The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INC*W EXP 12/24/20100289Y115620659,636SH SOLE 659,63600
ACASTI PHARMA INC CL A NEW 00430K4022,0291,779,882SH SOLE 1,779,88200
ACORDA THERAPEUTICS INC COM00484M1068,6471,127,318SH SOLE 1,127,31800
ADAPTIVE BIOTECHNOLOGIES CORCOM00650F10913,766285,000SH SOLE 285,00000
ADMA BIOLOGICS INCCOM00089910444,58611,521,102SH SOLE 11,521,10200
AGILE THERAPEUTICS INCCOM00847L10010,4438,426,750SH SOLE 8,426,75000
ALBIREO PHARMA INC COM01345P10654,9481,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INCCOM01438T10618,5123,085,458SH SOLE 3,085,45800
ALECTOR INC COM0144421079,325511,731SH SOLE 511,73100
ALLENA PHARMACEUTICALS INC COM018119107538132,300SH SOLE 132,30000
ALLOGENE THERAPEUTICS INC COM01977010641,4501,543,790SH SOLE 1,543,79000
AMARIN CORPORATION PLC SPONS ADR NEW 023111206120,2426,201,269SH SOLE 6,201,26900
AMICUS THERAPEUTICS INC COM03152W109268,43821,509,486SH SOLE 21,509,48600
ANI PHARMACEUTICALS INCNOTE 3.000% 12/000182CAA18,9927,500,000PRN SOLE 7,500,00000
AQUESTIVE THERAPEUTICS INC COM3843E10478,8762,113,400SH SOLE 2,113,40000
ARENA PHARMACEUTICALS INCCOM NEW 04004760780,9191,380,171SH SOLE 1,380,17100
ARRAY BIOPHARMA INC COM04269X10548,1091,038,390SH SOLE 1,038,39000
ARROWHEAD PHARMACEUTICALS INC COM04280A1008,765330,738SH SOLE 330,73800
ASCENDIS PHARMA A SSPONSORED ADR04351P10154,521473,475SH SOLE 473,47500
ATHENEX INC COM04685N103187,6369,822,118SH SOLE 9,822,11800
AXONICS MODULATION TECHNOLOGIES INC COM05465P10111,697285,502SH SOLE 285,50200
AXSOME THERAPEUTICS INC COM05464T1041,38753,879SH SOLE 53,87900
BAUSCH HEALTH COS INCCOM07173410715,132600,000SH SOLE 600,00000
BIOGEN INC COM09062X10365200,000SHCallSOLE 200,00000
BLUEPRINT MEDICINES CORP COM09627Y109114,3971,212,731SH SOLE 1,212,73100
BRIDGEBIO PHARMA INCCOM10806X102180,8686,706,268SH SOLE 6,706,26800
CONCERT PHARMACEUTICALS INC COM20602210526,4562,204,641SH SOLE 2,204,64100
CONFORMIS INC COM0717E1010436100,000SH SOLE 100,00000
CRINETICS PHARMACEUTICALS INC COM22663K10764,6982,587,953SH SOLE 2,587,95300
CRYOLIFE INC COM2289031001,49750,000SH SOLE 50,00000
CYMABAY THERAPEUTICS INC COM23257D10327,6573,862,821SH SOLE 3,862,82100
CYTOMX THERAPEUTICS INC COM23284F10535,3873,153,923SH SOLE 3,153,92300
DBV TECHNOLOGIES S A SPONSORED ADR23306J10129,6663,609,084SH SOLE 3,609,08400
DEXCOM INC COM2521311078,99060,000SH SOLE 60,00000
DOVA PHARMACEUTICALS INC COM25985T10250,0983,553,060SH SOLE 3,553,06000
EHEALTH INC COM28238P10933,233385,982SH SOLE 385,98200
EIDOS THERAPEUTICS INCCOM28249H10421,349686,992SH SOLE 686,99200
EIGER BIOPHARMACEUTICALS INC COM28249U1051,482139,890SH SOLE 139,89000
ESTABLISHMENT LABS HLDGS INC COMG3124910827,7191,260,528SH SOLE 1,260,52800
FERRARI N.V.COMN3167Y1031,0016,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES NSHSN3173910210,00862,000SH SOLE 62,00000
FLUIDIGM CORP COM34385P10856746,030SH SOLE 46,03000
FOAMIX PHARMACEUTICALS LTD SHSM4613510511,0954,661,824SH SOLE 4,661,82400
GLOBAL BLOOD THERAPEUTICS INC COM37890U108303,8035,775,726SH SOLE 5,775,72600
GUARDANT HEALTH INC COM40131M1095716,617SH SOLE 6,61700
HEALTH SCIENCES ACQUISITIONS CORPUNIT 04/01/202442227C2014,241400,000SH SOLE 400,00000
IDEAYA BIOSCIENCES INC COM45166A10211,3691,141,484SH SOLE 1,141,48400
INTERCEPT PHARMACEUTICALS INC COM45845P1087,76697,600SH SOLE 97,60000
INVITAE CORP COM46185L10331,5721,343,491SH SOLE 1,343,49100
IOVANCE BIOTHERAPEUTICS INC COM462260100292,15811,915,127SH SOLE 11,915,12700
KADMON HOLDINGS INC COM48283N10627,12113,165,746SH SOLE 13,165,74600
KODIAK SCIENCES INC COM50015M10936,6813,135,199SH SOLE 3,135,19900
MARKER THERAPEUTICS INCCOM57055L10715,8402,000,000SH SOLE 2,000,00000
MEDICINES CO COM58468810571219,532SH SOLE 19,53200
MEI PHARMA INC COM NEW 55279B20211,0014,400,440SH SOLE 4,400,44000
MEIRAGTX HOLDINGS PLC COMG59665102155,7666,007,746SH SOLE 6,007,74600
MEREO BIOPHARMA GROUP PLCADS589492107452179,419SH SOLE 179,41900
MERIT MEDICAL SYSTEMS INC COM58988910448,673817,209SH SOLE 817,20900
MIRATI THERAPEUTICS INC COM60468T105298,6592,899,606SH SOLE 2,899,60600
MOLECULAR TEMPLATES INC COM60855010916,4841,974,133SH SOLE 1,974,13300
MOMENTA PHARMACEUTICALS INC COM60877T10036,1672,905,000SH SOLE 2,905,00000
MORPHIC HOLDING INC COM61775R10512,883650,000SH SOLE 650,00000
MOTUS GI HLDGS INC COM62014P10812,7574,210,542SH SOLE 4,210,54200
MYOKARDIA INC COM62857M10555,1801,100,511SH SOLE 1,100,51100
NATERA INC COM63230710440114,549SH SOLE 14,54900
NEPTUNE WELLNESS SOLUTIONS INC COM64079L10529,9788,891,452SH SOLE 8,891,45200
NEUROCRINE BIOSCIENCES INC COM64125C109339,7344,023,862SH SOLE 4,023,86200
NEVRO CORP COM64157F10373,7611,137,765SH SOLE 1,137,76500
ORCHARD THERAPEUTICS PLCADS68570P1017,299521,800SH SOLE 521,80000
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20269012T11546420,875SH SOLE 420,87500
PROTAGONIST THERAPEUTICS INC COM4366E102925,0832,071,297SH SOLE 2,071,29700
QUOTIENT LTD SHSG73268107100,87710,789,054SH SOLE 10,789,05400
REGENXBIO INC COM75901B10749,880970,997SH SOLE 970,99700
RETROPHIN INC COM76129910675,7913,772,582SH SOLE 3,772,58200
RHYTHM PHARMACEUTICALS INC COM76243J1055,785262,970SH SOLE 262,97000
ROCKET PHARMACEUTICALS INC COM77313F10629,6611,977,412SH SOLE 1,977,41200
ROCKWELL MEDICAL INC COM7743741024,5151,500,000SH SOLE 1,500,00000
SERES THERAPEUTICS INC COM81750R1028,0502,500,000SH SOLE 2,500,00000
SHOCKWAVE MEDICAL INC COM82489T1048,564150,000SH SOLE 150,00000
SIERRA ONCOLOGY INC COM82640U1071,4932,666,190SH SOLE 2,666,19000
SOLID BIOSCIENCES INC COM83422E10523200SHCallSOLE 20000
SOLID BIOSCIENCES INC COM83422E10522,5813,927,222SH SOLE 3,927,22200
SPARK THERAPEUTICS INC COM84652J10335,833350,000SH SOLE 350,00000
SPDR SERIES TRUSTS&P BIOTECH 78464A87070200,000SHPutSOLE 200,00000
STOKE THERAPEUTICS INC COM86150R10719,601671,978SH SOLE 671,97800
SYNLOGIC INC COM87166L1007,897867,852SH SOLE 867,85200
TANDEM DIABETES CARE INC COM8753722034146,422SH SOLE 6,42200
TELADOC HEALTH INCCOM87918A10520,389307,021SH SOLE 307,02100
TENET HEALTHCARE CORP COM88033G4076,211300,633SH SOLE 300,63300
TRANSLATE BIO INC COM89374L1045,494435,000SH SOLE 435,00000
TURNING POINT THERAPEUTICS ICOM90041T10817,296424,968SH SOLE 424,96800
TWIST BIOSCIENCE CORPCOM90184D1003,216110,856SH SOLE 110,85600
UNIQURE N.VCOMN9006410122,024281,820SH SOLE 281,82000
UROVANT SCIENCES LTD COMG9381B10814,8351,875,426SH SOLE 1,875,42600
VAPOTHERM INC COM92210710732,3021,404,470SH SOLE 1,404,47000
VBI VACCINES INC COM91822J10324,60725,951,556SH SOLE 25,951,55600
VERRICA PHARMACEUTICALS INC COM92511W10839,6283,410,412SH SOLE 3,410,41200
VERU INC COM92536C1033,0781,445,000SH SOLE 1,445,00000
VIEWRAY INC COM92672L10748,0615,455,243SH SOLE 5,455,24300
VOCERA COMMUNICATIONS INC COM92857F1076,205194,400SH SOLE 194,40000
VOYAGER THERAPEUTICS INC COM92915B10699636,573SH SOLE 36,57300
ZIOPHARM ONCOLOGY INC COM98973P10152890,498SH SOLE 90,49800
ZOGENIX INC COM98978L204167,5753,507,223SH SOLE 3,507,22300
ZYMEWORKS INC COM98985W10252,1152,368,890SH SOLE 2,368,89000