X0306 4/A 2018-07-18 2018-07-20 0001658247 Crinetics Pharmaceuticals, Inc. CRNX 0001224962 PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 0001164426 EDELMAN JOSEPH 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 0 0 1 0 Common Stock 2018-07-18 4 P 0 307648 21.30 A 307648 I See footnotes Common Stock 2018-07-20 4 C 0 1880305 A 2187953 I See footnotes Common Stock 2018-07-20 4 P 0 400000 17.00 A 2587953 I See footnotes Series B Preferred Stock 2018-07-20 4 C 0 6186205 D Common Stock 1880305 0 I See footnote This Form 4/A is being filed to report the July 18, 2018 purchase and correct the number of shares held by the Master Fund (as defined in Footnote 2). The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. The shares of the Issuer's Series B Preferred Stock automatically converted into shares of the Issuer's Common Stock, for no additional consideration, at a ratio of 3.29 to 1 share, immediately prior to the consummation of the Issuer's initial public offering. The Series B Preferred Stock had no expiration date. /s/ Jospeh Edelman - for Perceptive Life Sciences Master Fund Ltd., By: Perceptive Advisors LLC, its investment manager, By: Joseph Edelman, its managing member 2018-08-27 /s/ Jospeh Edelman - for Perceptive Advisors LLC, By: Joseph Edelman, its managing member 2018-08-27 /s/ Joseph Edelman 2018-08-27