The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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OMB Number:3235-0006
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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INC *W EXP 12/24/20100289Y1151,906659,636SH SOLE 659,63600
ABEONA THERAPEUTICS INC COM00289Y1071,331180,797SH SOLE 180,79700
ACADIA PHARMACEUTICALS INC COM00422510840014,897SH SOLE 14,89700
ACASTI PHARMA INC CL A NEW 00430K4021,8151,779,882SH SOLE 1,779,88200
ADMA BIOLOGICS INC COM00089910424,7156,521,102SH SOLE 6,521,10200
AGILE THERAPEUTICS INCCOM00847L10012,7248,426,750SH SOLE 8,426,75000
AGIOS PHARMACEUTICALS INC COM00847X104140200,000SHCallSOLE 200,00000
AKEBIA THERAPEUTICS INC COM00972D10513,9511,703,440SH SOLE 1,703,44000
ALBIREO PHARMA INC COM01345P10654,8961,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INC COM01438T10627,8623,085,458SH SOLE 3,085,45800
ALECTOR INC COM0144421079,579511,731SH SOLE 511,73100
ALLENA PHARMACEUTICALS INC COM018119107929132,300SH SOLE 132,30000
ALLOGENE THERAPEUTICS INC COM01977010644,6301,543,790SH SOLE 1,543,79000
AMARIN CORPORATION PLC SPONS ADR NEW023111206135,7906,540,957SH SOLE 6,540,95700
AMICUS THERAPEUTICS INC COM03152W109294,29721,639,486SH SOLE 21,639,48600
ANI PHARMACEUTICALS INCNOTE 3.000%12/000182CAA18,2397,500,000PRN SOLE 7,500,00000
AQUESTIVE THERAPEUTICS INC COM3843E104714,6032,113,400SH SOLE 2,113,40000
ARENA PHARMACEUTICALS INC COM04004760762,7701,400,171SH SOLE 1,400,17100
ARRAY BIOPHARMA INC COM04269X105103,1014,228,900SH SOLE 4,228,90000
ARROWHEAD PHARMACEUTICALS INC COM04280A1006,069330,738SH SOLE 330,73800
ASCENDIS PHARMA A SCOM04351P10125200,000SHPutSOLE 200,00000
ASCENDIS PHARMA A SSPONSORED ADR04351P101131,0391,113,328SH SOLE 1,113,32800
ATHENEX INC COM04685N10362,4265,096,022SH SOLE 5,096,02200
AVEDRO INC COM05355N1091,227100,000SH SOLE 100,00000
AXONICS MODULATION TECHNOLOGIES INC COM05465P10116,424685,756SH SOLE 685,75600
AXSOME THERAPEUTICS INC COM05464T10476753,879SH SOLE 53,87900
BAUSCH HEALTH COS INC COM07173410714,820600,000SH SOLE 600,00000
BIOGEN INC COM09062X103620400,000SHCallSOLE 400,00000
BIOTELEMETRY INC COM0906721063996,369SH SOLE 6,36900
BLUEPRINT MEDICINES CORP COM09627Y109101,7481,271,054SH SOLE 1,271,05400
CLOVIS ONCOLOGY INC COM189464100125200,000SHCallSOLE 200,00000
CLOVIS ONCOLOGY INC COM189464100660200,000SHPutSOLE 200,00000
CONCERT PHARMACEUTICALS INC COM20602210526,6102,204,641SH SOLE 2,204,64100
CRINETICS PHARMACEUTICALS INC COM22663K10758,9012,587,953SH SOLE 2,587,95300
CRYOLIFE INC COM2289031001,45950,000SH SOLE 50,00000
CYMABAY THERAPEUTICS INC COM23257D10355,9464,212,821SH SOLE 4,212,82100
CYTOMX THERAPEUTICS INC COM23284F10534,1203,173,923SH SOLE 3,173,92300
DBV TECHNOLOGIES S A SPONSORED ADR23306J1018,7001,128,524SH SOLE 1,128,52400
DOVA PHARMACEUTICALS INC COM25985T10227,7883,125,851SH SOLE 3,125,85100
EHEALTH INC COM28238P10918,070289,857SH SOLE 289,85700
EIDOS THERAPEUTICS INCCOM28249H10416,109686,992SH SOLE 686,99200
EIGER BIOPHARMACEUTICALS INC COM28249U1051,955139,890SH SOLE 139,89000
ESTABLISHMENT LABS HLDGS INC COMG3124910814,766614,242SH SOLE 614,24200
EVOLUS INC COM30052C10734415,232SH SOLE 15,23200
FERRARI N.V. COMN3167Y1038306,200SH SOLE 6,20000
FIBROGEN INC COM31572Q8085069,306SH SOLE 9,30600
FIAT CHRYSLER AUTOMOBILES NSHSN3173910292062,000SH SOLE 62,00000
FLUIDIGM CORP COM34385P10861246,030SH SOLE 46,03000
FOAMIX PHARMACEUTICALS LTD SHSM4613510517,4824,661,824SH SOLE 4,661,82400
GLOBAL BLOOD THERAPEUTICS INC COM37890U108292,4765,525,726SH SOLE 5,525,72600
HUMANA INC COM4448591029,31035,000SH SOLE 35,00000
IMMUNOGEN INC COM45253H10115600,000SHCallSOLE 600,00000
IMMUNOMEDICS INCCOM452907108125200,000SHCallSOLE 200,00000
INTERSECT ENT INC COM46071F1032,25170,000SH SOLE 70,00000
INVITAE CORP COM46185L10350,8662,171,918SH SOLE 2,171,91800
IOVANCE BIOTHERAPEUTICS INC COM462260100116,36212,235,811SH SOLE 12,235,81100
IRHYTHM TECHNOLOGIES INC COM45005610614,992200,000SH SOLE 200,00000
KADMON HOLDINGS INC COM48283N10634,75713,165,746SH SOLE 13,165,74600
KODIAK SCIENCES INC COM50015M10920,4723,135,199SH SOLE 3,135,19900
LIVANOVA PLC SHSG5509L1013,89040,000SH SOLE 40,00000
MARKER THERAPEUTICS INCCOM57055L10713,2002,000,000SH SOLE 2,000,00000
MEI PHARMA INCCOM NEW55279B20213,5094,400,440SH SOLE 4,400,44000
MEIRAGTX HOLDINGS PLC COMG59665102103,5136,007,746SH SOLE 6,007,74600
MERIT MEDICAL SYSTEMS INC COM58988910465,1131,053,098SH SOLE 1,053,09800
MIRATI THERAPEUTICS INC COM60468T10585,3491,164,382SH SOLE 1,164,38200
MOLECULAR TEMPLATES INC COM60855010911,4701,974,133SH SOLE 1,974,13300
MOMENTA PHARMACEUTICALS INC COM60877T10041,7742,875,000SH SOLE 2,875,00000
MOTUS GI HLDGS INCCOM62014P10812,5213,210,542SH SOLE 3,210,54200
MYOKARDIA INCCOM62857M10551,393988,511SH SOLE 988,51100
NEPTUNE WELLNESS SOLUTIONS INC COM64079L10528,3638,891,452SH SOLE 8,891,45200
NEUROCRINE BIOSCIENCES INC COM64125C109331,1383,758,662SH SOLE 3,758,66200
NEVRO CORP COM64157F10326,063416,949SH SOLE 416,94900
ONCOMED PHARMACEUTICALS INC COM68234X1021,7871,719,111SH SOLE 1,719,11100
ONCOSEC MEDICAL INC COM68234L2071730,000SH SOLE 30,00000
ORCHARD THERAPEUTICS PLC ADS68570P1019,329521,800SH SOLE 521,80000
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20269012T115159420,875SH SOLE 420,87500
PROQR THERAPEUTICS N.V. SHS EURON7154210910,021722,523SH SOLE 722,52300
PROTAGONIST THERAPEUTICS INC COM4366E102926,0362,071,297SH SOLE 2,071,29700
QUOTIENT LTDSHSG7326810797,20910,789,054SH SOLE 10,789,05400
REGENXBIO INC COM75901B10765,6621,145,726SH SOLE 1,145,72600
RETROPHIN INC COM76129910669,1283,054,707SH SOLE 3,054,70700
RHYTHM PHARMACEUTICALS INC COM76243J10513,786502,970SH SOLE 502,97000
ROCKET PHARMACEUTICALS INC COM77313F1068,036458,173SH SOLE 458,17300
SAREPTA THERAPEUTICS INC COM803607100421100,000SHCallSOLE 100,00000
SHOCKWAVE MEDICAL INC COM82489T1045,021150,000SH SOLE 150,00000
SIERRA ONCOLOGY INC COM82640U1074,5592,666,190SH SOLE 2,666,19000
SOLID BIOSCIENCES INC COM3422E10552910,000SHCallSOLE 10,00000
SOLID BIOSCIENCES INC COM3422E105536,1303,927,222SH SOLE 3,927,22200
SYNLOGIC INC COM87166L1006,587867,852SH SOLE 867,85200
TANDEM DIABETES CARE INC COM87537220381612,844SH SOLE 12,84400
TELADOC HEALTH INC COM87918A10527,522495,000SH SOLE 495,00000
TRANSLATE BIO INC COM89374L1044,433435,000SH SOLE 435,00000
ULTRAGENYX PHARMACEUTICAL INC COM90400D1083,46850,000SH SOLE 50,00000
UNIQURE NV. SHSN9006410113,828231,820SH SOLE 231,82000
UROVANT SCIENCES LTD COMG9381B1088,697865,359SH SOLE 865,35900
VAPOTHERM INC COM92210710724,4901,246,315SH SOLE 1,246,31500
VBI VACCINES INC COM91822J10342,63323,951,556SH SOLE 23,951,55600
VERACYTE INC COM92337F10778931,521SH SOLE 31,52100
VERICEL CORP COM92346J10849228,090SH SOLE 28,09000
VERRICA PHARMACEUTICALS INC COM92511W10838,5373,410,412SH SOLE 3,410,41200
VERU INC COM92536C1032,0811,425,000SH SOLE 1,425,00000
VIEWRAY INC COM92672L10735,5144,805,650SH SOLE 4,805,65000
VOCERA COMMUNICATIONS INC COM92857F1071,58250,000SH SOLE 50,00000
ZOGENIX INC COM98978L204212,8603,869,491SH SOLE 3,869,49100
ZYMEWORKS INC COM98985W1028,529573,890SH SOLE 573,89000