTICS INCCOM28249H10434,710686,922SH SOLE 686,92200
EIGER BIOPHARMACEUTICALS INCCOM28249U1051,138139,890SH SOLE 139,89000
ESTABLISHMENT LABS HLDGS INCCOMG3124910812,575678,633SH SOLE 678,63300
FERRARI N VCOMN3167Y1031,1416,200SH SOLE 6,20000
FORMA THERAPEUTICS HLDGS INCSHS34633R10462,3001,250,000SH SOLE 1,250,00000
FREQUENCY THERAPEUTICS INCCOM35803L10862,5583,256,518SH SOLE 3,256,51800
FUSION PHARMACEUTICALS INCCOM36118A10026,8772,235,983SH SOLE 2,235,98300
GALERA THERAPEUTICS INCCOM36338D1082,938325,000SH SOLE 325,00000
GERON CORPCOM37416310323,42313,461,538SH SOLE 13,461,53800
GLOBAL BLOOD THERAPEUTICS INCOM37890U108319,8675,800,996SH SOLE 5,800,99600
HARMONY BIOSCIENCES HLDGS INCOM41319710414,759435,377SH SOLE 435,37700
HEALTH CATALYST INCCOM42225T10710,654291,084SH SOLE 291,08400
HEALTH SCIENCES ACQ CORP 2ORD SHSG4411D1094,950450,000SH SOLE 450,00000
HOLOGIC INCCOM43644010111,300170,000SH SOLE 170,00000
IMMATICS N.VSHSN4444510926,5252,500,000SH SOLE 2,500,00000
IMMUNOMEDICS INCCOM45290710877,559912,140SH SOLE 912,14000
IMMUNOVANT INCCOM45258J10249,2661,400,000SH SOLE 1,400,00000
INARI MED INCCOM45332Y10958,563848,500SH SOLE 848,50000
INSULET CORPCOM45784P1018,92737,733SH SOLE 37,73300
IOVANCE BIOTHERAPEUTICS INCCOM462260100332,01910,085,632SH SOLE 10,085,63200
IVERIC BIO INCCOM46583P10219,6353,481,431SH SOLE 3,481,43100
KADMON HLDGS INCCOM48283N10661,58815,711,334SH SOLE 15,711,33400
KODIAK SCIENCES INCCOM50015M10961,7571,043,021SH SOLE 1,043,02100
LEAP THERAPEUTICS INCCOM52187K10116,7838,476,496SH SOLE 8,476,49600
LEGEND BIOTECH CORPSPONSORED ADS52490G10277225,000SH SOLE 25,00000
LIFESCI ACQUISITION CORPUNIT 03/31/202553228P2084,080300,000SH SOLE 300,00000
LIVONGO HEALTH INCCOM5391831031,49310,663SH SOLE 10,66300
LONGVIEW ACQUISITION CORPUNIT 99/99/99995431952007,105700,000SH SOLE 700,00000
LYRA THERAPEUTICS INCCOM55234L10536,0283,222,561SH SOLE 3,222,56100
MACROGENICS INCCOM55609910932,5251,291,181SH SOLE 1,291,18100
MEIRAGTX HLDGS PLCCOMG5966510285,1766,433,277SH SOLE 6,433,27700
MIRATI THERAPEUTICS INCCOM60468T105570,4773,435,575SH SOLE 3,435,57500
MOLECULAR TEMPLATES INCCOM60855010927,0182,474,133SH SOLE 2,474,13300
MORPHIC HLDG INCCOM61775R10513,314487,000SH SOLE 487,00000
MOTUS GI HLDGS INCCOM62014P1084,0274,210,542SH SOLE 4,210,54200
MYLAN N.V SHS EURON5946510914,8951,004,419SH SOLE 1,004,41900
MYOKARDIA INCCOM62857M105190,1831,395,017SH SOLE 1,395,01700
NEPTUNE WELLNESS SOLUTIONS ICOM64079L10541,01219,436,906SH SOLE 19,436,90600
NEUROCRINE BIOSCIENCES INCCOM64125C109148,9241,548,715SH SOLE 1,548,71500
NEVRO CORPCOM64157F103115,085826,164SH SOLE 826,16400
NEVRO CORPNOTE 2.750% 4/064157FAC7141,8229,000,000PRN SOLE 9,000,00000
NOVAVAX INCCOM NEW67000240176,681707,715SH SOLE 707,71500
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20269012T11554420,875SH SOLE 420,87500
OUTSET MED INCCOM690145107142,3912,847,822SH SOLE 2,847,82200
PERSONALIS INCCOM71535D10659127,272SH SOLE 27,27200
PMV PHARMACEUTICALS INCCOM69353Y10321,497605,556SH SOLE 605,55600
POSEIDA THERAPEUTICS INCCOM73730P1086,987787,745SH SOLE 787,74500
PROTARA THERAPEUTICS INCCOM STK74365U10710,242608,544SH SOLE 608,54400
PROVENTION BIO INCCOM74374N10254,7294,265,711SH SOLE 4,265,71100
QUOTIENT LTDSHSG7326810783,27216,200,818SH SOLE 16,200,81800
REGENERON PHARMACEUTICALSCOM75886F1072,7995,000SH SOLE 5,00000
RELAY THERAPEUTICS INCCOM75943R10299,2092,329,407SH SOLE 2,329,40700
REPLIMUNE GROUP INCCOM76029N10644319,230SH SOLE 19,23000
RETROPHIN INCCOM76129910659,8123,240,112SH SOLE 3,240,11200
RETROPHIN INCNOTE 2.500% 9/1761299AB2390,11945,000,000PRN SOLE 45,000,00000
REVOLUTION MEDICINES INCCOM76155X1007,803224,224SH SOLE 224,22400
ROCKET PHARMACEUTICALS INCCOM77313F10650,0412,189,010SH SOLE 2,189,01000
SC HEALTH CORPUNIT 99/99/9999G7851630210,6001,000,000SH SOLE 1,000,00000
SIERRA ONCOLOGY INCCOM NEW82640U40471166,655SH SOLE 66,65500
SILK RD MED INCCOM82710M10034,956520,100SH SOLE 520,10000
SOLID BIOSCIENCES INCCOM83422E10513,7026,749,803SH SOLE 6,749,80300
SPDR SER TRS&P BIOTECH78464A87022,286200,000SHPutSOLE 200,00000
SPRINGWORKS THERAPEUTICS INCCOM85205L107165,9463,481,148SH SOLE 3,481,14800
STOKE THERAPEUTICS INCCOM86150R10722,505671,978SH SOLE 671,97800
TAYSHA GENE THERAPIES INCCOM SHS87761910610,538470,440SH SOLE 470,44000
TCR2 THERAPEUTICS INCCOM87808K1068,128400,000SH SOLE 400,00000
TG THERAPEUTICS INCCOM88322Q10890733,893SH SOLE 33,89300
THERAPEUTICS ACQUISITION CORCOM CL A88339T10321,5701,500,000SH SOLE 1,500,00000
TRANSLATE BIO INCCOM89374L1044,290315,237SH SOLE 315,23700
TRILLIUM THERAPEUTICS INCCOM NEW89620X5061,630114,674SH SOLE 114,67400
TURNING POINT THERAPEUTICS ICOM90041T10828,819329,890SH SOLE 329,89000
TWIST BIOSCIENCE CORPCOM90184D1008,566112,756SH SOLE 112,75600
UNUM THERAPEUTICS INCCOM90321410418,6157,955,000SH SOLE 7,955,00000
UROVANT SCIENCES LTDSHSG9381B10822,1062,366,831SH SOLE 2,366,83100
VANECK VECTORS ETF TRPHARMACEUTICAL92189F69212,434200,000SHPutSOLE 200,00000
VAXCYTE INCCOM92243G10841,973850,000SH SOLE 850,00000
VBI VACCINES INCCOM NEW91822J103157,42155,042,465SH SOLE 55,042,46500
VERONA PHARMA PLCSPONSORED ADS92505010618,0272,888,889SH SOLE 2,888,88900
VERRICA PHARMACEUTICALS INCCOM92511W10826,3973,410,412SH SOLE 3,410,41200
VERU INCCOM92536C1034,3231,650,000SH SOLE 1,650,00000
VIEWRAY INCCOM92672L1078,5812,451,748SH SOLE 2,451,74800
VYNE THERAPEUTICS INCCOM NEW92941V10037,97522,876,410SH SOLE 22,876,41000
WAVE LIFE SCIENCES LTDSHSY9530810521,2252,500,000SH SOLE 2,500,00000
ZENTALIS PHARMACEUTICALS INCCOM98943L10734,3251,050,003SH SOLE 1,050,00300
ZYMEWORKS INCCOM98985W102204,9994,400,999SH SOLE 4,400,99900