The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INCW EXP 12/24/20100289Y11512,8101,259,636SH SOLE 1,259,63600
ABEONA THERAPEUTICS INC COM00289Y10795459,662SH SOLE 59,66200
ABIOMED INCCOM00365410014,99036,646SH SOLE 36,64600
ACASTI PHARMA INC CL A NEW 00430K402117206,677SH SOLE 206,67700
ACCELERON PHARMA INCCOM00434H10874,1491,528,205SH SOLE 1,528,20500
ACHILLION PHARMACEUTICALS INC COM00448Q2012,8301,000,000SH SOLE 1,000,00000
ADAMAS PHARMACEUTICALS INC COM00548A10628,0041,084,159SH SOLE 1,084,15900
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR00653A10758549,302SH SOLE 49,30200
ADMA BIOLOGICS INC COM00089910429,4106,521,102SH SOLE 6,521,10200
ADVERUM BIOTECHNOLOGIES INC COM00773U10842880,845SH SOLE 80,84500
AEGLEA BIOTHERAPEUTICS INC COM00773J10327225,694SH SOLE 25,69400
AGILE THERAPEUTICS INCCOM00847L1001,7443,530,000SH SOLE 3,530,00000
AKEBIA THERAPEUTICS INCCOM00972D10522,1102,215,400SH SOLE 2,215,40000
ALBIREO PHARMA INC COM01345P10660,5041,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INC COM01438T10624,5293,085,458SH SOLE 3,085,45800
ALEXION PHARMACEUTICALS INC COM01535110957,537463,450SH SOLE 463,45000
ALLENA PHARMACEUTICALS INCCOM0181191073,258250,000SH SOLE 250,00000
ALLIQUA BIOMEDICAL INCCOM PAR 019621309867423,394SH SOLE 423,39400
ALNYLAM PHARMACEUTICALS INC COM02043Q107181,9021,846,911SH SOLE 1,846,91100
AMICUS THERAPEUTICS INC COM03152W109312,78220,024,424SH SOLE 20,024,42400
ANI PHARMACEUTICALS INCNOTE 3.005 12/000182CAA18,4587,500,000PRN SOLE 7,500,00000
ARENA PHARMACEUTICALS INC COM NEW04004760736,710841,978SH SOLE 841,97800
ARGENX SE ADRADR04016X10143,879529,560SH SOLE 529,56000
ARRAY BIOPHARMA INC COM04269X10567340,133SH SOLE 40,13300
ARROWHEAD PHARMACEUTICALS INC COM04280A1004,970365,445SH SOLE 365,44500
ASCENDIS PHARMA A SSPONSORED ADR04351P10171,3521,072,647SH SOLE 1,072,64700
ASSEMBLY BIOSCIENCES INC COM0453961085,909150,695SH SOLE 150,69500
ATHENAHEALTH INCCOM04685W10323,871150,000SH SOLE 150,00000
ATHENEX INCCOM04685N1033,545190,000SH SOLE 190,00000
AUDENTES THERAPEUTICS INCCOM05070R10425,234660,406SH SOLE 660,40600
AVEO PHARMACEUTICALS INC COM0535881094,2741,891,192SH SOLE 1,891,19200
AXOGEN INC COM05463X1068,291165,000SH SOLE 165,00000
AZURRX BIOPHARMA INCCOM05502L105730227,272SH SOLE 227,27200
BEIGENE LTD SPONSORED ADR07725L1028765,700SH SOLE 5,70000
BIOHAVEN PHARMACEUTICAL HOLDING CO LCOMG11196105108,4292,743,647SH SOLE 2,743,64700
BLUEPRINT MEDICINES CORP COM09627Y10961,014961,147SH SOLE 961,14700
CAPITAL SR LIVING CORP COM1404751041,069100,173SH SOLE 100,17300
CAPRICOR THERAPEUTICS INC COM14070B10154,000SH SOLE 4,00000
CAREDX INC COM14167L1035,724467,676SH SOLE 467,67600
CASI PHARMACEUTICALS INC COM14757U10936043,682SH SOLE 43,68200
CHAMPIONS ONCOLOGY INCCOM NEW1589908122,326366,972SH SOLE 366,97200
CLEARSIDE BIOMEDICAL INC COM1850631047,599707,581SH SOLE 707,58100
COLLEGIUM PHARMACEUTICAL INC COM19459J10457724,213SH SOLE 24,21300
CORIUM INTERNATIONAL INC COM21887L10750,9216,357,133SH SOLE 6,357,13300
CYMABAY THERAPEUTICS INC COM23257D10336,8082,742,821SH SOLE 2,742,82100
CYTOMX THERAPEUTICS INCCOM23284F10543,9301,921,715SH SOLE 1,921,71500
DBV TECHNOLOGIES SA SHS SPONSORED AMERICAN DEPOSITADR23306J10140,6672,108,198SH SOLE 2,108,19800
DOVA PHARMACEUTICALS INCCOM25985T10293,5253,125,851SH SOLE 3,125,85100
EIDOS THERAPEUTICS INC COM28249H10413,971686,922SH SOLE 686,92200
EIGER BIOPHARMACEUTICALS INC COM28249U1051,923157,679SH SOLE 157,67900
ELLOX PHARMACEUTICALS INC COM29014R103502,961SH SOLE 2,96100
ENDOCYTE INC COM29269A10226,5191,921,700SH SOLE 1,921,70000
EVOLENT HEALTH INC CL A 30050B1011,47470,000SH SOLE 70,00000
FERRARI N.V. COMN3167Y1038376,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES N. SHSN317381021,17162,000SH SOLE 62,00000
FLEXION THERAPEUTICS INCCOM33938J1067,962307,989SH SOLE 307,98900
FOAMIX PHARMACEUTICALS LTDSHSM461351055,5981,117,324SH SOLE 1,117,32400
G1 THERAPEUTICS INC COM3621LQ10961114,055SH SOLE 14,05500
GALAPAGOS NV SPON ADR36315X10113,908150,875SH SOLE 150,87500
GERON CORP COM3741631032,8872,350,000SHPutSOLE 2,350,00000
GERON CORP COM37416310335200,000SHCallSOLE 200,00000
GLOBAL BLOOD THERAPEUTICS INCOM37890U108218,2664,828,910SH SOLE 4,828,91000
GTX INC DELCOM NEW40052B20722,9881,501,501SH SOLE 1,501,50100
HISTOGENICS CORPCOM43358V1095,5082,203,277SH SOLE 2,203,27700
HUMANA INC COM44485910244,114148,218SH SOLE 148,21800
HUTCHISON CHINA MEDITECH LTD SPONSORED ADR44842L10330110,000SH SOLE 10,00000
INTUITIVE SURGICAL INC COM NEW46120E60247,848100,000SH SOLE 100,00000
INVACARE CORPCOM4612031013,720200,000SH SOLE 200,00000
INVITAE CORP COM46185L10314,8552,021,100SH SOLE 2,021,10000
IOVANCE BIOTHERAPEUTICS INC COM46226010074,9085,852,202SH SOLE 5,852,20200
IRHYTHM TECHNOLOGIES INC COM45005610624,989308,006SH SOLE 308,00600
KADMON HLDGS INCCOM48283N10652,53113,165,746SH SOLE 13,165,74600
KINIKSA PHARMACEUTICALS LTD COMG5269C1011,928111,111SH SOLE 111,11100
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2503459604125,8284,313,611SH SOLE 4,313,61100
LOXO ONCOLOGY INC COM5488621016533,765SH SOLE 3,76500
MADRIGAL PHARMACEUTICALS INC COM5588681059,01032,213SH SOLE 32,21300
MARINUS PHARMACEUTICALS INC COM56854Q1016,417907,732SH SOLE 907,73200
MEIRAGTX HOLDINGS PLC COMG5966510253,9004,703,398SH SOLE 4,703,39800
MENLO THERAPEUTICS INC COM58685810210,0791,241,287SH SOLE 1,241,28700
MERIT MED SYS INCCOM58988910455,3991,082,013SH SOLE 1,082,01300
MIRATI THERAPEUTICS INC COM60468T10535,160713,191SH SOLE 713,19100
MOLECULAR TEMPLATES INC COM6085501093,787724,133SH SOLE 724,13300
MOMENTA PHARMACEUTICALS INC COM60877T10050124,489SH SOLE 24,48900
MOTUS GI HLDGS INCCOM62014P10820,2072,810,542SH SOLE 2,810,54200
MYOKARDIA INCCOM62857M10554,0781,089,169SH SOLE 1,089,16900
NEKTAR THERAPEUTICS COM6402681082966,057SH SOLE 6,05700
NEPTUNE TECHNOLOGIES AND BIORESOCOM64077P10820,3798,574,015SH SOLE 8,574,01500
NEUROCRINE BIOSCIENCES INC COM64125C109463,2264,715,250SH SOLE 4,715,25000
NEURONETICS INC COM64131A1053,340125,500SH SOLE 125,50000
NUVECTRA CORP COM67075N1083,274159,466SH SOLE 159,46600
ODONATE THERAPEUTICS INC COM6760791063,312150,000SH SOLE 150,00000
ONCOMED PHARMACEUTICALS COM68234X1026,0542,620,897SH SOLE 2,620,89700
ONCOSEC MED INCCOM68234L2076950,000SH SOLE 50,00000
PERNIX THERAPEUTICS HLDGS INDBVC 4.250% 4/071426VAK44261,000,000PRN SOLE 1,000,00000
PROTEON THERAPEUTICS INC COM74371L109819334,116SH SOLE 334,11600
PTC THERAPEUTICS INC COM69366J20065319,367SH SOLE 19,36700
PUMA BIOTECHNOLOGY INC COM74587V107187100,000SHCallSOLE 100,00000
PUMA BIOTECHNOLOGY INC COM74587V10727,480464,579SH SOLE 464,57900
QUOTIENT LTD SHSG7326810752,0586,483,020SH SOLE 6,483,02000
REGENXBIO INCCOM75901B10762,215867,106SH SOLE 867,10600
RETROPHIN INCCOM76129910657,3873,212,871SH SOLE 3,212,87100
RHYTHM PHARMACEUTICALS INC COM76243J10525,029800,686SH SOLE 800,68600
SANGAMO THERAPEUTICS INC COM80067710635525,000SH SOLE 25,00000
SENSEONICS HLDGS INCCOM81727U105473115,000SH SOLE 115,00000
SIERRA ONCOLOGY INC COM82640U10713,3204,500,000SH SOLE 4,500,00000
SOLID BIOSCIENCES INC COM3422E1055141,7083,977,222SH SOLE 3,977,22200
STRONGBRIDGE BIOPHARMA PLC COMG853471051,650275,000SH SOLE 275,00000
SYNLOGIC INC COM87166L1009,268942,852SH SOLE 942,85200
TABULA RASA HEALTHCARE INC COM87337910193614,663SH SOLE 14,66300
TELADOC INC COM87918A10511,320195,000SH SOLE 195,00000
TESARO INC COM8815691074,447100,000SH SOLE 100,00000
TG THERAPEUTICS INC COM88322Q108258100,000SHPutSOLE 100,00000
TRANSLATE BIO INC COM89374L1046,325500,000SH SOLE 500,00000
UNIQURE NV SHSN9006410154,6071,444,628SH SOLE 1,444,62800
VBI VACCINES INC COM NEW91822J10326,5819,665,843SH SOLE 9,665,84300
VERICEL CORP COM92346J10826427,211SH SOLE 27,21100
VERONA PHARMA PLC SPONSORED ADR92505010630722,327SH SOLE 22,32700
VERRICA PHARMACEUTICALS INC COM92511W10867,2873,410,412SH SOLE 3,410,41200
VERTEX PHARMACEUTICALS INC COM92532F10012,90075,898SH SOLE 75,89800
VICAL INCCOM NEW 9256022031,3141,142,858SH SOLE 1,142,85800
VIEWRAY INCCOM92672L10751975,000SH SOLE 75,00000
VITAL THERAPIES INC COM92847R104405150,000SHPutSOLE 150,00000
WAVE LIFE SCIENCES LTD SHSY9530810510,817282,798SH SOLE 282,79800
XENCOR INCCOM98401F10539,5301,068,095SH SOLE 1,068,09500
XERIS PHARMACEUTICALS INC COM98422L1078,541450,000SH SOLE 450,00000
ZOGENIX INCCOM98978L204175,4893,970,357SH SOLE 3,970,35700
ZYMEWORKS INC COM98985W10215,9201,123,890SH SOLE 1,123,89000