The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
10X GENOMICS INC CL A COM88025U10911,088220,000SH SOLE 220,00000
ABEONA THERAPEUTICS INCW EXP 12/24/20100289Y115145659,636SH SOLE 659,63600
ACASTI PHARMA INC CL A NEW 00430K4023,3641,779,882SH SOLE 1,779,88200
ADAPTIVE BIOTECHNOLOGIES CORCOM00650F1099,116295,000SH SOLE 295,00000
ADMA BIOLOGICS INCCOM00089910451,26811,521,102SH SOLE 11,521,10200
AGILE THERAPEUTICS INC COM00847L10012,71110,726,750SH SOLE 10,726,75000
ALBIREO PHARMA INC COM01345P10634,0871,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INCCOM01438T10616,2603,085,458SH SOLE 3,085,45800
ALECTOR INC COM0144421077,379511,731SH SOLE 511,73100
ALLAKOS INC COM01671P1005076,444SH SOLE 6,44400
ALLENA PHARMACEUTICALS INC COM018119107521132,300SH SOLE 132,30000
ALLOGENE THERAPEUTICS INC COM01977010642,0751,543,790SH SOLE 1,543,79000
ALPHATEC HOLDINGS INC COM NEW02081G2014,267850,000SH SOLE 850,00000
AMARIN CORPORATION PLC SPONS ADR NEW 023111206115,7637,636,079SH SOLE 7,636,07900
AMICUS THERAPEUTICS INC COM03152W109197,36924,609,700SH SOLE 24,609,70000
AQUESTIVE THERAPEUTICS INC COM3843E10476,7202,113,400SH SOLE 2,113,40000
ARENA PHARMACEUTICALS INCCOM NEW 04004760743,624953,129SH SOLE 953,12900
ARQULE INC COM4269E107339154,500SH SOLE 54,50000
ARROWHEAD PHARMACEUTICALS INC COM04280A10086630,738SH SOLE 30,73800
ATHENEX INC COM04685N103130,59410,735,245SH SOLE 10,735,24500
AXSOME THERAPEUTICS INC COM05464T1041,09153,879SH SOLE 53,87900
BEIGENE LTD SPONSORED ADR07725L1022,698400,000SHPutSOLE 400,00000
BIOMARIN PHARMACEUTICAL INC COM09061G101750200,000SHPutSOLE 200,00000
BIO-RAD LABORATORIES INC SHS-A-COM09057220721,62865,000SH SOLE 65,00000
BLUEPRINT MEDICINES CORP COM09627Y10964,893883,264SH SOLE 883,26400
BRIDGEBIO PHARMA INC COM10806X102143,9836,706,268SH SOLE 6,706,26800
CERNER CORP COM1567821044,43165,000SH SOLE 65,00000
CONCERT PHARMACEUTICALS INC COM20602210512,9042,194,641SH SOLE 2,194,64100
CONFORMIS INC COM20717E1019350,000SH SOLE 50,00000
CORREVIO PHARMA CORP COM22026V1052,0001,000,000SH SOLE 1,000,00000
CRINETICS PHARMACEUTICALS INC COM22663K10738,9222,587,953SH SOLE 2,587,95300
CRYOLIFE INC COM2289031001,35850,000SH SOLE 50,00000
CYMABAY THERAPEUTICS INCCOM23257D1037,7841,520,355SH SOLE 1,520,35500
CYTOMX THERAPEUTICS INC COM23284F10524,0143,253,923SH SOLE 3,253,92300
DBV TECHNOLOGIES SA SPONSORED ADR23306J10131,0383,609,084SH SOLE 3,609,08400
DOVA PHARMACEUTICALS INC COM25985T102103,6583,708,705SH SOLE 3,708,70500
EHEALTH INC COM28238P10917,037255,089SH SOLE 255,08900
EIDOS THERAPEUTICS INCCOM28249H10424,711686,992SH SOLE 686,99200
EIGER BIOPHARMACEUTICALS INC COM28249U1051,433139,890SH SOLE 139,89000
ESTABLISHMENT LABS HOLDINGS INC COMG3124910823,8361,260,528SH SOLE 1,260,52800
FERRARI N.V. COMN3167Y1039556,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES N SHSN3173910280262,000SH SOLE 62,00000
FOAMIX PHARMACEUTICALS LTD COMM4613510534,06011,203,881SH SOLE 11,203,88100
FULCRUM THERAPEUTICS INCCOM3596161093,984600,000SH SOLE 600,00000
G1 THERAPEUTICS INCCOM3621LQ10935815,702SH SOLE 15,70200
GLOBAL BLOOD THERAPEUTICS INCCOM37890U108285,0905,875,726SH SOLE 5,875,72600
HEALTH CATALYST INC COM42225T1076,674210,924SH SOLE 210,92400
HEALTH SCIENCES ACQUISITIONS CORPUNIT 04/01/202442227C2014,292400,000SH SOLE 400,00000
IDEAYA BIOSCIENCES INC COM45166A1029,5841,141,484SH SOLE 1,141,48400
INTERCEPT PHARMACEUTICALS INC COM45845P1086,47797,600SH SOLE 97,60000
INVITAE CORPCOM46185L10323,0881,198,182SH SOLE 1,198,18200
IOVANCE BIOTHERAPEUTICS INC COM462260100200,46711,014,702SH SOLE 11,014,70200
KADMON HOLDINGS INC COM48283N10633,17713,165,746SH SOLE 13,165,74600
KARYOPHARM THERAPEUTICS INC COM48576U10652654,645SH SOLE 54,64500
KODIAK SCIENCES INC COM50015M10945,0843,135,199SH SOLE 3,135,19900
MARKER THERAPEUTICS INCCOM57055L10710,2202,000,000SH SOLE 2,000,00000
MEDICINES CO COM58468810597719,532SH SOLE 19,53200
MEDPACE HLDGS INCCOM58506Q1095326,328SH SOLE 6,32800
MEI PHARMA INC COM NEW55279B2027,3924,400,440SH SOLE 4,400,44000
MEIRAGTX HOLDINGS PLC COMG59665102102,6106,433,277SH SOLE 6,433,27700
MEREO BIOPHARMA GROUP PLCADS589492107534179,419SH SOLE 179,41900
MERIT MEDICAL SYSTEMS INC COM58988910416,107528,788SH SOLE 528,78800
MIRATI THERAPEUTICS INC COM60468T105145100,000SHPutSOLE 100,00000
MIRATI THERAPEUTICS INCCOM60468T105258,2413,314,606SH SOLE 3,314,60600
MOLECULAR TEMPLATES INC COM60855010913,0101,974,133SH SOLE 1,974,13300
MOMENTA PHARMACEUTICALS INC COM60877T10037,6492,905,000SH SOLE 2,905,00000
MORPHIC HOLDING INC COM61775R10511,772650,000SH SOLE 650,00000
MOTUS GI HLDGS INCCOM62014P1088,3364,210,542SH SOLE 4,210,54200
MYOKARDIA INCCOM62857M10558,9561,130,511SH SOLE 1,130,51100
NATERA INC COM63230710447714,549SH SOLE 14,54900
NEPTUNE WELLNESS SOLUTIONS INC COM64079L10547,83513,436,906SH SOLE 13,436,90600
NEUROCRINE BIOSCIENCES INC COM64125C109365,8374,059,900SH SOLE 4,059,90000
NEVRO CORP COM64157F10383,801974,773SH SOLE 974,77300
NOVOCURE LTDORD SHSG6674U1087109,489SH SOLE 9,48900
ORCHARD THERAPETICS PLCADS68570P1016,198521,800SH SOLE 521,80000
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20269012T11548420,875SH SOLE 420,87500
PROTAGONIST THERAPEUTICS INC COM4366E102924,8762,071,297SH SOLE 2,071,29700
PROVENTION BIO INC COM74374N1024,548666,322SH SOLE 666,32200
QUOTIENT LTD SHSG7326810783,83010,789,054SH SOLE 10,789,05400
RA PHARMACEUTICALS INCCOM74933V10834214,455SH SOLE 14,45500
REGENXBIO INC COM75901B10721,645608,000SH SOLE 608,00000
RETROPHIN INC COM76129910637,9053,270,571SH SOLE 3,270,57100
ROCKET PHARMACEUTICALS INC COM77313F10623,0371,977,412SH SOLE 1,977,41200
SC HEALTH CORP UNIT 99/99/9999G7851630210,3501,000,000SH SOLE 1,000,00000
SEATTLE GENETICS INCCOM8125781021,45217,000SH SOLE 17,00000
SELECT INTERIOR CONCEPTS INC CL A8161203075,707440,000SH SOLE 440,00000
SIERRA ONCOLOGY INC COM82640U1071,0412,666,190SH SOLE 2,666,19000
SOLID BIOSCIENCES INC COM83422E10569,7926,749,803SH SOLE 6,749,80300
SPARK THERAPEUTICS INC COM84652J10333,943350,000SH SOLE 350,00000
SPDR SERIES TRUST S&P BIOTECH 78464A8701,604900,000SHPutSOLE 900,00000
SPRINGWORKS THERAPEUTICS INCCOM85205L10769,7553,217,522SH SOLE 3,217,52200
STOKE THERAPEUTICS DEAL SHARES COM86150R10714,440671,978SH SOLE 671,97800
TANDEM DIABETES CARE INC COM8753722033796,422SH SOLE 6,42200
TELADOC HEALTH INCNOTE 1.375% 5/187918AAC97,3985,000,000PRN SOLE 5,000,00000
TRANSLATE BIO INC COM89374L1044,311435,000SH SOLE 435,00000
TURNING POINT THERAPEUTICS ICOM90041T10822,454597,190SH SOLE 597,19000
TWIST BIOSCIENCE CORPCOM90184D1003,483145,856SH SOLE 145,85600
UROVANT SCIENCES LTD COMG9381B10821,2752,246,547SH SOLE 2,246,54700
VAPOTHERM INC COM92210710716,7091,764,470SH SOLE 1,764,47000
VBI VACCINES INC COM91822J10345,95145,951,556SH SOLE 45,951,55600
VERRICA PHARMACEUTICALS INC COM92511W10850,3373,410,412SH SOLE 3,410,41200
VERU INC COM92536C1033,5641,650,000SH SOLE 1,650,00000
VIEWRAY INC COM92672L1077,1102,451,748SH SOLE 2,451,74800
VOCERA COMMUNICATIONS INC COM92857F1072,46099,804SH SOLE 99,80400
Y-MABS THERAPEUTICS INCCOM98424110922,280854,940SH SOLE 854,94000
ZIMMER BIOMET HLDGS INC COM98956P1026,86450,000SH SOLE 50,00000
ZOGENIX INC COM98978L204130,6963,264,152SH SOLE 3,264,15200
ZYMEWORKS INC COM98985W10259,2442,388,890SH SOLE 2,388,89000
ZYNERBA PHARMACEUTICALS INC COM98986X109635200,000SHPutSOLE 200,00000