The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INC W EXP12/24/20100289Y1151,267659,636SH SOLE 659,63600
ABEONA THERAPEUTICS INCCOM00289Y1071,269180,797SH SOLE 180,79700
ACASTI PHARMA INC CL A NEW 00430K4021,4801,779,882SH SOLE 1,779,88200
ACCELERON PHARMA INC COM00434H10839,938905,017SH SOLE 905,01700
ADMA BIOLOGICS INC COM00089910414,5426,521,102SH SOLE 6,521,10200
ADVERUM BIOTECHNOLOGIES INC COM00773U108960300,000SH SOLE 300,00000
AKEBIA THERAPEUTICS INC COM00972D1059,1821,703,440SH SOLE 1,703,44000
ALBIREO PHARMA INC COM01345P10639,5061,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INC COM01438T10624,6843,085,458SH SOLE 3,085,45800
ALLENA PHARMACEUTICALS INCCOM018119107704132,300SH SOLE 132,30000
ALLIQUA BIOMEDICAL INCCOM PAR019621309214114,730SH SOLE 114,73000
ALLOGENE THERAPEUTICS INC COM01977010641,5741,543,790SH SOLE 1,543,79000
ALNYLAM PHARMACEUTICALS INC COM02043Q10718,462262,241SH SOLE 262,24100
AMARIN CORP PLC SPONS ADR NEW02311120664,5534,875,600SH SOLE 4,875,60000
AMEDISYS INC COM0234361084223,672SH SOLE 3,67200
AMICUS THERAPEUTICS INC COM03152W109191,70120,724,424SH SOLE 20,724,42400
ANI PHARMACEUTICALS INC NOTE 3.000%12/000182CAA17,3837,500,000PRN SOLE 7,500,00000
AQUESTIVE THERAPEUTICS INC COM3843E104713,3142,113,400SH SOLE 2,113,40000
ARENA PHARMACEUTICALS INC COM NEW04004760755,6051,430,171SH SOLE 1,430,17100
ARGENX SE SPONSORED ADR04016X10153,889560,941SH SOLE 560,94100
ARROWHEAD PHARMACEUTICALS INC COM04280A1003,582300,000SH SOLE 300,00000
ASCENDIS PHARMA A S SPONSORED ADR04351P10163,0431,052,647SH SOLE 1,052,64700
ATHENEX INC COM04685N10332,5505,096,022SH SOLE 5,096,02200
AXONICS MODULATION TECH INCCOM05465P10110,935751,000SH SOLE 751,00000
BLUEPRINT MEDICINES CORP COM09627Y10943,484857,326SH SOLE 857,32600
CAREDX INC COM14167L1031,03744,128SH SOLE 44,12800
CLEMENTIA PHARMACEUTICALS INC COM18557510717,6401,500,000SH SOLE 1,500,00000
COLLEGIUM PHARMACEUTICAL INC COM19459J1047,374445,000SH SOLE 445,00000
CONCERT PHARMACEUTICALS INC COM20602210522,8231,873,779SH SOLE 1,873,77900
CRINETICS PHARMACEUTICALS INC COM22663K10777,6122,587,953SH SOLE 2,587,95300
CYMABAY THERAPEUTICS INC COM23257D10319,3822,462,821SH SOLE 2,462,82100
CYTOMX THERAPEUTICS INC COM23284F10543,5882,911,715SH SOLE 2,911,71500
DBV TECHNOLOGIES S A SPONSORED ADR23306J1015,309826,960SH SOLE 826,96000
DEXCOM INCCOM2521311074423,733SH SOLE 3,73300
DOVA PHARMACEUTICALS INC COM25985T10223,6933,125,851SH SOLE 3,125,85100
EDIOS THERAPEUTICS INCCOM28249H1049,452686,922SH SOLE 686,92200
EHEALTH INC COM28238P1092,11355,021SH SOLE 55,02100
EIGER BIOPHARMACEUTICALS INC COM28249U1051,421139,890SH SOLE 139,89000
ESTABLISHMENT LABS HLDGS INCCOMG3124910815,878614,242SH SOLE 614,24200
FERRARI N.V. COMN3167Y1036106,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES N.SHSN3173810289462,000SH SOLE 62,00000
FOAMIX PHARMACEUTICALS LTD SHSM4613510515,8504,661,824SH SOLE 4,661,82400
GLAUKOS CORP COM3773221024177,466SH SOLE 7,46600
GLOBAL BLOOD THERAPEUTICS INCOM37890U108222,7265,425,726SH SOLE 5,425,72600
IMMUNOMEDICS INC COM45290710810,500700,000SH SOLE 700,00000
IMMUNOMEDICS INC COM452907108308200,000SHCallSOLE 200,00000
INVACARE CORPCOM461203101860200,000SH SOLE 200,00000
INVITAE CORP COM46185L10320,6091,863,406SH SOLE 1,863,40600
IOVANCE BIOTHERAPEUTICS INC COM462260100108,33312,241,111SH SOLE 12,241,11100
KADMON HLDGS INCCOM48283N10627,38413,165,746SH SOLE 13,165,74600
KODIAK SCIENCES INC COM50015M10922,2593,135,199SH SOLE 3,135,19900
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 250345960441,0224,313,611SH SOLE 4,313,61100
MARKER THERAPEUTICS INCCOM57055L10711,1002,000,000SH SOLE 2,000,00000
MEI PHARMA INCCOM NEW55279B20211,6174,400,440SH SOLE 4,400,44000
MEIRAGTX HOLDINGS PLC COMG5966510245,3404,703,398SH SOLE 4,703,39800
MERIT MEDICAL SYSTEMS INC COM58988910452,177949,198SH SOLE 949,19800
MIRATI THERAPEUTICS INCCOM60468T1055,250125,875SH SOLE 125,87500
MOLECULAR TEMPLATES INC COM6085501097,1071,974,133SH SOLE 1,974,13300
MOMENTA PHARMACEUTICALS INCCOM60877T10031,1322,825,000SH SOLE 2,825,00000
MOTUS GI HOLDINGS INC COM62014P1089,9843,210,542SH SOLE 3,210,54200
MYOKARDIA INC COM62857M10553,5031,075,216SH SOLE 1,075,21600
NEPTUNE WELLNESS SOLUTIONS ICOM64079L10517,8498,891,452SH SOLE 8,891,45200
NEUROCRINE BIOSCIENCES INC COM64125C109315,3634,608,554SH SOLE 4,608,55400
ONCOMED PHARMACEUTICALS INC COM68234X1021,2841,719,111SH SOLE 1,719,11100
ONCOSEC MEDICAL INC COM68234L2073250,000SH SOLE 50,00000
ORCHARD THERAPEUTICS PLC ADS68570P1018,207521,800SH SOLE 521,80000
OUTLOOK THERAPEUTICS INC*W EXP 02/18/20169012T11572420,875SH SOLE 420,87500
PENUMBRA INC COM70975L1072,03716,338SH SOLE 16,33800
PERNIX THERAPEUTICS HLDGS INDBCV 4,250% 4/071426VAK46421,000,000PRN SOLE 1,000,00000
PROQR THERAPEUTICS N.V. SHS EURON7154210911,250722,523SH SOLE 722,52300
PROTAGONIST THERAPEUTICS INC COM4366E10299,1901,365,579SH SOLE 1,365,57900
QUOTIENT LTD COMG7326810766,02910,789,054SH SOLE 10,789,05400
REGENXBIO INCCOM75901B10726,894645,726SH SOLE 645,72600
RETROPHIN INC COM76129910649,7823,342,038SH SOLE 3,342,03800
RHYTHM PHARMACEUTICALS INC COM76243J10513,763509,186SH SOLE 509,18600
ROCKET PHARMACEUTICALS INC COM77313F1063,495240,173SH SOLE 240,17300
SAGE THERAPEUTICS INC COM78667J10813,110147,315SH SOLE 147,31500
SI-BONE INC COM82570410930715,000SH SOLE 15,00000
SIERRA ONCOLOGY INC COM82640U1073,4132,666,190SH SOLE 2,666,19000
SOLID BIOSCIENCES INC COM83422E105141,835SHCallSOLE 1,83500
SOLID BIOSCIENCES INC COM83422E105105,2493,927,222SH SOLE 3,927,22200
STAAR SURGICAL CO COM PAR $ 0.0185231230540512,953SH SOLE 12,95300
SYNLOGIC INC COM87166L1006,049867,852SH SOLE 867,85200
TANDEM DIABETES CARE INC COM NEW87537220347912,844SH SOLE 12,84400
TELADOC HEALTH INC COM87918A1052,97460,000SH SOLE 60,00000
THERAPEUTICSMD INC COM88338N1075,7151,500,000SH SOLE 1,500,00000
TRANSLATE BIO INC COM89374L1043,167435,000SH SOLE 435,00000
UNIQURE NVSHSN900641015,946220,707SH SOLE 220,70700
UROVANT SCIENCES LTD SHSG9381B1083,915625,359SH SOLE 625,35900
VACCINEX INC COM91864010319050,000SH SOLE 50,00000
VAPOTHERM INCCOM92210710724,4641,226,315SH SOLE 1,226,31500
VBI VACCINES INC COM NEW91822J10338,32223,951,556SH SOLE 23,951,55600
VERICEL CORP COM92346J10848828,090SH SOLE 28,09000
VERRICA PHARMACEUTICALS INC COM92511W10827,7943,410,412SH SOLE 3,410,41200
VERU INC COM92536C1031,8531,425,000SH SOLE 1,425,00000
VIEWRAY INCCOM92672L10721,7153,905,650SH SOLE 3,905,65000
WAVE LIFE SCIENCES LTDSHSY953081052,50159,498SH SOLE 59,49800
XENCOR INC COM98401F1056,833196,810SH SOLE 196,81000
ZOGENIX INC COM98978L204138,1913,790,216SH SOLE 3,790,21600
ZOGENIX INC COM98978L204410200,000SHPutSOLE 200,00000
ZYMEWORKS INC COM98985W1027,196573,890SH SOLE 573,89000