The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INC W EXP 12/24/20100289Y1155,145659,636SH SOLE 659,63600
ABEONA THERAPEUTICS INC COM00289Y1073,078240,459SH SOLE 240,45900
ABIOMED INC COM00365410010,70423,800SH SOLE 23,80000
ACCELERON PHARMA INC COM00434H10887,4591,528,205SH SOLE 1,528,20500
ACHILLION PHARMACEUTICALS INCOM00448Q2013,6801,000,000SH SOLE 1,000,00000
ADAMAS PHARMACEUTICALS INC COM00548A1068,449422,015SH SOLE 422,01500
ADAMIS PHARMACEUTICALS CORP COM NEW00547W208481137,500SH SOLE 137,50000
ADMA BIOLOGICS INC COM00089910440,4966,521,102SH SOLE 6,521,10200
AKEBIA THERAPEUTICS INC COM00972D10521,6292,449,521SH SOLE 2,449,52100
ALBIREO PHARMA INC COM01345P10656,1751,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INC COM01438T10642,5793,085,458SH SOLE 3,085,45800
ALLENA PHARMACEUTICALS INC COM0181191072,685250,000SH SOLE 250,00000
ALLIQUA BIOMEDICAL INC COM PAR019621309961423,394SH SOLE 423,39400
ALNYLAM PHARMACEUTICALS INC COM02043Q107104,8481,197,994SH SOLE 1,197,99400
AMARIN CORP PLC SPONS ADR NEW0231112069,928610,200SH SOLE 610,20000
AMICUS THERAPEUTICS INC COM03152W109250,19620,694,424SH SOLE 20,694,42400
ANI PHARMACEUTICALS INCNOTE 3.000%12/000182CAA17,9427,500,000PRN SOLE 7,500,00000
AQUESTIVE THERAPEUTICS INC COM03843E10420,1371,150,000SH SOLE 1,150,00000
ARENA PHARMACEUTICALS INC COM NEW04004760762,9081,366,978SH SOLE 1,366,97800
ARGENX SE SPONSORED ADR04016X10142,541560,941SH SOLE 560,94100
ARROWHEAD PHARMACEUTICALS INC COM04280A1007,006365,445SH SOLE 365,44500
ARVINAS INC COM04335A1052,109125,000SH SOLE 125,00000
ASCENDIS PHARMA A SSPONSORED ADR04351P10176,0081,072,647SH SOLE 1,072,64700
ATHENEX INC COM04685N10344,5922,869,528SH SOLE 2,869,52800
BEIGENE LTD SPONSORED ADR07725L1029825,700SH SOLE 5,70000
BIOHAVEN PHARMACEUTICAL HLDG CO LCOMG1119610537,210990,943SH SOLE 990,94300
BIOLIFE SOLUTIONS INC COM09062W20451429,376SH SOLE 29,37600
BLUEPRINT MEDICINES CORP COM09627Y10973,466941,147SH SOLE 941,14700
CAPITAL SR LIVING CORPCOM140475104946100,173SH SOLE 100,17300
CAPRICOR THERAPEUTICS INC COM14070B10144,000SH SOLE 4,00000
CAREDX INC COM14167L1037,521260,676SH SOLE 260,67600
CASI PHARMACEUTICALS INC COM14757U10920443,682SH SOLE 43,68200
CLOVIS ONCOLOGY INC COM1894641004,406150,000SH SOLE 150,00000
CORIUM INTERNATIONAL INC COM21887L10760,4566,357,133SH SOLE 6,357,13300
CRINETICS PHARMACEUTICALS INC COM22663K10774,1442,587,953SH SOLE 2,587,95300
CYMABAY THERAPEUTICS INC COM23257D10330,3902,742,821SH SOLE 2,742,82100
CYTOMX THERAPEUTICS INC COM23284F10549,2422,661,715SH SOLE 2,661,71500
DBV TECHNOLOGIES S A SPONSORED ADR23306J10167,6043,009,998SH SOLE 3,009,99800
DOVA PHARMACEUTICALS INC COM25985T10265,5493,125,851SH SOLE 3,125,85100
EHEALTH INC COM28238P1096,393226,220SH SOLE 226,22000
EIDOS THERAPEUTICS INC COM28249H1046,855686,922SH  SOLE 686,92200
EIGER BIOPHARMACEUTICALS INC REGISTERED SHSCOM28249U1051,892157,679SH SOLE 157,67900
ENDOCYTE INC REGISTERED SHSCOM29269A10243,3652,441,700SH SOLE 2,441,70000
ESTABLISHMENT LABS HLDGS INCCOMG3124910815,304635,000SH SOLE 635,00000
EVOLENT HEALTH INC CL A30050B1013,124110,000SH SOLE 110,00000
FERRARI N.V.COMN3167Y1038496,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES N.COMN317381021,08662,000SH SOLE 62,00000
FOAMIX PHARMACEUTICALS LTDSHSM4613510517,8063,107,424SH SOLE 3,107,42400
G1 THERAPEUTICS INC COM3621LQ10973514,055SH SOLE 14,05500
GERON CORPCOM3741631033,6801,950,000SHPutSOLE 1,950,00000
GERON CORPCOM37416310310200,000SHCallSOLE 200,00000
GLOBAL BLOOD THERAPEUTICS INCOM37890U108195,6585,148,910SH SOLE 5,148,91000
HISTOGENICS CORP COM43358V1096561,203,399SH SOLE 1,203,39900
HUMANA INCCOM44485910211,84835,000SH SOLE 35,00000
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR44842L10332210,000SH SOLE 10,00000
IMMUNOMEDICS INC COM45290710844421,335SH SOLE 21,33500
INTERCEPT PHARMACEUTICALS INCOM45845P1087115,627SH SOLE 5,62700
INTUITIVE SURGICAL INCCOM NEW46120E60241,61572,500SH SOLE 72,50000
INVACARE CORPCOM4612031012,910200,000SH SOLE 200,00000
INVITAE CORP COM46185L10331,1361,861,100SH SOLE 1,861,10000
IOVANCE BIOTHERAPEUTICS INC COM46226010082,0147,290,199SH SOLE 7,290,19900
IRHYTHM TECHNOLOGIES INCCOM45005610615,992168,939SH SOLE 168,93900
KADMON HLDGS INCCOM48283N10643,97313,165,746SH SOLE 13,165,74600
KINIKSA PHARMACEUTICALS LTD COM CL AG5269C1011,35653,169SH SOLE 53,16900
LA JOLLA PHARMACEUTICAL COCOM par $.0001 250345960486,8334,313,611SH SOLE 4,313,61100
LIVANOVA PLC SHSG5509L10113,761111,000SH SOLE 111,00000
MADRIGAL PHARMACEUTICALS INCCOM5588681054742,213SH SOLE 2,21300
MARINUS PHARMACEUTICALS INC COM56854Q1019,077907,732SH SOLE 907,73200
MEIRAGTX HOLDINGS PLC COMG5966510263,9664,703,398SH SOLE 4,703,39800
MERIT MED SYS INCCOM58988910461,093994,198SH SOLE 994,19800
MOLECULAR TEMPLATES INCCOM60855010910,6411,974,133SH SOLE 1,974,13300
MOMENTA PHARMACEUTICALS INC COM60877T10064424,489SH SOLE 24,48900
MOTUS GI HOLDINGS INC REGISTERED SHSCOM62014P10814,3332,810,542SH SOLE 2,810,54200
MYOKARDIA INC COM62857M10571,0141,089,169SH SOLE 1,089,16900
NATERA INC COM63230710457524,000SH SOLE 24,00000
NEPTUNE WELLNESS SOLUTIONS ICOM64079L10534,4988,891,452SH SOLE 8,891,45200
NEUROCRINE BIOSCIENCES INC COM64125C109587,3634,777,254SH SOLE 4,777,25400
NEURONETICS INC COM64131A1054,345135,500SH SOLE 135,50000
NUVECTRA CORP COM67075N1082,967135,000SH SOLE 135,00000
ODONATE THERAPEUTICS INCCOM6760791061,941100,000SH SOLE 100,00000
ONCOBIOLOGICS INC*W EXP 02/18/20168235M1136420,875SH SOLE 420,87500
ONCOMED PHARMACEUTICALS INC COM68234X1025,5562,620,897SH SOLE 2,620,89700
ONCOSEC MED INCCOM68234L2077050,000SH SOLE 50,00000
PERNIX THERAPEUTICS HLDGS INDBCV 4.250% 4/071426VAK44131,000,000PRN SOLE 1,000,00000
POLARITYTE INC COM7310941086,433336,818SH SOLE 336,81800
PROQR THERAPEUTICS N.V. SHS EURON7154210914,725761,000SH SOLE 761,00000
PROTAGONIST THERAPEUTICS INCCOM4366E102910,9731,066,415SH SOLE 1,066,41500
PROTEON THERAPEUTICS INC COM74371L109469240,488SH SOLE 240,48800
PTC THERAPEUTICS INC COM69366J20091019,367SH SOLE 19,36700
QUOTIENT LTD SHSG7326810766,3578,789,054SH SOLE 8,789,05400
REATA PHARMACEUTICALS INCCOM75615P1037919,677SH SOLE 9,67700
REGENXBIO INC COM75901B10735,536470,672SH SOLE 470,67200
RETROPHIN INC COM76129910660,4833,212,871SH SOLE 3,212,87100
RHYTHM PHARMACEUTICALS INCCOM76243J10519,374664,186SH SOLE 664,18600
SENSEONICS HLDGS INCCOM81727U105549115,000SH SOLE 115,00000
SIERRA ONCOLOGY INCCOM82640U1075,4403,200,000SH SOLE 3,200,00000
SOLID BIOSCIENCES INC COM3422E1055401,835SHCallSOLE 1,83500
SOLID BIOSCIENCES INC COM3422E1055185,2863,927,222SH SOLE 3,927,22200
SYNLOGIC INC COM87166L10013,398942,852SH SOLE 942,85200
TABULA RASA HEALTHCARE INC COM8733791011,19014,663SH SOLE 14,66300
TESARO INC COM8815691077,802200,000SH SOLE 200,00000
THERAPEUTICSMD INCCOM88338N1079,8401,500,000SH SOLE 1,500,00000
TRANSLATE BIO INC COM89374L1045,000500,000SH SOLE 500,00000
UNIQURE NVSHSN9006410135,402972,831SH SOLE 972,83100
UROVANT SCIENCES LTD SHSG9381B1085,552462,659SH SOLE 462,65900
VACCINEX INC COM91864010336550,000SH SOLE 50,00000
VBI VACCINES INC REGISTERED SHSCOM91822J10323,3919,665,843SH SOLE 9,665,84300
VERICEL CORP COM92346J10838527,211SH SOLE 27,21100
VERRICA PHARMACEUTICALS INCCOM92511W10855,4193,410,412SH SOLE 3,410,41200
VERU INC COM92536C1032,0241,425,000SH SOLE 1,425,00000
VIEWRAY INC REGISTERED SHSCOM92672L10734,6323,700,000SH SOLE 3,700,00000
VIKING THERAPEUTICS INC COM92686J1061,11964,261SH SOLE 64,26100
WAVE LIFE SCIENCES LTDCOMY9530810511,700234,019SH SOLE 234,01900
XENCOR INC COM98401F10532,271828,095SH SOLE 828,09500
XERIS PHARMACEUTICALS INC COM98422L1073,527200,627SH SOLE 200,62700
ZOGENIX INC COM98978L204188,8583,807,632SH SOLE 3,807,63200
ZYMEWORKS INC COM98985W10216,9111,123,890SH SOLE 1,123,89000