The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CLASS A COM 88025U109 16,775 220,000 SH   SOLE   220,000 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 4,905 1,500,000 SH   SOLE   1,500,000 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 482 11,256 SH   SOLE   11,256 0 0
ACASTI PHARMA INC COM 00430K402 4,361 1,779,882 SH   SOLE   1,779,882 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 9,126 305,000 SH   SOLE   305,000 0 0
ADMA BIOLOGICS INC COM 000899104 46,084 11,521,102 SH   SOLE   11,521,102 0 0
AGILE THERAPEUTICS INC COM 00847L100 29,799 11,919,925 SH   SOLE   11,919,925 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 42,975 900,000 SH   SOLE   900,000 0 0
ALBIREO PHARMA INC COM 01345P106 43,324 1,704,330 SH   SOLE   1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 17,926 3,085,458 SH   SOLE   3,085,458 0 0
ALECTOR INC COM 014442107 8,817 511,731 SH   SOLE   511,731 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 40,107 1,543,790 SH   SOLE   1,543,790 0 0
ALPHATEC HOLDINGS INC COM 02081G201 3,984 561,574 SH   SOLE   561,574 0 0
AMARIN CORPORATION PLC SPONS ADR NEW 023111206 152,355 7,106,079 SH   SOLE   7,106,079 0 0
AMICUS THERAPEUTICS INC COM 03152W109 244,789 25,132,364 SH   SOLE   25,132,364 0 0
ANAPTYSBIO INC COM 032724106 16,250 1,000,000 SH   SOLE   1,000,000 0 0
AQUESTIVE THERAPEUTICS INC COM 3843E1047 13,095 2,250,000 SH   SOLE   2,250,000 0 0
ARAVIVE INC COM 03890D108 450 32,895 SH   SOLE   32,895 0 0
ARENA PHARMACEUTICALS INC COM 040047607 43,291 953,129 SH   SOLE   953,129 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 1,950 30,738 SH   SOLE   30,738 0 0
ARVINAS INC COM 04335A105 16,436 400,000 SH   SOLE   400,000 0 0
ATHENEX INC COM 04685N103 176,100 11,532,467 SH   SOLE   11,532,467 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 14,520 716,666 SH   SOLE   716,666 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 66 8,681 SH   SOLE   8,681 0 0
AXONICS MODULATION TECH INC COM 05465P101 1,524 55,000 SH   SOLE   55,000 0 0
BEIGENE LTD SPONSORED ADR 07725L102 4 200,000 SH Put SOLE   200,000 0 0
BIO-RAD LABORATORIES INC CL A 090572207 25,343 68,489 SH   SOLE   68,489 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 49,558 618,624 SH   SOLE   618,624 0 0
BRIDGEBIO PHARMA INC COM 10806X102 142,273 6,706,268 SH   SOLE   6,706,268 0 0
CERNER CORP COM 156782104 7,706 105,000 SH   SOLE   105,000 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 8,670 421,272 SH   SOLE   421,272 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 19,840 2,150,641 SH   SOLE   2,150,641 0 0
CONSTELLATION PHARMCETICLS INC COM 210373106 283 6,000 SH   SOLE   6,000 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 64,931 2,587,953 SH   SOLE   2,587,953 0 0
CRYOLIFE INC COM 228903100 1,355 50,000 SH   SOLE   50,000 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 27,040 3,253,923 SH   SOLE   3,253,923 0 0
DBV TECHNOLOGIES SA SPONSORED ADR 23306J101 46,735 4,367,809 SH   SOLE   4,367,809 0 0
DECIPHERA PHARMACEUTICALS INC COM 24344T101 892 14,326 SH   SOLE   14,326 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 804 36,496 SH   SOLE   36,496 0 0
EHEALTH INC COM 28238P109 18,997 197,720 SH   SOLE   197,720 0 0
EIDOS THERAPEUTICS INC COM 28249H104 40,030 697,524 SH   SOLE   697,524 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,084 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HOLDINGS INC COM G31249108 29,057 1,050,528 SH   SOLE   1,050,528 0 0
FERRARI N.V. COM N3167Y103 1,026 6,200 SH   SOLE   6,200 0 0
FOAMIX PHARMACEUTICALS LTD COM M46135105 37,309 11,203,881 SH   SOLE   11,203,881 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 49,812 3,034,296 SH   SOLE   3,034,296 0 0
FULCRUM THERAPEUTICS INC COM 359616109 9,984 600,000 SH   SOLE   600,000 0 0
GALERA THERAPEUTICS INC COM 36338D108 4,277 325,000 SH   SOLE   325,000 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 466,266 5,865,726 SH   SOLE   5,865,726 0 0
HEALTH CATALYST INC COM 42225T107 9,844 283,698 SH   SOLE   283,698 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 8,561 1,141,484 SH   SOLE   1,141,484 0 0
IMMUNOVANT INC UNIT 12/18/2024 45258J201 9,948 400,000 SH   SOLE   400,000 0 0
INTERCEPT PHARMACEUTICALS INC COM 45845P108 12,095 97,600 SH   SOLE   97,600 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 28,575 800,600 SH Call SOLE   800,600 0 0
INVITAE CORP COM 46185L103 5,425 336,308 SH   SOLE   336,308 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 260,640 9,416,202 SH   SOLE   9,416,202 0 0
IVERIC BIO INC COM 46583P102 8,497 990,289 SH   SOLE   990,289 0 0
KADMON HOLDINGS INC COM 48283N106 66,302 14,636,334 SH   SOLE   14,636,334 0 0
KARUNA THERAPEUTICS INC COM 48576A100 523 6,944 SH   SOLE   6,944 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 1,048 54,645 SH   SOLE   54,645 0 0
KODIAK SCIENCES INC COM 50015M109 263,593 3,663,557 SH   SOLE   3,663,557 0 0
MEI PHARMA INC COM NEW 552996456 10,913 4,400,440 SH   SOLE   4,400,440 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 128,794 6,433,277 SH   SOLE   6,433,277 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 588 179,419 SH   SOLE   179,419 0 0
MIRATI THERAPEUTICS INC COM 60468T105 412,791 3,203,406 SH   SOLE   3,203,406 0 0
MOLECULAR TEMPLATES INC COM 608550109 34,601 2,474,133 SH   SOLE   2,474,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 55,947 2,835,637 SH   SOLE   2,835,637 0 0
MORPHIC HOLDING INC COM 61775R105 11,154 650,000 SH   SOLE   650,000 0 0
MOTUS GI HLDGS INC COM 62014P108 9,642 4,210,542 SH   SOLE   4,210,542 0 0
MYOKARDIA INC COM 62857M105 87,929 1,206,411 SH   SOLE   1,206,411 0 0
NATERA INC COM 632307104 490 14,549 SH   SOLE   14,549 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 6,160 500,000 SH   SOLE   500,000 0 0
NEPTUNE WELLNESS SOLUTIONS INC COM 64079L105 36,752 13,436,906 SH   SOLE   13,436,906 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 388,313 3,612,554 SH   SOLE   3,612,554 0 0
NEVRO CORP COM 64157F103 89,787 763,886 SH   SOLE   763,886 0 0
NOVOCURE LTD COM G6674U108 800 9,489 SH   SOLE   9,489 0 0
OPTINOSE INC COM 68404V100 535 58,005 SH   SOLE   58,005 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 33 420,875 SH   SOLE   420,875 0 0
PHREESIA INC COM 71944F106 1,865 70,000 SH   SOLE   70,000 0 0
PROTEON THERAPEUTICS INC COM 74371L109 140 341,743 SH   SOLE   341,743 0 0
PROVENTION BIO INC COM 74374N102 43,532 2,921,574 SH   SOLE   2,921,574 0 0
QUOTIENT LTD COM G73268107 126,378 13,289,054 SH   SOLE   13,289,054 0 0
REGENXBIO INC COM 75901B107 24,910 608,000 SH   SOLE   608,000 0 0
REPRO MED SYS INC COM 759910102 489 74,813 SH   SOLE   74,813 0 0
RESTORBIO INC COM 76133L103 14 9,306 SH   SOLE   9,306 0 0
RETROPHIN INC COM 761299106 41,046 2,890,608 SH   SOLE   2,890,608 0 0
REVANCE THERAPEUTICS INC COM 761330109 13,315 820,377 SH   SOLE   820,377 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 3,922 170,859 SH   SOLE   170,859 0 0
ROCKET PHARMACUETICALS INC COM 77313F106 50,965 2,239,241 SH   SOLE   2,239,241 0 0
SC HEALTH CORP UNIT 99/99/9999 G78516302 10,360 1,000,000 SH   SOLE   1,000,000 0 0
SELECT INTERIOR CONCEPTS INC COM 816120307 945 105,105 SH   SOLE   105,105 0 0
SHOCKWAVE MED INC COM 82489T104 1,318 30,000 SH   SOLE   30,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 910 2,666,190 SH   SOLE   2,666,190 0 0
SOLID BIOSCIENCES INC COM 3422E1055 30,036 6,749,803 SH   SOLE   6,749,803 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 1,558 1,000,000 SH Put SOLE   1,000,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 128,461 3,337,522 SH   SOLE   3,337,522 0 0
STOKE THERAPEUTICS INC COM 86150R107 19,030 671,978 SH   SOLE   671,978 0 0
TANDEM DIABETES CARE INC COM 875372203 18,479 310,000 SH   SOLE   310,000 0 0
THERAPEUTICSMD INC COM 88338N107 2,653 1,096,101 SH   SOLE   1,096,101 0 0
TRANSLATE BIO INC COM 89374L104 3,541 435,000 SH   SOLE   435,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 27,245 437,390 SH   SOLE   437,390 0 0
TWIST BIOSCIENCE CORP COM 90184D100 4,533 215,856 SH   SOLE   215,856 0 0
UROVANT SCIENCES LTD COM G9381B108 37,331 2,406,931 SH   SOLE   2,406,931 0 0
VAPOTHERM INC COM 922107107 21,204 1,743,767 SH   SOLE   1,743,767 0 0
VBI VACCINES INC COM 91822J103 63,413 45,951,556 SH   SOLE   45,951,556 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 52,022 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 5,528 1,650,000 SH   SOLE   1,650,000 0 0
VIEWRAY INC COM 92672L107 10,346 2,451,748 SH   SOLE   2,451,748 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 6,154 296,420 SH   SOLE   296,420 0 0
Y-MABS THERAPEUTICS INC COM 984241109 17,570 562,237 SH   SOLE   562,237 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 7,484 50,000 SH   SOLE   50,000 0 0
ZOGENIX INC COM 98978L204 193,358 3,709,152 SH   SOLE   3,709,152 0 0
ZYMEWORKS INC COM 98985W102 109,241 2,403,026 SH   SOLE   2,403,026 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 790 200,000 SH Put SOLE   200,000 0 0