The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X GENOMICS INC CLASS A COM88025U10913,816220,000SH SOLE 220,00000
1LIFE HEALTHCARE INC COM68269G1073,310185,000SH SOLE 185,00000
ABEONA THERAPEUTICS INC COM00289Y1073,0601,500,000SH SOLE 1,500,00000
ACCELERON PHARMA INC COM00434H1085836,813SH SOLE 6,81300
ADAPTIVE BIOTECHNOLOGIES CORPCOM00650F10913,424495,000SH SOLE 495,00000
ADMA BIOLOGICS INC COM00089910447,76416,584,802SH SOLE 16,584,80200
AGILE THERAPEUTICS INC COM00847L10029,61115,919,325SH SOLE 15,919,32500
AGIOS PHARMACEUTICALS INC COM00847X10431,860900,000SH SOLE 900,00000
ALBIREO PHARMA INC COM01345P10631,9311,960,139SH SOLE 1,960,13900
ALDEYRA THERAPEUTICS INCCOM01438T1067,6213,085,458SH SOLE 3,085,45800
ALECTOR INC COM01444210712,348511,731SH SOLE 511,73100
ALLOGENE THERAPEUTICS INC COM01977010630,0111,543,790SH SOLE 1,543,79000
ALPHATEC HOLDINGS INC COM02081G2012,021561,574SH SOLE 561,57400
AMICUS THERAPEUTICS INC COM03152W109232,68525,182,364SH SOLE 25,182,36400
ANAPTYSBIO INC COM0327241067,070500,000SH SOLE 500,00000
APELLIS PHARMACEUTICALS INC COM03753U10632711,418SH SOLE 11,41800
AQUESTIVE THERAPEUTICS INC COM3843E10473,8331,750,000SH SOLE 1,750,00000
ARENA PHARMACEUTICALS INC COM04004760728,356675,129SH SOLE 675,12900
ARTARA THERAPEUTICS INC COM04300J1071848,543SH SOLE 8,54300
ATHENEX INC COM04685N10389,26111,532,467SH SOLE 11,532,46700
ATRICURE INC COM04963C20910,152302,227SH SOLE 302,22700
AVADEL PHARMACEUTICALS PLC ADR05337M104768,681SH SOLE 8,68100
AXONICS MODULATION TECHNOLOGIES INC COM05465P1011,18850,000SH SOLE 50,00000
BIO-RAD LABORATORIES INC COM0905722071,2183,489SH SOLE 3,48900
BLACK DIAMOND THERAPEUTICS INC COM09203E10527,5611,104,656SH SOLE 1,104,65600
BLUEPRINT MEDICINES CORP COM09627Y10940,271688,624SH SOLE 688,62400
BRIDGEBIO PHARMA INC COM10806X102194,4816,706,268SH SOLE 6,706,26800
CERNER CORP COM1567821046,745105,000SH SOLE 105,00000
CHEMOCENTRYX INC COM16383L10640610,252SH SOLE 10,25200
COLLEGIUM PHARMACEUTICAL INC COM19459J10425,3391,551,722SH SOLE 1,551,72200
CONCERT PHARMACEUTICALS INC COM20602210519,5492,150,641SH SOLE 2,150,64100
CRINETICS PHARMACEUTICALS INC COM22663K10738,0422,587,953SH SOLE 2,587,95300
CUE BIOPHARMA INC COM22978P10636226,371SH SOLE 26,37100
CYTOMX THERAPEUTICS INC COM23284F10524,9583,253,923SH SOLE 3,253,92300
DBV TECHNOLOGIES SA SPONSORED ADR23306J10128,6857,317,809SH SOLE 7,317,80900
DENALI THERAPEUTICS INC COM24823R10514,884850,000SH SOLE 850,00000
DERMTECH INCCOM24984K1053,215285,856SH SOLE 285,85600
EIDOS THERAPEUTICS INC COM28249H10433,652686,922SH SOLE 686,92200
EIGER BIOPHARMACEUTICALS INC COM28249U105951139,890SH SOLE 139,89000
ESTABLISHMENT LABS HOLDINGS INC COMG3124910813,332922,633SH SOLE 922,63300
FERRARI N.V.COMN3167Y1039576,200SH SOLE 6,20000
FREQUENCY THERAPEUTICS INC COM35803L10854,0403,034,296SH SOLE 3,034,29600
FULCRUM THERAPEUTICS INC COM3596161097,164600,000SH SOLE 600,00000
GALERA THERAPEUTICS INC COM36338D1083,088325,000SH SOLE 325,00000
GILEAD SCIENCES INC COM37555810311,2141,500,000SH SOLE 1,500,00000
GLOBAL BLOOD THERAPEUTICS INC COM37890U108309,8976,065,726SH SOLE 6,065,72600
HEALTH CATALYST INC COM42225T1078,375328,698SH SOLE 328,69800
IDEAYA BIOSCIENCES INC COM45166A1024,7021,141,484SH SOLE 1,141,48400
IMMUNOVANT INC UNIT 12/18/202445258J2017,356400,000SH SOLE 400,00000
INSULET CORP COM45784P10113,70882,733SH SOLE 82,73300
IOVANCE BIOTHERAPEUTICS INC COM462260100349,34311,670,057SH SOLE 11,670,05700
IVERIC BIO INC COM46583P1024,7381,377,289SH SOLE 1,377,28900
KADMON HOLDINGS INC COM48283N10665,83015,711,334SH SOLE 15,711,33400
KARUNA THERAPEUTICS INC COM48576A1004976,944SH SOLE 6,94400
KODIAK SCIENCES INC COM50015M109174,7523,663,557SH SOLE 3,663,55700
LEAP THERAPEUTICS INC COM 52187K10110,6276,726,496SH SOLE 6,726,49600
LIFESCI ACQUISITION CORP UNIT 3/31/202553228P2082,940300,000SH SOLE 300,00000
LUMINEX CORP COM5027E102950018,926SH SOLE 18,92600
MEI PHARMA INCCOM NEW55279B2024,8793,030,440SH SOLE 3,030,44000
MEIRAGTX HOLDINGS PLC COMG5966510286,4636,433,277SH SOLE 6,433,27700
MENLO THERAPEUTICS INCCOM58685810217,4566,637,179SH SOLE 6,637,17900
MEREO BIOPHARMA GROUP PLCADS589492107187179,419SH SOLE 179,41900
MIRATI THERAPEUTICS INC COM60468T105149100,000SHPutSOLE 100,00000
MIRATI THERAPEUTICS INC COM60468T105255,1673,319,450SH SOLE 3,319,45000
MOLECULAR TEMPLATES INCCOM60855010932,8822,474,133SH SOLE 2,474,13300
MOMENTA PHARMACEUTICALS INC COM60877T10088130,637SH SOLE 30,63700
MORPHIC HOLDING INC COM61775R1059,542650,000SH SOLE 650,00000
MOTUS GI HLDGS INC COM62014P1082,8374,210,542SH SOLE 4,210,54200
MYLAN N.V. SHS EURO N594651096,028400,000SH SOLE 400,00000
MYOKARDIA INC COM62857M10561,6111,314,209SH SOLE 1,314,20900
NEOLEUKIN THERAPEUTICS INC COM64049K1045,535500,000SH SOLE 500,00000
NEPTUNE WELLNESS SOLUTIONS INC COM64079L10515,72113,436,906SH SOLE 13,436,90600
NEUROCRINE BIOSCIENCES INC COM64125C109265,1263,063,263SH SOLE 3,063,26300
NEVRO CORP COM64157F103107,4491,092,068SH SOLE 1,092,06800
OUTLOOK THERAPEUTICS INCW EXP 02/18/20269012T11546420,875SH SOLE 420,87500
PHREESIA INC COM71944F1061,42470,000SH SOLE 70,00000
PROVENTION BIO INC COM74374N10227,7073,011,574SH SOLE 3,011,57400
QUOTIENT LTD COMG7326810752,49113,289,054SH SOLE 13,289,05400
REGENERON PHARMACEUTICALS INC COM75886F10739,06380,000SH SOLE 80,00000
REGENXBIO INC COM75901B10717,145508,000SH SOLE 508,00000
REPRO MED SYS INC COM75991010253774,813SH SOLE 74,81300
RESTORBIO INC COM76133L103109,306SH SOLE 9,30600
RETROPHIN INCNOTE 2.500% 9/1761299AB235,01645,000,000PRN SOLE 45,000,00000
RETROPHIN INC COM76129910642,1732,890,608SH SOLE 2,890,60800
REVANCE THERAPEUTICS INC COM76133010913,690925,000SH SOLE 925,00000
REVOLUTION MEDICINES INC COM76155X1007,816350,000SH SOLE 350,00000
RHYTHM PHARMACEUTICALS INC COM76243J1052,600170,859SH SOLE 170,85900
ROCKET PHARMACEUTICALS INC COM77313F10630,5372,189,010SH SOLE 2,189,01000
SC HEALTH CORP UNIT 99/99/9999G7851630210,0001,000,000SH SOLE 1,000,00000
SCHRODINGER INC COM80810D10310,545250,000SH SOLE 250,00000
SIERRA ONCOLOGY INC COM82640U40466466,654SH SOLE 66,65400
SILK ROAD MEDICAL INC COM82710M1006,639204,600SH SOLE 204,60000
SOLID BIOSCIENCES INC COM3422E105516,1326,749,803SH SOLE 6,749,80300
SPDR S&P 500 ETF TRTR UNIT 78462F103159325,000SHCallSOLE 325,00000
SPRINGWORKS THERAPEUTICS INC COM85205L10794,0783,484,358SH SOLE 3,484,35800
STOKE THERAPEUTICS INC COM86150R10715,388671,978SH SOLE 671,97800
THERAPEUTICSMD INCCOM88338N1071,1731,096,101SH SOLE 1,096,10100
THERAVANCE BIOPHARMA INC COMG8807B10623,1101,000,000SH SOLE 1,000,00000
TRANSLATE BIO INC COM89374L1044,994435,000SH SOLE 435,00000
TURNING POINT THERAPEUTICS INC COM90041T10815,441349,890SH SOLE 349,89000
TWIST BIOSCIENCE CORPCOM90184D10010,380322,356SH SOLE 322,35600
UROVANT SCIENCES LTD COMG9381B10821,8232,366,831SH SOLE 2,366,83100
VAPOTHERM INC COM92210710731,4471,670,067SH SOLE 1,670,06700
VBI VACCINES INC COM91822J10343,65345,951,556SH SOLE 45,951,55600
VERRICA PHARMACEUTICALS INC COM92511W10837,2753,410,412SH SOLE 3,410,41200
VERU INC REGISTERED SHSCOM92536C1035,3961,650,000SH SOLE 1,650,00000
VIEWRAY INC COM92672L1075,7132,451,748SH SOLE 2,451,74800
VOCERA COMMUNICATIONS INC COM92857F10710,298470,000SH SOLE 470,00000
Y-MABS THERAPEUTICS INCCOM98424110912,085522,480SH SOLE 522,48000
ZIMMER BIOMET HOLDINGS INCCOM98956P1024,91450,000SH SOLE 50,00000
ZOGENIX INC COM98978L20485,3903,452,921SH SOLE 3,452,92100
ZOGENIX INC COM98978L204724300,000SHPutSOLE 300,00000
ZYMEWORKS INC COM98985W102126,0923,560,999SH SOLE 3,560,99900