The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1LIFE HEALTHCARE INC COM 68269G107 7,948 218,844 SH   SOLE   218,844 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 4,004 400,000 SH   SOLE   400,000 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 23,222 480,000 SH   SOLE   480,000 0 0
ADMA BIOLOGICS INC COM 000899104 48,593 16,584,802 SH   SOLE   16,584,802 0 0
AGILE THERAPEUTICS INC COM 00847L100 44,257 15,919,925 SH   SOLE   15,919,925 0 0
AGIO PHARMACEUTICALS INC COM 00847X104 48,132 900,000 SH   SOLE   900,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 716 52,724 SH   SOLE   52,724 0 0
ALBIREO PHARMA INC COM 01345P106 51,924 1,960,139 SH   SOLE   1,960,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 12,866 3,085,458 SH   SOLE   3,085,458 0 0
ALECTOR INC COM 014442107 12,507 511,731 SH   SOLE   511,731 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 66,105 1,543,790 SH   SOLE   1,543,790 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 2,639 561,574 SH   SOLE   561,574 0 0
AMICUS THERAPEUTICS INC COM 03152W109 379,750 25,182,364 SH   SOLE   25,182,364 0 0
AMYRIS INC COM NEW 03236M200 6,449 1,844,612 SH   SOLE   1,844,612 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 373 11,418 SH   SOLE   11,418 0 0
AQUESTIVE THERAPEUTICS INC COM 03843E104 8,505 1,750,000 SH   SOLE   1,750,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 68,938 1,095,129 SH   SOLE   1,095,129 0 0
ATHENEX INC COM 04685N103 155,935 11,532,467 SH   SOLE   11,532,467 0 0
ATRICURE INC COM 04963C209 23,768 528,776 SH   SOLE   528,776 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 133 8,681 SH   SOLE   8,681 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 31,613 1,235,818 SH   SOLE   1,235,818 0 0
AXSOME THERAPEUTICS INC COM 05464T104 4,114 50,000 SH   SOLE   50,000 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 11,576 1,125,000 SH   SOLE   1,125,000 0 0
BIO RAD LABS INC CL A 090572207 6,993 15,489 SH   SOLE   15,489 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 43,996 1,104,656 SH   SOLE   1,104,656 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 53,713 688,624 SH   SOLE   688,624 0 0
BRIDGEBIO PHARMA INC COM 10806X102 218,691 6,706,268 SH   SOLE   6,706,268 0 0
BURNING ROCK BIOTECH LTD SPONSORED ADS 12233L107 4,052 150,000 SH   SOLE   150,000 0 0
CHEMOCENTRYX INC COM 16383L106 590 10,252 SH   SOLE   10,252 0 0
COHERUS BIOSCIENCES INC COM 19249H103 9,739 545,285 SH   SOLE   545,285 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 36,016 2,058,068 SH   SOLE   2,058,068 0 0
COLLEGIUM PHARMACEUTICAL INC NOTE 2.625% 2/1 19459JAA2 157,227 17,500,000 PRN   SOLE   17,500,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 21,398 2,150,641 SH   SOLE   2,150,641 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 59,171 3,659,381 SH   SOLE   3,659,381 0 0
CUE BIOPHARMA INC COM 22978P106 646 26,371 SH   SOLE   26,371 0 0
CYTOKINETICS INC NOTE 4.000%11/1 23282WAA8 238,260 10,000,000 PRN   SOLE   10,000,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 21,467 2,577,043 SH   SOLE   2,577,043 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 32,125 7,317,809 SH   SOLE   7,317,809 0 0
DENALI THERAPEUTICS INC COM 28423R105 20,553 850,000 SH   SOLE   850,000 0 0
DERMTECH INC COM 24984K105 6,445 487,121 SH   SOLE   487,121 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 20,320 800,000 SH   SOLE   800,000 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 1,570 176,950 SH   SOLE   176,950 0 0
EIDOS THERAPEUTICS INC COM 28249H104 30,115 686,922 SH   SOLE   686,922 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,343 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HOLDINGS INC SHS G31249108 13,750 736,121 SH   SOLE   736,121 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 58,113 1,250,000 SH   SOLE   1,250,000 0 0
FERRARI N.V SHS N3167Y103 1,060 6,200 SH   SOLE   6,200 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 70,547 3,034,296 SH   SOLE   3,034,296 0 0
FULCRUM THERAPEUTICS INC COM 359616109 15,768 894,118 SH   SOLE   894,118 0 0
FUSION PHARMACEUTICALS INC COM 36118A100 35,955 2,235,983 SH   SOLE   2,235,983 0 0
GALERA THERAPEUTICS INC COM 36338D108 2,321 325,000 SH   SOLE   325,000 0 0
GERON CORP COM 374163103 29,346 13,461,538 SH   SOLE   13,461,538 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 368,811 5,842,100 SH   SOLE   5,842,100 0 0
HEALTH CATALYST INC COM 42225T107 9,795 335,782 SH   SOLE   335,782 0 0
HOLOGIC INC COM 436440101 13,110 230,000 SH   SOLE   230,000 0 0
IMMUNOMEDICS INC COM 452907108 12,834 362,140 SH   SOLE   362,140 0 0
IMMUNOMEDICS INC COM 452907108 3,544 100,000 SH Put SOLE   100,000 0 0
IMMUNOVANT INC COM 45258J102 26,785 1,100,000 SH   SOLE   1,100,000 0 0
INARI MED INC COM 45332Y109 33,714 696,000 SH   SOLE   696,000 0 0
INSULET CORP COM 45784P101 10,244 52,733 SH   SOLE   52,733 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 324,170 11,809,494 SH   SOLE   11,809,494 0 0
IVERIC BIO INC COM 46583P102 17,755 3,481,431 SH   SOLE   3,481,431 0 0
KADMON HLDGS INC COM 48283N106 80,442 15,711,334 SH   SOLE   15,711,334 0 0
KARUNA THERAPEUTICS INC COM 48576A100 774 6,944 SH   SOLE   6,944 0 0
KODIAK SCIENCES INC COM 50015M109 190,154 3,513,572 SH   SOLE   3,513,572 0 0
LEAP THERAPEUTICS INC COM 52187K101 17,466 8,476,496 SH   SOLE   8,476,496 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 1,064 25,000 SH   SOLE   25,000 0 0
LIFESCI ACQUISITION CORP UNIT 03/31/2025 53228P208 3,300 300,000 SH   SOLE   300,000 0 0
LIVONGO HEALTH INC COM 539183103 1,024 13,620 SH   SOLE   13,620 0 0
LONGVIEW ACQUISITION CORP UNIT 99/99/9999 543195200 7,070 700,000 SH   SOLE   700,000 0 0
LUMINEX CORP DEL COM 55027E102 616 18,926 SH   SOLE   18,926 0 0
LYRA THERAPEUTICS INC COM 55234L105 36,543 3,222,561 SH   SOLE   3,222,561 0 0
MACROGENICS INC COM 556099109 35,961 1,288,014 SH   SOLE   1,288,014 0 0
MEDTRONIC PLC SHS G5960L103 1,834 20,000 SH   SOLE   20,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 80,544 6,433,277 SH   SOLE   6,433,277 0 0
MENLO THERAPEUTICS INC COM 586858102 39,576 22,876,410 SH   SOLE   22,876,410 0 0
MIRATI THERAPEUTICS INC COM 60468T105 316,371 2,771,050 SH   SOLE   2,771,050 0 0
MODERNA INC COM 60770K107 6,421 100,000 SH Put SOLE   100,000 0 0
MOLECULAR TEMPLATES INC COM 608550109 34,118 2,474,133 SH   SOLE   2,474,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 1,019 30,637 SH   SOLE   30,637 0 0
MORPHIC HLDG INC COM 61775R105 17,583 650,000 SH   SOLE   650,000 0 0
MOTUS GI HLDGS INC COM 62014P108 5,557 4,210,542 SH   SOLE   4,210,542 0 0
MYLAN N.V SHS EURO N59465109 16,151 1,004,419 SH   SOLE   1,004,419 0 0
MYOKARDIA INC COM 62857M105 134,787 1,395,017 SH   SOLE   1,395,017 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 8,921 537,425 SH   SOLE   537,425 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 51,623 18,436,906 SH   SOLE   18,436,906 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 261,252 2,141,410 SH   SOLE   2,141,410 0 0
NEVRO CORP COM 64157F103 107,520 899,972 SH   SOLE   899,972 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7 121,500 9,000,000 PRN   SOLE   9,000,000 0 0
NOVAVAX INC COM NEW 670002401 29,173 350,000 SH   SOLE   350,000 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 108 420,875 SH   SOLE   420,875 0 0
PHREESIA INC COM 71944F106 1,979 70,000 SH   SOLE   70,000 0 0
PROVENTION BIO INC COM 74374N102 63,858 4,525,711 SH   SOLE   4,525,711 0 0
QUOTIENT LTD COM G73268107 98,338 13,289,054 SH   SOLE   13,289,054 0 0
REGENERON PHARMACEUTICALS COM 75886F107 9,354 15,000 SH   SOLE   15,000 0 0
REPRO MED SYS INC COM 759910102 672 74,813 SH   SOLE   74,813 0 0
RETROPHIN INC COM 761299106 28,871 3,240,112 SH   SOLE   3,240,112 0 0
RETROPHIN INC NOTE 2.500% 9/1 761299AB2 349,979 45,000,000 PRN   SOLE   45,000,000 0 0
REVANCE THERAPEUTICS INC COM 761330109 1,608 65,839 SH   SOLE   65,839 0 0
REVOLUTION MEDICINES INC COM 76155X100 11,050 350,000 SH   SOLE   350,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 45,816 2,189,010 SH   SOLE   2,189,010 0 0
SC HEALTH CORP UNIT 99/99/9999 G78516302 10,110 1,000,000 SH   SOLE   1,000,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 807 66,655 SH   SOLE   66,655 0 0
SILK RD MED INC COM 82710M100 16,132 385,100 SH   SOLE   385,100 0 0
SOLID BIOSCIENCES INC COM 83422E105 19,777 6,749,803 SH   SOLE   6,749,803 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 147,603 3,514,358 SH   SOLE   3,514,358 0 0
STOKE THERAPEUTICS INC COM 86150R107 16,013 671,978 SH   SOLE   671,978 0 0
TG THERAPEUTICS INC COM 88322Q108 580 29,762 SH   SOLE   29,762 0 0
TRANSLATE BIO INC COM 89374L104 5,649 315,237 SH   SOLE   315,237 0 0
TRILLIUM THERAPEUTICS INC COM NEW 89620X506 928 114,674 SH   SOLE   114,674 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 21,308 329,890 SH   SOLE   329,890 0 0
TWIST BIOSCIENCE CORP COM 90184D100 12,356 272,756 SH   SOLE   272,756 0 0
UROVANT SCIENCES LTD COM G9381B108 23,289 2,366,831 SH   SOLE   2,366,831 0 0
VAPOTHERM INC COM 922107107 54,876 1,338,760 SH   SOLE   1,338,760 0 0
VAXCYTE INC COM 92243G108 26,869 850,000 SH   SOLE   850,000 0 0
VBI VACCINES INC COM NEW 91822J103 170,631 55,042,465 SH   SOLE   55,042,465 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 37,549 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 5,511 1,650,000 SH   SOLE   1,650,000 0 0
VIEWRAY INC COM 92672L107 5,492 2,451,748 SH   SOLE   2,451,748 0 0
VIR BIOTECHNOLOGY INC COM 92764N102 534 13,024 SH   SOLE   13,024 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 6,148 290,000 SH   SOLE   290,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 15,352 355,366 SH   SOLE   355,366 0 0
ZENTALIS PHARMACEUTICALS INC COM 98943L107 45,783 1,050,003 SH   SOLE   1,050,003 0 0
ZOGENIX INC COM NEW 98978L204 132,542 4,907,139 SH   SOLE   4,907,139 0 0
ZYMEWORKS INC COM 98985W102 129,166 3,580,999 SH   SOLE   3,580,999 0 0