The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 11,088 220,000 SH   SOLE   220,000 0 0
ABEONA THERAPEUTICS INC W EXP 12/24/201 00289Y115 145 659,636 SH   SOLE   659,636 0 0
ACASTI PHARMA INC CL A NEW 00430K402 3,364 1,779,882 SH   SOLE   1,779,882 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 9,116 295,000 SH   SOLE   295,000 0 0
ADMA BIOLOGICS INC COM 000899104 51,268 11,521,102 SH   SOLE   11,521,102 0 0
AGILE THERAPEUTICS INC COM 00847L100 12,711 10,726,750 SH   SOLE   10,726,750 0 0
ALBIREO PHARMA INC COM 01345P106 34,087 1,704,330 SH   SOLE   1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 16,260 3,085,458 SH   SOLE   3,085,458 0 0
ALECTOR INC COM 014442107 7,379 511,731 SH   SOLE   511,731 0 0
ALLAKOS INC COM 01671P100 507 6,444 SH   SOLE   6,444 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 521 132,300 SH   SOLE   132,300 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 42,075 1,543,790 SH   SOLE   1,543,790 0 0
ALPHATEC HOLDINGS INC COM NEW 02081G201 4,267 850,000 SH   SOLE   850,000 0 0
AMARIN CORPORATION PLC SPONS ADR NEW 023111206 115,763 7,636,079 SH   SOLE   7,636,079 0 0
AMICUS THERAPEUTICS INC COM 03152W109 197,369 24,609,700 SH   SOLE   24,609,700 0 0
AQUESTIVE THERAPEUTICS INC COM 3843E1047 6,720 2,113,400 SH   SOLE   2,113,400 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 43,624 953,129 SH   SOLE   953,129 0 0
ARQULE INC COM 4269E1073 391 54,500 SH   SOLE   54,500 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 866 30,738 SH   SOLE   30,738 0 0
ATHENEX INC COM 04685N103 130,594 10,735,245 SH   SOLE   10,735,245 0 0
AXSOME THERAPEUTICS INC COM 05464T104 1,091 53,879 SH   SOLE   53,879 0 0
BEIGENE LTD SPONSORED ADR 07725L102 2,698 400,000 SH Put SOLE   400,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 750 200,000 SH Put SOLE   200,000 0 0
BIO-RAD LABORATORIES INC SHS-A- COM 090572207 21,628 65,000 SH   SOLE   65,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 64,893 883,264 SH   SOLE   883,264 0 0
BRIDGEBIO PHARMA INC COM 10806X102 143,983 6,706,268 SH   SOLE   6,706,268 0 0
CERNER CORP COM 156782104 4,431 65,000 SH   SOLE   65,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 12,904 2,194,641 SH   SOLE   2,194,641 0 0
CONFORMIS INC COM 20717E101 93 50,000 SH   SOLE   50,000 0 0
CORREVIO PHARMA CORP COM 22026V105 2,000 1,000,000 SH   SOLE   1,000,000 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 38,922 2,587,953 SH   SOLE   2,587,953 0 0
CRYOLIFE INC COM 228903100 1,358 50,000 SH   SOLE   50,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 7,784 1,520,355 SH   SOLE   1,520,355 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 24,014 3,253,923 SH   SOLE   3,253,923 0 0
DBV TECHNOLOGIES SA SPONSORED ADR 23306J101 31,038 3,609,084 SH   SOLE   3,609,084 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 103,658 3,708,705 SH   SOLE   3,708,705 0 0
EHEALTH INC COM 28238P109 17,037 255,089 SH   SOLE   255,089 0 0
EIDOS THERAPEUTICS INC COM 28249H104 24,711 686,992 SH   SOLE   686,992 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,433 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HOLDINGS INC COM G31249108 23,836 1,260,528 SH   SOLE   1,260,528 0 0
FERRARI N.V. COM N3167Y103 955 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31739102 802 62,000 SH   SOLE   62,000 0 0
FOAMIX PHARMACEUTICALS LTD COM M46135105 34,060 11,203,881 SH   SOLE   11,203,881 0 0
FULCRUM THERAPEUTICS INC COM 359616109 3,984 600,000 SH   SOLE   600,000 0 0
G1 THERAPEUTICS INC COM 3621LQ109 358 15,702 SH   SOLE   15,702 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 285,090 5,875,726 SH   SOLE   5,875,726 0 0
HEALTH CATALYST INC COM 42225T107 6,674 210,924 SH   SOLE   210,924 0 0
HEALTH SCIENCES ACQUISITIONS CORP UNIT 04/01/2024 42227C201 4,292 400,000 SH   SOLE   400,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 9,584 1,141,484 SH   SOLE   1,141,484 0 0
INTERCEPT PHARMACEUTICALS INC COM 45845P108 6,477 97,600 SH   SOLE   97,600 0 0
INVITAE CORP COM 46185L103 23,088 1,198,182 SH   SOLE   1,198,182 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 200,467 11,014,702 SH   SOLE   11,014,702 0 0
KADMON HOLDINGS INC COM 48283N106 33,177 13,165,746 SH   SOLE   13,165,746 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 526 54,645 SH   SOLE   54,645 0 0
KODIAK SCIENCES INC COM 50015M109 45,084 3,135,199 SH   SOLE   3,135,199 0 0
MARKER THERAPEUTICS INC COM 57055L107 10,220 2,000,000 SH   SOLE   2,000,000 0 0
MEDICINES CO COM 584688105 977 19,532 SH   SOLE   19,532 0 0
MEDPACE HLDGS INC COM 58506Q109 532 6,328 SH   SOLE   6,328 0 0
MEI PHARMA INC COM NEW 55279B202 7,392 4,400,440 SH   SOLE   4,400,440 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 102,610 6,433,277 SH   SOLE   6,433,277 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 534 179,419 SH   SOLE   179,419 0 0
MERIT MEDICAL SYSTEMS INC COM 589889104 16,107 528,788 SH   SOLE   528,788 0 0
MIRATI THERAPEUTICS INC COM 60468T105 145 100,000 SH Put SOLE   100,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 258,241 3,314,606 SH   SOLE   3,314,606 0 0
MOLECULAR TEMPLATES INC COM 608550109 13,010 1,974,133 SH   SOLE   1,974,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 37,649 2,905,000 SH   SOLE   2,905,000 0 0
MORPHIC HOLDING INC COM 61775R105 11,772 650,000 SH   SOLE   650,000 0 0
MOTUS GI HLDGS INC COM 62014P108 8,336 4,210,542 SH   SOLE   4,210,542 0 0
MYOKARDIA INC COM 62857M105 58,956 1,130,511 SH   SOLE   1,130,511 0 0
NATERA INC COM 632307104 477 14,549 SH   SOLE   14,549 0 0
NEPTUNE WELLNESS SOLUTIONS INC COM 64079L105 47,835 13,436,906 SH   SOLE   13,436,906 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 365,837 4,059,900 SH   SOLE   4,059,900 0 0
NEVRO CORP COM 64157F103 83,801 974,773 SH   SOLE   974,773 0 0
NOVOCURE LTD ORD SHS G6674U108 710 9,489 SH   SOLE   9,489 0 0
ORCHARD THERAPETICS PLC ADS 68570P101 6,198 521,800 SH   SOLE   521,800 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 48 420,875 SH   SOLE   420,875 0 0
PROTAGONIST THERAPEUTICS INC COM 4366E1029 24,876 2,071,297 SH   SOLE   2,071,297 0 0
PROVENTION BIO INC COM 74374N102 4,548 666,322 SH   SOLE   666,322 0 0
QUOTIENT LTD SHS G73268107 83,830 10,789,054 SH   SOLE   10,789,054 0 0
RA PHARMACEUTICALS INC COM 74933V108 342 14,455 SH   SOLE   14,455 0 0
REGENXBIO INC COM 75901B107 21,645 608,000 SH   SOLE   608,000 0 0
RETROPHIN INC COM 761299106 37,905 3,270,571 SH   SOLE   3,270,571 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 23,037 1,977,412 SH   SOLE   1,977,412 0 0
SC HEALTH CORP UNIT 99/99/9999 G78516302 10,350 1,000,000 SH   SOLE   1,000,000 0 0
SEATTLE GENETICS INC COM 812578102 1,452 17,000 SH   SOLE   17,000 0 0
SELECT INTERIOR CONCEPTS INC CL A 816120307 5,707 440,000 SH   SOLE   440,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 1,041 2,666,190 SH   SOLE   2,666,190 0 0
SOLID BIOSCIENCES INC COM 83422E105 69,792 6,749,803 SH   SOLE   6,749,803 0 0
SPARK THERAPEUTICS INC COM 84652J103 33,943 350,000 SH   SOLE   350,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 1,604 900,000 SH Put SOLE   900,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 69,755 3,217,522 SH   SOLE   3,217,522 0 0
STOKE THERAPEUTICS DEAL SHARES COM 86150R107 14,440 671,978 SH   SOLE   671,978 0 0
TANDEM DIABETES CARE INC COM 875372203 379 6,422 SH   SOLE   6,422 0 0
TELADOC HEALTH INC NOTE 1.375% 5/1 87918AAC9 7,398 5,000,000 PRN   SOLE   5,000,000 0 0
TRANSLATE BIO INC COM 89374L104 4,311 435,000 SH   SOLE   435,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 22,454 597,190 SH   SOLE   597,190 0 0
TWIST BIOSCIENCE CORP COM 90184D100 3,483 145,856 SH   SOLE   145,856 0 0
UROVANT SCIENCES LTD COM G9381B108 21,275 2,246,547 SH   SOLE   2,246,547 0 0
VAPOTHERM INC COM 922107107 16,709 1,764,470 SH   SOLE   1,764,470 0 0
VBI VACCINES INC COM 91822J103 45,951 45,951,556 SH   SOLE   45,951,556 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 50,337 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 3,564 1,650,000 SH   SOLE   1,650,000 0 0
VIEWRAY INC COM 92672L107 7,110 2,451,748 SH   SOLE   2,451,748 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 2,460 99,804 SH   SOLE   99,804 0 0
Y-MABS THERAPEUTICS INC COM 984241109 22,280 854,940 SH   SOLE   854,940 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 6,864 50,000 SH   SOLE   50,000 0 0
ZOGENIX INC COM 98978L204 130,696 3,264,152 SH   SOLE   3,264,152 0 0
ZYMEWORKS INC COM 98985W102 59,244 2,388,890 SH   SOLE   2,388,890 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 635 200,000 SH Put SOLE   200,000 0 0