The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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OMB Number:3235-0006
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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X GENOMICS INC CLASS A COM88025U10916,775220,000SH SOLE 220,00000
ABEONA THERAPEUTICS INC COM00289Y1074,9051,500,000SH SOLE 1,500,00000
ACADIA PHARMACEUTICALS INC COM00422510848211,256SH SOLE 11,25600
ACASTI PHARMA INC COM00430K4024,3611,779,882SH SOLE 1,779,88200
ADAPTIVE BIOTECHNOLOGIES CORCOM00650F1099,126305,000SH SOLE 305,00000
ADMA BIOLOGICS INCCOM00089910446,08411,521,102SH SOLE 11,521,10200
AGILE THERAPEUTICS INC COM00847L10029,79911,919,925SH SOLE 11,919,92500
AGIOS PHARMACEUTICALS INC COM00847X10442,975900,000SH SOLE 900,00000
ALBIREO PHARMA INC COM01345P10643,3241,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INCCOM01438T10617,9263,085,458SH SOLE 3,085,45800
ALECTOR INC COM0144421078,817511,731SH SOLE 511,73100
ALLOGENE THERAPEUTICS INC COM01977010640,1071,543,790SH SOLE 1,543,79000
ALPHATEC HOLDINGS INC COM02081G2013,984561,574SH SOLE 561,57400
AMARIN CORPORATION PLC SPONS ADR NEW 023111206152,3557,106,079SH SOLE 7,106,07900
AMICUS THERAPEUTICS INC COM03152W109244,78925,132,364SH SOLE 25,132,36400
ANAPTYSBIO INC COM03272410616,2501,000,000SH SOLE 1,000,00000
AQUESTIVE THERAPEUTICS INC COM3843E104713,0952,250,000SH SOLE 2,250,00000
ARAVIVE INC COM03890D10845032,895SH SOLE 32,89500
ARENA PHARMACEUTICALS INCCOM04004760743,291953,129SH SOLE 953,12900
ARROWHEAD PHARMACEUTICALS INC COM04280A1001,95030,738SH SOLE 30,73800
ARVINAS INC COM04335A10516,436400,000SH SOLE 400,00000
ATHENEX INC COM04685N103176,10011,532,467SH SOLE 11,532,46700
AURINIA PHARMACEUTICALS INC COM05156V10214,520716,666SH SOLE 716,66600
AVADEL PHARMACEUTICALS PLC SPONSORED ADR05337M104668,681SH SOLE 8,68100
AXONICS MODULATION TECH INC COM05465P1011,52455,000SH SOLE 55,00000
BEIGENE LTD SPONSORED ADR07725L1024200,000SHPutSOLE 200,00000
BIO-RAD LABORATORIES INC CL A 09057220725,34368,489SH SOLE 68,48900
BLUEPRINT MEDICINES CORP COM09627Y10949,558618,624SH SOLE 618,62400
BRIDGEBIO PHARMA INC COM10806X102142,2736,706,268SH SOLE 6,706,26800
CERNER CORP COM1567821047,706105,000SH SOLE 105,00000
COLLEGIUM PHARMACEUTICAL INC COM19459J1048,670421,272SH SOLE 421,27200
CONCERT PHARMACEUTICALS INC COM20602210519,8402,150,641SH SOLE 2,150,64100
CONSTELLATION PHARMCETICLS INC COM2103731062836,000SH SOLE 6,00000
CRINETICS PHARMACEUTICALS INC COM22663K10764,9312,587,953SH SOLE 2,587,95300
CRYOLIFE INC COM2289031001,35550,000SH SOLE 50,00000
CYTOMX THERAPEUTICS INC COM23284F10527,0403,253,923SH SOLE 3,253,92300
DBV TECHNOLOGIES SA SPONSORED ADR23306J10146,7354,367,809SH SOLE 4,367,80900
DECIPHERA PHARMACEUTICALS INC COM24344T10189214,326SH SOLE 14,32600
DICERNA PHARMACEUTICALS INCCOM25303110880436,496SH SOLE 36,49600
EHEALTH INC COM28238P10918,997197,720SH SOLE 197,72000
EIDOS THERAPEUTICS INC COM28249H10440,030697,524SH SOLE 697,52400
EIGER BIOPHARMACEUTICALS INC COM28249U1052,084139,890SH SOLE 139,89000
ESTABLISHMENT LABS HOLDINGS INCCOMG3124910829,0571,050,528SH SOLE 1,050,52800
FERRARI N.V. COMN3167Y1031,0266,200SH SOLE 6,20000
FOAMIX PHARMACEUTICALS LTD COMM4613510537,30911,203,881SH SOLE 11,203,88100
FREQUENCY THERAPEUTICS INC COM35803L10849,8123,034,296SH SOLE 3,034,29600
FULCRUM THERAPEUTICS INC COM3596161099,984600,000SH SOLE 600,00000
GALERA THERAPEUTICS INC COM36338D1084,277325,000SH SOLE 325,00000
GLOBAL BLOOD THERAPEUTICS INC COM37890U108466,2665,865,726SH SOLE 5,865,72600
HEALTH CATALYST INC COM42225T1079,844283,698SH SOLE 283,69800
IDEAYA BIOSCIENCES INC COM45166A1028,5611,141,484SH SOLE 1,141,48400
IMMUNOVANT INC UNIT 12/18/2024 45258J2019,948400,000SH SOLE 400,00000
INTERCEPT PHARMACEUTICALS INC COM45845P10812,09597,600SH SOLE 97,60000
INTRA-CELLULAR THERAPIES INC COM46116X10128,575800,600SHCallSOLE 800,60000
INVITAE CORP COM46185L1035,425336,308SH SOLE 336,30800
IOVANCE BIOTHERAPEUTICS INC COM462260100260,6409,416,202SH SOLE 9,416,20200
IVERIC BIO INC COM46583P1028,497990,289SH SOLE 990,28900
KADMON HOLDINGS INC COM48283N10666,30214,636,334SH SOLE 14,636,33400
KARUNA THERAPEUTICS INCCOM48576A1005236,944SH SOLE 6,94400
KARYOPHARM THERAPEUTICS INC COM48576U1061,04854,645SH SOLE 54,64500
KODIAK SCIENCES INC COM50015M109263,5933,663,557SH SOLE 3,663,55700
MEI PHARMA INC COM NEW 55299645610,9134,400,440SH SOLE 4,400,44000
MEIRAGTX HOLDINGS PLC COMG59665102128,7946,433,277SH SOLE 6,433,27700
MEREO BIOPHARMA GROUP PLC ADS589492107588179,419SH SOLE 179,41900
MIRATI THERAPEUTICS INC COM60468T105412,7913,203,406SH SOLE 3,203,40600
MOLECULAR TEMPLATES INC COM60855010934,6012,474,133SH SOLE 2,474,13300
MOMENTA PHARMACEUTICALS INC COM60877T10055,9472,835,637SH SOLE 2,835,63700
MORPHIC HOLDING INC COM61775R10511,154650,000SH SOLE 650,00000
MOTUS GI HLDGS INC COM62014P1089,6424,210,542SH SOLE 4,210,54200
MYOKARDIA INC COM62857M10587,9291,206,411SH SOLE 1,206,41100
NATERA INCCOM63230710449014,549SH SOLE 14,54900
NEOLEUKIN THERAPEUTICS INC COM64049K1046,160500,000SH SOLE 500,00000
NEPTUNE WELLNESS SOLUTIONS INC COM64079L10536,75213,436,906SH SOLE 13,436,90600
NEUROCRINE BIOSCIENCES INC COM64125C109388,3133,612,554SH SOLE 3,612,55400
NEVRO CORP COM64157F10389,787763,886SH SOLE 763,88600
NOVOCURE LTDCOMG6674U1088009,489SH SOLE 9,48900
OPTINOSE INC COM68404V10053558,005SH SOLE 58,00500
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20269012T11533420,875SH SOLE 420,87500
PHREESIA INC COM71944F1061,86570,000SH SOLE 70,00000
PROTEON THERAPEUTICS INC COM74371L109140341,743SH SOLE 341,74300
PROVENTION BIO INC COM74374N10243,5322,921,574SH SOLE 2,921,57400
QUOTIENT LTD COMG73268107126,37813,289,054SH SOLE 13,289,05400
REGENXBIO INCCOM75901B10724,910608,000SH SOLE 608,00000
REPRO MED SYS INC COM75991010248974,813SH SOLE 74,81300
RESTORBIO INC COM76133L103149,306SH SOLE 9,30600
RETROPHIN INC COM76129910641,0462,890,608SH SOLE 2,890,60800
REVANCE THERAPEUTICS INC COM76133010913,315820,377SH SOLE 820,37700
RHYTHM PHARMACEUTICALS INC COM76243J1053,922170,859SH SOLE 170,85900
ROCKET PHARMACUETICALS INCCOM77313F10650,9652,239,241SH SOLE 2,239,24100
SC HEALTH CORP UNIT 99/99/9999G7851630210,3601,000,000SH SOLE 1,000,00000
SELECT INTERIOR CONCEPTS INC COM816120307945105,105SH SOLE 105,10500
SHOCKWAVE MED INC COM82489T1041,31830,000SH SOLE 30,00000
SIERRA ONCOLOGY INC COM82640U1079102,666,190SH SOLE 2,666,19000
SOLID BIOSCIENCES INC COM3422E105530,0366,749,803SH SOLE 6,749,80300
SPDR SERIES TRUSTS&P BIOTECH 78464A8701,5581,000,000SHPutSOLE 1,000,00000
SPRINGWORKS THERAPEUTICS INC COM85205L107128,4613,337,522SH SOLE 3,337,52200
STOKE THERAPEUTICS INCCOM86150R10719,030671,978SH SOLE 671,97800
TANDEM DIABETES CARE INC COM87537220318,479310,000SH SOLE 310,00000
THERAPEUTICSMD INC COM88338N1072,6531,096,101SH SOLE 1,096,10100
TRANSLATE BIO INC COM89374L1043,541435,000SH SOLE 435,00000
TURNING POINT THERAPEUTICS ICOM90041T10827,245437,390SH SOLE 437,39000
TWIST BIOSCIENCE CORPCOM90184D1004,533215,856SH SOLE 215,85600
UROVANT SCIENCES LTD COMG9381B10837,3312,406,931SH SOLE 2,406,93100
VAPOTHERM INC COM92210710721,2041,743,767SH SOLE 1,743,76700
VBI VACCINES INC COM91822J10363,41345,951,556SH SOLE 45,951,55600
VERRICA PHARMACEUTICALS INC COM92511W10852,0223,410,412SH SOLE 3,410,41200
VERU INC COM92536C1035,5281,650,000SH SOLE 1,650,00000
VIEWRAY INC COM92672L10710,3462,451,748SH SOLE 2,451,74800
VOCERA COMMUNICATIONS INC COM92857F1076,154296,420SH SOLE 296,42000
Y-MABS THERAPEUTICS INC COM98424110917,570562,237SH SOLE 562,23700
ZIMMER BIOMET HLDGS INCCOM98956P1027,48450,000SH SOLE 50,00000
ZOGENIX INC COM98978L204193,3583,709,152SH SOLE 3,709,15200
ZYMEWORKS INC COM98985W102109,2412,403,026SH SOLE 2,403,02600
ZYNERBA PHARMACEUTICALS INC COM98986X109790200,000SHPutSOLE 200,00000