The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INCW EXP 12/24/20100289Y11511,9661,259,636SH SOLE 1,259,63600
ABEONA THERAPEUTICS INC COM00289Y10714,180998,162SH SOLE 998,16200
ABIOMED INCCOM00365410096,739332,449SH SOLE 332,44900
ABLYNX NVSPONSORED ADR00372Y10520,187370,000SH SOLE 370,00000
ACADIA PHARMACEUTICALS INCCOM0042251086,179275,000SH SOLE 275,00000
ACASTI PHARMA INCCOM00430K402190186,559SH SOLE 186,55900
ACCELERON PHARMA INCCOM00434H10859,2861,516,259SH SOLE 1,516,25900
ACHILLION PHARMACEUTICALS INCCOM00448Q2013,7101,000,000SH SOLE 1,000,00000
ADAMAS PHARMACEUTICALS INCCOM00548A10615,057630,000SH SOLE 630,00000
ADMA BIOLOGICS INCCOM00089910417,5773,821,102SH SOLE 3,821,10200
ADVAXIS INCCOM NEW0076242082,5351,500,000SH SOLE 1,500,00000
ADVERUM BIOTECHNOLOGIES INCCOM00773U10846980,845SH SOLE 80,84500
AGILE THERAPEUTICS INCCOM00847L1009,0723,530,000SH SOLE 3,530,00000
AGIO PHARMACEUTICALS INCCOM00847X10420,445250,000SH  SOLE 250,00000
AKCEA THERAPEUTICS INCCOM00972L1072,48897,144SH SOLE 97,14400
AKEBIA THERAPEUTICS INCCOM00972D10523,4672,462,400SH SOLE 2,462,40000
ALBIREO PHARMA INCCOM01345P10655,5101,704,330SH SOLE 1,704,33000
ALDEYRA THERAPEUTICS INCCOM01438T10623,1413,085,458SH SOLE 3,085,45800
ALEXION PHARMACEUTICALS INCCOM01535110997,355873,450SH SOLE 873,45000
ALLENA PHARMACEUTICALS INCCOM0181191072,755250,000SH SOLE 250,00000
ALLIQUA BIOMEDICAL INCCOM PAR019621309821423,394SH SOLE 423,39400
ALNYLAM PHARMACEUTICALS COM02043Q107152,5431,280,802SH SOLE 1,280,80200
AMICUS THERAPEUTICS INCCOM03152W109301,16720,024,424SH SOLE 20,024,42400
ANAPTYSBIO INCCOM03272410624,696237,281SH SOLE 237,28100
ANI PHARMACEUTICALS INC NOTE 3.000%12/000182CAA18,2147,500,000PRN SOLE 7,500,00000
ARENA PHARMACEUTICALS INCCOM NEW 0400476076,793171,978SH SOLE 171,97800
ARGENX SE-ADRCOM04016X10143,225537,361SH SOLE 537,36100
ARRAY BIOPHARMA INCCOM04269X10565540,133SH SOLE 40,13300
ARROWHEAD PHARMACEUTICALS INCCOM04280A1002,635365,445SH SOLE 365,44500
ASCENDIS PHARMA A SSPONSORED ADR04351P10164,265982,647SH SOLE 982,64700
ASSEMBLY BIOSCIENCES INCCOM04539610823,421476,626SH SOLE 476,62600
ATHENEX INCCOM04685N1033,232190,000SH SOLE 190,00000
AUDENTES THERAPEUTICS INCCOM05070R10422,724756,215SH SOLE 756,21500
AVADEL PHARMACEUTICALS PLCSPONSORED ADR05337M1049,4471,295,841SH SOLE 1,295,84100
AVEO PHARMACEUTICALS INCCOM0535881097,1292,458,116SH SOLE 2,458,11600
AVEXIS INCCOM05366U10034,158276,400SH SOLE 276,40000
AZURRX BIOPHARMA INCCOM05502L105714227,272SH SOLE 227,27200
BEIGENE LTDSPONSORED 07725L1029585,700SH SOLE 5,70000
BIOGEN INC COM09062X1031150,000SHCallSOLE 50,00000
BIOGEN INC COM09062X1035,47620,000SH SOLE 20,00000
BIOHAVEN PHARMACEUTICAL HLDG CO LCOMG1119610571,2242,927,449SH SOLE 2,927,44900
BLUEPRINT MEDICINES CORPCOM09627Y10994,4911,030,434SH SOLE 1,030,43400
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E2011,260400,000SH SOLE 400,00000
CAPITAL SR LIVING CORPCOM1404751041,077100,173SH SOLE 100,17300
CAPRICOR THERAPEUTICS INCCOM14070B10154,000SH SOLE 4,00000
CAREDX INCCOM14167L1038,2941,040,676SH SOLE 1,040,67600
CASI PHARMACEUTICALS INCCOM14757U10918243,682SH SOLE 43,68200
CATALYST BIOSCIENCES IINCCOM NEW 14888D2081,41955,000SH SOLE 55,00000
CELLECTIS S A SPONSORED ADS 15117K1039,453300,000SH SOLE 300,00000
CHAMPIONS ONCOLOGY INCCOM NEW 15870P3071,335366,973SH SOLE 366,97300
CLEARSIDE BIOMEDICAL INCCOM1850631047,681715,181SH SOLE 715,18100
CORIUM INTERNATIONAL INCCOM21887L10772,9166,357,133SH SOLE 6,357,13300
CUTERA INCCOM23210910860211,981SH SOLE 11,98100
CYMABAY THERAPEUTICS INCCOM23257D10333,7452,802,821SH SOLE 2,802,82100
CYTOMX THERAPEUTICS INCCOM23284F10562,8412,208,812SH SOLE 2,208,81200
DBV TECHNOLOGIES S A SPONSORED ADR 23306J10148,2962,093,498SH SOLE 2,093,49800
DOVA PHARMACEUTICALS INCCOM25985T10275,4202,780,977SH SOLE 2,780,97700
DYNAVAX TECHNOLOGIES CORPCOM NEW 2681582011,10655,713SH SOLE 55,71300
EIGER BIOPHARMACEUTICALS INCCOM28249U1051,553157,679SH SOLE 157,67900
ENANTA PHARMACEUTICALS INCCOM29251M1067399,132SH SOLE 9,13200
ENDOCYTE INCCOM29269A10220,0132,201,700SH SOLE 2,201,70000
ESPERION THERAPEUTICS INC NECOM29664W10577910,769SH SOLE 10,76900
FERRARI N V COMN3167Y1037476,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES NSHSN317381021,27262,000SH SOLE 62,00000
FLEXION THERAPEUTICS INCCOM33938J1066,902307,989SH SOLE 307,98900
FOAMIX PHARMACEUTICALS LTDCOMM461351055,7321,117,324SH SOLE 1,117,32400
GALAPAGOS N V SPON ADR 36315X10120,581206,305SH SOLE 206,30500
GERON CORPCOM374163103600600,000SHPutSOLE 600,00000
GLOBAL BLOOD THERAPEUTICS INCOM37890U108240,9714,989,066SH SOLE 4,989,06600
HISTOGENICS CORPCOM43358V1096,0592,203,277SH SOLE 2,203,27700
HUMANA INCCOM44485910216,32360,718SH SOLE 60,71800
HUTCHISON CHINA MEDITECH LTDSPONSORED ADR 44842L10329610,000SH SOLE 10,00000
INCYTE CORP COM45337C1026,9461,510,000SHCallSOLE 1,510,00000
INCYTE CORP COM45337C1022,230100,000SHPutSOLE 100,00000
INTRA CELLULAR THERAPIES INCCOM46116X1011,47470,000SH SOLE 70,00000
INTUITIVE SURGICAL INCCOM NEW 46120E6024,12810,000SH SOLE 10,00000
INVACARE CORPCOM4612031013,480200,000SH SOLE 200,00000
INVITAE CORPCOM46185L1038,7001,851,100SH SOLE 1,851,10000
IOVANCE BIOTHERAPEUTICS INCCOM462260100104,1416,162,202SH SOLE 6,162,20200
IRHYTHM TECHNOLOGIES INCCOM45005610626,420419,706SH SOLE 419,70600
KADMON HLDGS INCCOM48283N10621,9545,165,746SH SOLE 5,165,74600
LA JOLLA PHARMACEUTICAL COCOM PAR $.0001 2503459604128,4594,313,611SH SOLE 4,313,61100
MADRIGAL PHARMACEUTICALS INCCOM55886810516,645142,522SH SOLE 142,52200
MARINUS PHARMACEUTICALS INCCOM56854Q1013,467907,732SH SOLE 907,73200
MCKESSON CORPCOM58155Q1032,11315,000SH SOLE 15,00000
MENLO THERAPEUTICS INCCOM58685810260,0891,598,958SH SOLE 1,598,95800
MERIT MED SYS INCCOM58988910447,3911,045,013SH SOLE 1,045,01300
MIRATI THERAPEUTICS INCCOM60468T10589329,091SH SOLE 29,09100
MOLECULAR TEMPLATES INCCOM6085501095,793724,133SH SOLE 724,13300
MOTUS GI HLDGS INCCOM62014P10812,5912,810,542SH SOLE 2,810,54200
MYOKARDIA INCCOM62857M10540,732834,679SH SOLE 834,67900
NEKTAR THERAPEUTICS COM6402681086446,057SH SOLE 6,05700
NEPTUNE TECHNOLOGIES BIORESOCOM64077P10824,0928,574,015SH SOLE 8,574,01500
NEUROCRINE BIOSCIENCES INCCOM64125C109394,9124,761,989SH SOLE 4,761,98900
NUVECTRA CORP COM67075N1085,007384,600SH SOLE 384,60000
ODONATE THERAPEUTICS INCCOM6760791063,177150,000SH SOLE 150,00000
ONCOMED PHARMACEUTICALS INCCOM68234X1028,3342,620,897SH SOLE 2,620,89700
ONCOSEC MED INCCOM NEW 68234L2079450,000SH SOLE 50,00000
PERNIX THERAPEUTICS HLDGS INDBVC 4.250% 4/071426VAK44621,000,000PRN SOLE 1,000,00000
PORTOLA PHARMACEUTICALS INC COM73701010814,370440,000SH SOLE 440,00000
PORTOLA PHARMACEUTICALS INC COM737010108158100,000SHPutSOLE 100,00000
PROGENICS PHARMACEUTICALS INCOM7431871061,212162,500SH SOLE 162,50000
PROTEON THERAPEUTICS INCCOM74371L109835334,116SH SOLE 334,11600
PTC THERAPEUTICS INCCOM69366J2008,118300,000SH SOLE 300,00000
PUMA BIOTECHNOLOGY INC COM74587V1071,610200,000SHCallSOLE 200,00000
PUMA BIOTECHNOLOGY INC COM74587V10730,090442,179SH SOLE 442,17900
QUOTIENT LTDCOMG7326810728,4156,033,020SH SOLE 6,033,02000
REGENERON PHARMACEUTICALS COM75886F10733550,000SHCallSOLE 50,00000
REGENXBIO INCCOM75901B10726,301881,106SH SOLE 881,10600
RETROPHIN INCCOM76129910671,8393,212,871SH SOLE 3,212,87100
REVANCE THERAPEUTICS INCCOM76133010919,064618,957SH SOLE 618,95700
RHYTHM PHARMACEUTICALS INCCOM76243J10511,786592,286SH SOLE 592,28600
SANGAMO THERAPEUTICS INCCOM80067710647525,000SH SOLE 25,00000
SELECTA BIOSCIENCES INCCOM8162121046,050593,750SH SOLE 593,75000
SENSEONICS HLDGS INCCOM81727U105345115,000SH SOLE 115,00000
SIERRA ONCOLOGY INCCOM82640U10710,3505,000,000SH SOLE 5,000,00000
SOLID BIOSCIENCES INCCOM3422E105529,4543,927,222SH SOLE 3,927,22200
SPDR SERIES TRUSTS&P BIOTECH78464A8701,548900,000SHPutSOLE 900,00000
STRONGBRIDGE BIOPHARMA PLCSHS USD G853471052,434275,000SH SOLE 275,00000
SYNERGY PHARMACEUTICALS DELCOM NEW 871639308183100,000SH SOLE 100,00000
SYNLOGIC INCCOM87166L1008,844942,852SH SOLE 942,85200
TABULA RASA HEALTHCARE INCCOM87337910156914,663SH SOLE 14,66300
TELADOC INCCOM87918A10520,956520,000SH SOLE 520,00000
TELEFLEX INCCOM87936910610,42940,900SH SOLE 40,90000
UNIQURE NVCOMN9006410132,7741,394,628SH SOLE 1,394,62800
VBI VACCINES INCCOM NEW91822J10333,8309,665,843SH SOLE 9,665,84300
VERICEL CORPCOM92346J10827127,211SH SOLE 27,21100
VERONA PHARMA PLCSPONSORED ADS 9250501061,12356,168SH SOLE 56,16800
VERTEX PHARMACEUTICALS INCCOM92532F10024,756151,898SH SOLE 151,89800
VICAL INC COM9256022031,6571,142,858SH SOLE 1,142,85800
VIEWRAY INCCOM92672L107643100,000SH SOLE 100,00000
VITAL THERAPIES INC COM92847R104454150,000SHPutSOLE 150,00000
VIVEVE MED INCCOM NEW 92852W2041,226334,894SH SOLE 334,89400
WAVE LIFE SCIENCES LTDSHSY9530810518,558462,798SH SOLE 462,79800
XENCOR INCCOM98401F10539,5161,318,095SH SOLE 1,318,09500
ZOGENIX INCCOM NEW98978L204159,0123,970,357SH SOLE 3,970,35700
ZYMEWORKS INCCOM98985W1027,779693,890SH SOLE 693,89000