The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INC *W EXP 12/24/20100289Y11514,6121,259,636SH SOLE 1,259,63600
ABEONA THERAPEUTICS INC COM00289Y10794659,662SH SOLE 59,66200
ABIOMED INCCOM00365410040,293215,000SH SOLE 215,00000
ABLYNX NVSPONSORED ADR00372Y1056,248250,000SH SOLE 250,00000
ACASTI PHARMA INC CL A NEW00430K402176186,559SH SOLE 186,55900
ACCELERON PHARMA INC COM00434H10868,5941,616,259SH SOLE 1,616,25900
ACER THERAPEUTICS INCCOM00444P1082,091150,000SH SOLE 150,00000
ACHILLION PHARMACEUTICALS IN COM00448Q2012,8801,000,000SH SOLE 1,000,00000
ADMA BIOLOGICS INCCOM00089910412,2663,821,102SH SOLE 3,821,10200
AFFIMED NVCOMN01045108869668,214SH SOLE 668,21400
AGILE THERAPEUTICS INCCOM00847L1009,0923,380,000SH SOLE 3,380,00000
AKEBIA THERAPEUTICS INCCOM00972D10529,5531,987,400SH SOLE 1,987,40000
ALBIREO PHARMA INCCOM01345P10633,7921,320,000SH SOLE 1,320,00000
ALDEYRA THERAPEUTICS INCCOM01438T10620,9813,085,458SH SOLE 3,085,45800
ALIGN TECHNOLOGY INCCOM0162551017663,448SH SOLE 3,44800
ALLENA PHARMACEUTICALS INCCOM0181191072,515250,000SH SOLE 250,00000
ALLIQUA BIOMEDICAL INCCOM NEW019621309766423,394SH SOLE 423,39400
ALNYLAM PHARMACEUTICALS INCCOM02043Q107169,0791,330,802SH SOLE 1,330,80200
AMGEN INCCOM0311621008,69550,000SH SOLE 50,00000
AMICUS THERAPEUTICS INCCOM03152W109257,41717,888,597SH SOLE 17,888,59700
ANAPTYSBIO INCCOM03272410676,183756,387SH SOLE 756,38700
ANI PHARMACEUTICALS INC NOTE 3.000%12/000182CAA18,6427,500,000PRN SOLE 7,500,00000
ANTARES PHARMA INCCOM0366421067,4543,745,662SH SOLE 3,745,66200
ARENA PHARMACEUTICALS INCCOM NEW04004760774721,978SH SOLE 21,97800
ARGENX SE SPONSORED ADR04016X10133,929537,361SH SOLE 537,36100
ASSEMBLY BIOSCIENCES INCCOM04539610824,282536,626SH SOLE 536,62600
AUDENTES THERAPEUTICS INCCOM05070R10424,416781,309SH SOLE 781,30900
AVADEL PHARMACEUTICALS PLC SPONSORED ADR05337M10419,6132,391,841SH SOLE 2,391,84100
AVEO PHARMACEUTICALS INCCOM0535881098,2532,958,116SH SOLE 2,958,11600
AVEXIS INCCOM05366U10053,137480,141SH SOLE 480,14100
AZURRX BIOPHARMA INCCOM05502L105841227,272SH SOLE 227,27200
BEIGENE LTDSPONSORED ADR07725L1025575,700SH SOLE 5,70000
BIOHAVEN PHARMACTL HLDG CO L COMG111961057,045261,134SH SOLE 261,13400
BLUEBIRD BIO INCCOM09609G1002,56514,400SH SOLE 14,40000
BLUEPRINT MEDICINES CORPCOM09627Y10986,0001,140,434SH SOLE 1,140,43400
BRAINSTORM CELL THERAPEUTICS COM NEW10501E2011,568400,000SH SOLE 400,00000
CAPITAL SR LIVING CORPCOM1404751049,176680,173SH SOLE 680,17300
CAPRICOR THERAPEUTICS INCCOM14070B10164,000SH SOLE 4,00000
CAREDX INCCOM14167L1037,6391,040,676SH SOLE 1,040,67600
CASI PHARMACEUTICALS INCCOM14757U10927283,682SH SOLE 83,68200
CELLECTIS SASPONSORED ADS15117K10310,203350,000SH SOLE 350,00000
CENTENE CORP DELCOM15135B1016766,699SH SOLE 6,69900
CHAMPIONS ONCOLOGY INCCOM NEW15870P3071,499386,540SH SOLE 386,54000
CLEARSIDE BIOMEDICAL INCCOM1850631044,341620,181SH SOLE 620,18100
CORBUS PHARMACEUTICALS HLDGSCOM21833P1031,420200,000SH SOLE 200,00000
CORIUM INTL INCCOM21887L10756,1915,847,133SH SOLE 5,847,13300
CURIS INCCOM231269101666951,201SH SOLE 951,20100
CUTERA INCCOM23210910854311,981SH SOLE 11,98100
CYMABAY THERAPEUTICS INCCOM23257D10324,7102,685,882SH SOLE 2,685,88200
CYTOMX THERAPEUTICS INCCOM23284F10552,5712,490,381SH SOLE 2,490,38100
DBV TECHNOLOGIES SA SPONSORED ADR23306J10124,075978,619SH SOLE 978,61900
DECIPHERA PHARMACEUTICALS INCOM24344T1012,324102,500SH SOLE 102,50000
DOVA PHARMACEUTICALS INCCOM25985T10252,0991,809,015SH SOLE 1,809,01500
EIGER BIOPHARMACEUTICALS INCCOM28249U1052,199157,679SH SOLE 157,67900
ENDOCYTE INCCOM29269A1026,2131,451,700SH SOLE 1,451,70000
ESPERION THERAPEUTICS INC NECOM29664W10570910,769SH SOLE 10,76900
EVOLENT HEALTH INCCL A 30050B10161550,000SH SOLE 50,00000
EXELIXIS SHARES INC COM30161Q1041,40946,361SH SOLE 46,36100
FERRARI NVCOMN3167Y1036506,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES NSHSN317381021,10662,000SH SOLE 62,00000
FLEXION THERAPEUTICS INCCOM33938J1067,712307,989SH SOLE 307,98900
FOAMIX PHARMACEUTICALS LTDSHSM461351056,7151,117,324SH SOLE 1,117,32400
GALAPAGOS NVSPON ADR36315X10119,343206,305SH SOLE 206,30500
GLOBAL BLOOD THERAPEUTICS INCOM37890U108192,3844,889,066SH SOLE 4,889,06600
GLOBUS MED INC CL A 3795772084,648113,100SH SOLE 113,10000
HISTOGENICS CORP COM43358V1093,6441,777,777SH SOLE 1,777,77700
HUMANA INCCOM44485910219,22577,500SH SOLE 77,50000
HUTCHISON CHINA MEDITECH LTDSPONSORED ADR44842L10339410,000SH SOLE 10,00000
IGNYTA INCCOM45173110380730,211SH SOLE 30,21100
INVACARE CORPCOM4612031013,370200,000SH SOLE 200,00000
INTUITIVE SURGICAL INCCOM NEW46120E60225,75970,585SH SOLE 70,58500
INVITAE CORPCOM46185L10318,2002,004,500SH SOLE 2,004,50000
IOVANCE BIOTHERAPEUTICS INC COM46226010038,2084,776,114SH SOLE 4,776,11400
IRHYTHM TECHNOLOGIES INCCOM45005610623,954427,371SH SOLE 427,37100
JUNO THERAPEUTICS INC COM48205A10993300,000SHCallSOLE 300,00000
KADMON HLDGS INCCOM48283N10618,7725,185,847SH SOLE 5,185,84700
KERYX BIOPHARMACEUTICALS INCCOM49251510138883,386SH SOLE 83,38600
LA JOLLA PHARMACEUTICAL COCOM PAR $.0001 2503459604109,0463,388,611SH SOLE 3,388,61100
LANTHEUS HLDGS INCCOM5165441031,09953,763SH SOLE 53,76300
MADRIGAL PHARMACEUTICALS INCCOM55886810517,338188,893SH SOLE 188,89300
MARINUS PHARMACEUTICALS INCCOM56854Q1017,407907,732SH SOLE 907,73200
MERIT MED SYS INC COM58988910437,757874,013SH SOLE 874,01300
MIRATI THERAPEUTICS INCCOM60468T10553129,091SH SOLE 29,09100
MOLECULAR TEMPLATES INC COM6085501097,255724,133SH SOLE 724,13300
MYOKARDIA INCCOM62857M10529,922710,726SH SOLE 710,72600
NEOS THERAPEUTICS INCCOM64052L1063,060300,000SH SOLE 300,00000
NEPTUNE TECHNOLOGIES BIORESOCOM64077P10819,7628,374,015SH SOLE 8,374,01500
NEUROCRINE BIOSCIENCES COM64125C109399,7125,151,589SH SOLE 5,151,58900
NEWLINK GENETICS CORPCOM6515111073,650450,000SH SOLE 450,00000
ODONATE THERAPEUTICS INCCOM6760791063,750150,000SH SOLE 150,00000
ONCOMED PHARMACEUTICALS INCCOM68234X10210,7452,620,897SH SOLE 2,620,89700
OXFORD IMMUNOTEC GLOBAL PLCORD SHSG6855A1036,990500,356SH SOLE 500,35600
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/071426VAK44211,000,000PRN SOLE 1,000,00000
PFENEX INCCOM7170711041,383519,773SH SOLE 519,77300
PROGENICS PHARMACEUTICALS INCOM74318710636861,850SH SOLE 61,85000
PROTEON THERAPEUTICS INCCOM74371L109635334,116SH SOLE 334,11600
PUMA BIOTECHNOLOGY INC COM74587V10755100,000SHCallSOLE 100,00000
PUMA BIOTECHNOLOGY INC COM74587V10769,573703,820SH SOLE 703,82000
QUANTERIX CORPCOM74766Q1013,637169,400SH SOLE 169,40000
QUOTIENT TECHNOLOGY INCCOMG7326810729,6836,033,020SH SOLE 6,033,02000
REGENERON PHARMACEUTICALSCOM75886F1077,51920,000SH SOLE 20,00000
REGENXBIO INCCOM75901B10747,2541,421,186SH SOLE 1,421,18600
RETROPHIN INCCOM76129910656,3102,672,525SH SOLE 2,672,52500
REVANCE THERAPEUTICS INCCOM76133010914,300400,000SH SOLE 400,00000
RHYTHM PHARMACEUTICALS INCCOM76243J10521,654745,135SH SOLE 745,13500
SELECTA BIOSCIENCES INCCOM8162121046,206632,712SH SOLE 632,71200
SENSEONICS HLDGS INCCOM81727U105306115,000SH SOLE 115,00000
SIERRA ONCOLOGY INCCOM82640U10718,6505,000,000SH SOLE 5,000,00000
SPDR S&P BIOTECH ETF SHS PUT 85 01/05/2018COM78464A870579600,000SHPutSOLE 600,00000
SPECTRUM PHARMACEUTICALS INCCOM84763A10860932,154SH SOLE 32,15400
STRONGBRIDGE BIOPHARMA PLCSHS USDG853471051,994275,000SH SOLE 275,00000
SUCAMPO PHARMACEUTICALS INCCL A86490910671940,062SH SOLE 40,06200
SYNLOGIC INCCOM87166L1006,658686,352SH SOLE 686,35200
TELEFLEX INCCOM87936910631,326125,900SH SOLE 125,90000
TESARO INCCOM88156910710,721129,372SH SOLE 129,37200
UNIQURE NVSHSN9006410120,5291,047,950SH SOLE 1,047,95000
UROGEN PHARMA LTDCOMM960881057,405199,014SH SOLE 199,01400
VALEANT PHARMACEUTICALS INTLCOM91911K10262530,092SH SOLE 30,09200
VBI VACCINES INCCOM NEW91822J10341,2739,665,843SH SOLE 9,665,84300
VERONA PHARMA PLCSPONSORED ADR9250501062,384200,000SH SOLE 200,00000
VERSARTIS INCCOM92529L1023,2731,488,160SH SOLE 1,488,16000
VERTEX PHARMACEUTICALS INCCOM92532F10020,774138,626SH SOLE 138,62600
VICAL INC COM NEW9256022032,0911,142,858SH SOLE 1,142,85800
VIEWRAY INCCOM92672L10746350,000SH SOLE 50,00000
VOCERA COMMUNICATIONS INCCOM92857F1071,06335,169SH SOLE 35,16900
WAVE LIFE SCIENCES LTDSHSY9530810523,264662,798SH SOLE 662,79800
XENCOR INCCOM98401F10528,7831,313,095SH SOLE 1,313,09500
ZAI LAB LTDADR98887Q1043,715175,000SH SOLE 175,00000
ZIMMER BIOMET HLDGS INCCOM98956P10224,134200,000SH SOLE 200,00000
ZOGENIX INCCOM NEW98978L204160,7993,970,357SH SOLE 3,970,35700
ZOSANO PHARMA CORPCOM98979H103260500,000SH SOLE 500,00000
ZYMEWORKS SHARESCOM98985W1025,549777,497SH SOLE 777,49700