The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
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COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INC *W EXP 12/24/20100289Y11515,8461,259,636SH SOLE 1,259,63600
ABEONA THERAPEUTICS INC COM00289Y1071,993116,900SH SOLE 116,90000
ABIOMED INCCOM0036541008,72251,729SH SOLE 51,72900
ACASTI PHARMA INCCL A NEW 00430K402267186,559SH SOLE 186,55900
ACCELERON PHARMA INCCOM00434H10860,3191,616,259SH SOLE 1,616,25900
ACELRX PHARMACEUTICALS INCCOM00444T1005,7251,244,608SH SOLE 1,244,60800
ACHAOGEN INCCOM00444910443927,551SH SOLE 27,55100
ADMA BIOLOGICS INCCOM0008991042,221721,102SH SOLE 721,10200
AFFIMED N VCOMN010451081,503668,214SH SOLE 668,21400
AKEBIA THERAPEUTICS INCCOM00972D10532,0621,630,000SH SOLE 1,630,00000
ALBIREO PHARMA INCCOM01345P10617,703845,000SH SOLE 845,00000
ALDEYRA THERAPEUTICS INCCOM01438T10622,2153,085,458SH SOLE 3,085,45800
ALIGN TECHNOLOGY INCCOM0162551016423,448SH SOLE 3,44800
ALLIQUA BIOMEDICAL INCCOM NEW01962120015,4584,233,951SH SOLE 4,233,95100
ALNYLAM PHARMACEUTICALS COM02043Q107210,1671,788,802SH SOLE 1,788,80200
ALNYLAM PHARMACEUTICALS INC COM02043Q1072,315100,000SHCallSOLE 100,00000
ALNYLAM PHARMACEUTICALS INCCOM02043Q10745420,000SHPutSOLE 420,00000
AMICUS THERAPEUTICS INCCOM03152W109269,76017,888,597SH SOLE 17,888,59700
ANAPTYSBIO INCCOM03272410634,330982,269SH SOLE 982,26900
ANI PHARMACEUTICALS NOTE 3.00% 12/000182CAA18,1197,500,000PRN SOLE 7,500,00000
ANTARES PHARMA INCCOM03664210614,1074,353,897SH SOLE 4,353,89700
ARDELYX INCCOM0396971077,5731,352,391SH SOLE 1,352,39100
ARGENX SESPONSORED ADR04016X10110,098450,000SH SOLE 450,00000
ASSEMBLY BIOSCIENCES INCCOM04539610815,429441,833SH SOLE 441,83300
ATARA BIOTHERAPEUTICS INC COM04651310758135,106SH  SOLE 35,10600
ATHENAHEALTH SHARESCOM04685W1038,70570,000SH SOLE 70,00000
AUDENTES THERAPEUTICS INCCOM05070R10421,885781,309SH SOLE 781,30900
AVADEL PHARMACEUTICALS PLC SPONSORED ADR05337M10416,2651,549,005SH SOLE 1,549,00500
AVEO PHARMACEUTICALS INCCOM05358810912,5553,415,116SH SOLE 3,415,11600
AVEXIS INCCOM05366U10064,923671,181SH SOLE 671,18100
AZURRX BIOPHARMA INCCOM05502L105907227,272SH SOLE 227,27200
BEIGENE LTDSPONSORED ADR07725L1025905,700SH SOLE 5,70000
BIOHAVEN PHARMACTL HLDG CO LCOMG1119610511,443306,134SH SOLE 306,13400
BLUEPRINT MEDICINES CORPCOM09627Y10929,586424,661SH SOLE 424,66100
BRAINSTORM CELL THERAPEUTICSCOM NEW10501E2011,648400,000SH SOLE 400,00000
CAPITAL SR LIVING CORPCOM1404751047,031560,173SH SOLE 560,17300
CENTENE CORP DELCOM15135B1017487,726SH SOLE 7,72600
CHAMPIONS ONCOLOGY INCCOM15870P3071,418386,540SH SOLE 386,54000
CLEARSIDE BIOMEDICAL INCCOM1850631045,147620,181SH SOLE 620,18100
CLEMENTIA PHARMACEUTICALS INCOM1855751076,291352,250SH SOLE 352,25000
CORBUS PHARMACEUTICALS HLDGSCOM21833P1032,964414,684SH SOLE 414,68400
CORIUM INTL INC COM21887L10764,7865,847,133SH SOLE 5,847,13300
CURIS INCCOM2312691011,417951,201SH SOLE 951,20100
CUTERA INCCOM23210910849511,981SH SOLE 11,98100
CYMABAY THERAPEUTICS INCCOM23257D10318,9482,350,882SH SOLE 2,350,88200
CYTOMX THERAPEUTICS INCCOM23284F10525,2631,390,381SH SOLE 1,390,38100
DBV TECHNOLOGIES S A SPONSORED ADR23306J10124,463576,419SH SOLE 576,41900
DBV TECHNOLOGIES S ASPONSORED ADR23306J1012,808550,000SHPutSOLE 550,00000
DECIPHERA PHARMACEUTICALS INCOM24344T1011,946102,500SH SOLE 102,50000
DOVA PHARMACEUTICALS INC COM25985T10242,5871,754,015SH SOLE 1,754,01500
EIGER BIOPHARMACEUTICALS INCCOM28249U1051,734157,679SH SOLE 157,67900
ESPERION THERAPEUTICS INC NECOM29664W10554010,769SH SOLE 10,76900
EVOLENT HEALTH INCCL A 30050B10115,130850,000SH SOLE 850,00000
EXACT SCIENCES CORPCOM30063P1056,382135,444SH SOLE 135,44400
EXELIXIS INCCOM30161Q1041,12346,361SH SOLE 46,36100
FERRARI N VCOMN3167Y1036856,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES NSHRSN317381021,11062,000SH SOLE 62,00000
FIBROGEN INCCOM31572Q8084628,593SH SOLE 8,59300
FOAMIX PHARMACEUTICALS LTDSHSM461351056,2011,117,324SH SOLE 1,117,32400
GALAPAGOS N V SPON ADR36315X10121,002206,405SH SOLE 206,40500
GILEAD SCIENCES INCCOM3755581033,24140,000SH SOLE 40,00000
GLOBAL BLOOD THERAPEUTICS INCOM37890U108132,3994,264,066SH SOLE 4,264,06600
GW PHARMACEUTICALS PLCADS36197T1033,73136,763SH SOLE 36,76300
HERON THERAPEUTICS INCCOM4277461025,329330,000SH SOLE 330,00000
HESKA CORPCOM RESTRC NEW 42805E3066437,300SH SOLE 7,30000
HISTOGENICS CORP COM43358V1093,5191,777,777SH SOLE 1,777,77700
HUMANA INCCOM44485910224,363100,000SH SOLE 100,00000
HUTCHISON CHINA MEDITECH LTDSPONSORED ADR44842L10327310,000SH SOLE 10,00000
IMMUNOGEN INCCOM45253H10153670,126SH SOLE 70,12600
INCYTE CORP COM45337C10235100,000SHCallSOLE 100,00000
INCYTE CORP COM45337C1026565,619SH SOLE 5,61900
INOVALON HLDGS INCCOM CL A45781D10151130,000SH SOLE 30,00000
INTERCEPT PHARMACEUTICALS INCOM45845P1085,22490,000SH SOLE 90,00000
INTERCEPT PHARMACEUTICALS INCOM45845P108283250,000SHCallSOLE 250,00000
INTRA CELLULAR THERAPIES INCCOM46116X10114,667929,460SH SOLE 929,46000
INVACARE CORP COM4612031013,950200,000SH SOLE 200,00000
INTUITIVE SURGICAL INCCOM NEW46120E60226,35125,195SH SOLE 25,19500
INVITAE CORPCOM46185L10317,6571,884,500SH SOLE 1,884,50000
IONIS PHARMACEUTICALS INC COM4622221002460,000SHCallSOLE 60,00000
IOVANCE BIOTHERAPEUTICS INCCOM46226010036,6274,726,114SH SOLE 4,726,11400
IRHYTHM TECHNOLOGIES INCCOM45005610619,335372,671SH SOLE 372,67100
KADMON HLDGS INCCOM48283N10617,3725,185,847SH SOLE 5,185,84700
KERYX BIOPHARMACEUTICALS INCCOM49251510159283,386SH SOLE 83,38600
LA JOLLA PHARMACEUTICAL COCOM PAR.0001 250345960475,0212,157,011SH SOLE 2,157,01100
LANTHEUS HLDGS INCCOM51654410395753,763SH SOLE 53,76300
MARINUS PHARMACEUTICALS COM56854Q1018,5271,452,700SH SOLE 1,452,70000
MERIT MEDICAL SYS INCCOM5898891044,235100,000SH SOLE 100,00000
MGC DIAGNOSTICS CORPCOM5527681032,261252,327SH SOLE 252,32700
MOLECULAR TEMPLATES INCCOM6085501094,231724,133SH SOLE 724,13300
MOLINA HEALTHCARE INC COM60855R10034550,000SHCallSOLE 50,00000
MYOKARDIA INCCOM62857M10523,598550,717SH SOLE 550,71700
NABRIVA THERAPEUTICS PLCSHSG6363710543152,570SH SOLE 52,57000
NEPTUNE TECHNOLOGIES BIORESOCOM64077P1084,1136,519,634SH SOLE 6,519,63400
NEUROCRINE BIOSCIENCES INCCOM64125C109293,6294,791,589SH SOLE 4,791,58900
NEWLINK GENETICS CORPCOM6515111074,581450,000SH SOLE 450,00000
NUCANA PLSSPONSORED ADR67022C1063,674200,000SH SOLE 200,00000
NXSTAGE MEDICAL INCCOM67072V10334,9011,264,523SH SOLE 1,264,52300
OCERA THERAPEUTICS INCCOM67552A1082,3242,038,880SH SOLE 2,038,88000
ONCOMED PHARMACEUTICALS INCCOM68234X1024,6931,038,289SH SOLE 1,038,28900
ORASURE TECHNOLOGIES INCCOM68554V1081,23154,729SH SOLE 54,72900
OXFORD IMMUNOTEC GLOBAL PLC ORD SHSG6855A1037,818465,356SH SOLE 465,35600
PARATEK PHARMACEUTICALS INCCOM69937430253221,186SH SOLE 21,18600
PERNIX THERAPEUTICS HLDGS INDBCV 4.250% 4/071426VAK44201,000,000PRN SOLE 1,000,00000
PFENEX INCCOM7170711042,555845,973SH SOLE 845,97300
PORTOLA PHARMACEUTICALS INCCOM7370101084257,870SH SOLE 7,87000
PRA HEALTH SCIENCES INCCOM69354M1085667,427SH SOLE 7,42700
PROTEON THERAPEUTICS INCCOM74371L109668334,116SH SOLE 334,11600
PUMA BIOTECHNOLOGY INCCOM74587V107110,627923,820SH SOLE 923,82000
QUOTIENT TECHNOLOGY INCCOMG7326810718,3743,726,986SH SOLE 3,726,98600
REGENXBIO INCCOM75901B10747,4871,441,186SH SOLE 1,441,18600
REPLIGEN INCCOM7599161093,34987,400SH SOLE 87,40000
RETROPHIN INCCOM76129910666,8592,686,204SH SOLE 2,686,20400
SAGE THERAPEUTICS INCCOM78667J108178215,000SHCallSOLE 215,00000
SELECTA BIOSCIENCES INCCOM81621210421,2121,162,325SH SOLE 1,162,32500
SENSEONICS HOLDINGS INCCOM81727U10516050,000SH SOLE 50,00000
SERES THERAPEUTICS INCCOM81750R1022,165135,000SH SOLE 135,00000
SIERRA ONCOLOGY INCCOM82640U1075,6663,655,186SH SOLE 3,655,18600
SPARK THERAPEUTICS INCCOM84652J10316,049180,000SH SOLE 180,00000
SYNLOGIC INCCOM87166L10013,050686,352SH SOLE 686,35200
TELADOC INCCOM87918A10548514,641SH SOLE 14,64100
TELEFLEX INCCOM87936910613,35755,200SH SOLE 55,20000
TESARO INCCOM88156910750,175388,651SH SOLE 388,65100
UNIQURE NVSHSN900641019,9851,040,119SH SOLE 1,040,11900
UROGEN PHARMA LTDCOMM960881058,479269,014SH SOLE 269,01400
VANDA PHARMACEUTICALS INCCOM92165910864936,232SH SOLE 36,23200
VBI VACCINES INCCOM NEW91822J10325,2786,565,843SH SOLE 6,565,84300
VERONA PHARMA PLCSPONSORED ADR9250501063,070200,000SH SOLE 200,00000
VERSARTIS INCCOM92529L1024,6251,888,160SH SOLE 1,888,16000
VERTEX PHARMACEUTICALS INCCOM92532F10021,077138,626SH SOLE 138,62600
VIVEVE MEDICAL INC COM NEW92852W2042,551486,988SH SOLE 486,98800
VOYAGER THERAPEUTICS INCCOM92915B10671234,604SH SOLE 34,60400
WAVE LIFE SCIENCES LTDSHSY9530810513,980642,798SH SOLE 642,79800
XENCOR INCCOM98401F10529,6381,293,095SH SOLE 1,293,09500
XENON PHARMACEUTICALS INCCOM9842ON1051,486503,853SH SOLE 503,85300
ZAI LAB LTDADR98887Q1044,725175,000SH SOLE 175,00000
ZOGENIX INCCOM NEW98978L204128,6463,670,357SH SOLE 3,670,35700
ZOSANO PHARMA INCCOM98979H103412500,000SH SOLE 500,00000
ZYMEWORKS INCCOM98985W1025,832730,768SH SOLE 730,76800
ZYNERBA PHARMACEUTICALS INCCOM98986X1091,320130,700SH SOLE 130,70000