The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC *W EXP 12/24/201 00289Y115 4,285 1,259,636 SH   SOLE   1,259,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 2,706 422,873 SH   SOLE   422,873 0 0
ACASTI PHARMA INC COM 00430K402 247 186,559 SH   SOLE   186,559 0 0
ACCELERON PHARMA INC COM 00434H108 21,615 711,259 SH   SOLE   711,259 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 8,022 3,731,342 SH   SOLE   3,731,342 0 0
ACHAOGEN INC COM 004449104 599 27,551 SH   SOLE   27,551 0 0
ACORDA THERAPEUTICS INC COM 00484M106 626 31,786 SH   SOLE   31,786 0 0
ADAMIS PHARMACEUTICALS CORP COM NEW 00547W208 2,080 400,000 SH   SOLE   400,000 0 0
ADMA BIOLOGICS INC COM 000899104 2,769 721,102 SH   SOLE   721,102 0 0
AFFIMED N V COM N01045108 1,369 668,214 SH   SOLE   668,214 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 15,808 1,100,000 SH   SOLE   1,100,000 0 0
ALBIREO PHARMA INC COM 01345P106 17,407 845,000 SH   SOLE   845,000 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 13,417 2,885,458 SH   SOLE   2,885,458 0 0
ALLIQUA BIOMEDICAL INC COM NEW 019621200 1,566 4,233,951 SH   SOLE   4,233,951 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 146,181 1,832,761 SH   SOLE   1,832,761 0 0
AMICUS THERAPEUTICS INC COM 03152W109 174,178 17,296,672 SH   SOLE   17,296,672 0 0
ANAPTYSBIO INC COM 032724106 22,788 952,269 SH   SOLE   952,269 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 7,908 7,500,000 PRN   SOLE   7,500,000 0 0
ANI PHARMACEUTICALS INC COM 00182C103 5,869 125,399 SH   SOLE   125,399 0 0
ANTARES PHARMA INC COM 036642106 13,741 4,267,253 SH   SOLE   4,267,253 0 0
ARDELYX INC COM 039697107 9,233 1,810,581 SH   SOLE   1,810,581 0 0
ARGENX SE SPONSORED ADR 04016X101 9,544 450,000 SH   SOLE   450,000 0 0
ARNO THERAPEUTICS INC COM 042564203 208 4,177,577 SH   SOLE   4,177,577 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 1,372 847,458 SH   SOLE   847,458 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 9,124 441,833 SH   SOLE   441,833 0 0
AUDENTES THERAPEUTICS INC COM 05070R104 13,534 707,500 SH   SOLE   707,500 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 15,763 1,429,114 SH   SOLE   1,429,114 0 0
AVEO PHARMACEUTICALS INC COM 053588109 13,343 6,010,660 SH   SOLE   6,010,660 0 0
AVEXIS INC COM 05366U100 22,280 271,181 SH   SOLE   271,181 0 0
AXOVANT SCIENCES LTD COM G0750W104 6,957 300,000 SH Call SOLE   0 0 0
AXOVANT SCIENCES LTD COM G0750W104 13,281 572,700 SH   SOLE   572,700 0 0
AZURRX BIOPHARMA INC COM 05502L105 916 227,272 SH   SOLE   227,272 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 3,000 120,000 SH   SOLE   120,000 0 0
BLUEBIRD BIO INC COM 09609G100 2,101 20,000 SH   SOLE   20,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 22,530 444,661 SH   SOLE   444,661 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 1,660 400,000 SH   SOLE   400,000 0 0
CAPITAL SR LIVING CORP COM 140475104 8,064 530,173 SH   SOLE   530,173 0 0
CARA THERAPEUTICS INC COM 140755109 1,539 100,000 SH Call SOLE   0 0 0
CENTENE CORP DEL COM 15135B101 617 7,726 SH   SOLE   7,726 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307 943 366,973 SH   SOLE   366,973 0 0
CIDARA THERAPEUTICS INC COM 171757107 465 62,110 SH   SOLE   62,110 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 5,649 620,181 SH   SOLE   620,181 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 7,764 1,232,500 SH   SOLE   1,232,500 0 0
CORIUM INTL INC COM 21887L107 43,620 5,847,133 SH   SOLE   5,847,133 0 0
CURIS INC COM 231269101 1,798 951,201 SH   SOLE   951,201 0 0
CUTERA INC COM 232109108 310 11,981 SH   SOLE   11,981 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 21,550 1,390,381 SH   SOLE   1,390,381 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 21,131 591,765 SH   SOLE   591,765 0 0
DIPLOMAT PHARMACY INC COM 25456K101 454 30,658 SH   SOLE   30,658 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 38,037 1,706,499 SH   SOLE   1,706,499 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 7,889 100,000 SH   SOLE   100,000 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 719 6,088 SH   SOLE   6,088 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,245 157,679 SH   SOLE   157,679 0 0
EVOLENT HEALTH INC CL A 30050B101 27,234 1,074,327 SH   SOLE   1,074,327 0 0
EXACT SCIENCES CORP COM 30063P105 3,537 100,000 SH   SOLE   100,000 0 0
EXELIXIS SHARES COM 30161Q104 1,142 46,361 SH   SOLE   46,361 0 0
FERRARI N V COM N3167Y103 533 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31738102 659 62,000 SH   SOLE   62,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 5,184 1,117,324 SH   SOLE   1,117,324 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 3,959 194,718 SH   SOLE   194,718 0 0
GALAPAGOS NV SPON ADR 36315X101 17,325 226,405 SH   SOLE   226,405 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 107,592 3,933,927 SH   SOLE   3,933,927 0 0
HESKA CORP COM RESTRC NEW 42805E306 745 7,300 SH   SOLE   7,300 0 0
HISTOGENICS CORP COM 43358V109 3,182 1,777,777 SH   SOLE   1,777,777 0 0
HILL ROM HLDGS INC COM 431475102 631 7,930 SH   SOLE   7,930 0 0
HUMANA INC COM 444859102 18,791 78,093 SH   SOLE   78,093 0 0
ICON PLC SHS G4705A100 507 5,187 SH   SOLE   5,187 0 0
INC RESH HLDGS INC CL A 45329R109 499 8,532 SH   SOLE   8,532 0 0
INCYTE CORP COM 45337C102 707 5,619 SH   SOLE   5,619 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 19,357 20,695 SH   SOLE   20,695 0 0
INVITAE CORP COM 46185L103 6,209 649,500 SH   SOLE   649,500 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 32,068 4,363,114 SH   SOLE   4,363,114 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 12,019 282,857 SH   SOLE   282,857 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 13,306 85,572 SH   SOLE   85,572 0 0
KADMON HLDGS INC COM 48283N106 20,172 5,185,847 SH   SOLE   5,185,847 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 64,214 2,157,011 SH   SOLE   2,157,011 0 0
LANTHEUS HLDGS INC COM 516544103 949 53,763 SH   SOLE   53,763 0 0
LHC GROUP INC COM 50187A107 728 10,730 SH   SOLE   10,730 0 0
MGC DIAGNOSTICS CORP COM 552768103 2,140 252,327 SH   SOLE   252,327 0 0
MOLINA HEALTHCARE INC COM 60855R100 563 8,140 SH   SOLE   8,140 0 0
MYOKARDIA INC COM 62857M105 14,492 553,154 SH   SOLE   553,154 0 0
NEPTUNE TECHNOLOGIES BIORESO COM 64077P108 3,801 6,519,634 SH   SOLE   6,519,634 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 164,569 3,577,589 SH   SOLE   3,577,589 0 0
NXSTAGE MEDICAL INC COM 67072V103 38,997 1,555,523 SH   SOLE   1,555,523 0 0
OCERA THERAPEUTICS INC COM 67552A108 2,365 2,038,880 SH   SOLE   2,038,880 0 0
ONCOBIOLOGICS INC W EXP 02/18/201 68235M113 80 462,500 SH   SOLE   462,500 0 0
ONCOBIOLOGICS INC *W EXP 05/18/201 68235M121 42 462,500 SH   SOLE   462,500 0 0
ONCOBIOLOGICS INC COM 68235M105 837 837,886 SH   SOLE   837,886 0 0
ORASURE TECHNOLOGIES INC COM 68554V108 945 54,729 SH   SOLE   54,729 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 741 44,106 SH   SOLE   44,106 0 0
PEREGRINE PHARMACEUTICALS IN COM NEW 713661304 15 24,332 SH   SOLE   24,332 0 0
PERNIX THERAPEUTICS HLDGS IN DBCV 4.250% 4/0 71426VAK4 282 1,000,000 PRN   SOLE   1,000,000 0 0
PFENEX INC COM 717071104 3,392 845,973 SH   SOLE   845,973 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 442 7,870 SH   SOLE   7,870 0 0
PROTEON THERAPEUTICS INC COM 74371L109 518 334,116 SH   SOLE   334,116 0 0
PSIVIDA CORP COM 74440J101 1,966 1,149,556 SH   SOLE   1,149,556 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 64,092 733,320 SH   SOLE   733,320 0 0
QUOTIENT LTD SHS G73268107 26,010 3,714,486 SH   SOLE   3,714,486 0 0
RADIUS HEALTH INC COM NEW 750469207 9,046 200,000 SH Put SOLE   200,000 0 0
RADIUS HEALTH INC COM NEW 750469207 29,212 645,873 SH   SOLE   645,873 0 0
REGENXBIO INC COM 75901B107 27,080 1,371,186 SH   SOLE   1,371,186 0 0
RETROPHIN INC COM 761299106 51,816 2,672,309 SH   SOLE   2,672,309 0 0
SAGE THERAPEUTICS INC COM 78667J108 21,901 275,000 SH Call SOLE   0 0 0
SAREPTA THERAPEUTICS COM 803607100 36,743 1,089,961 SH   SOLE   1,089,961 0 0
SELECTA BIOSCIENCES INC COM 816212104 15,834 797,325 SH   SOLE   797,325 0 0
SIERRA ONCOLOGY INC COM 82640U107 4,277 3,655,186 SH   SOLE   3,655,186 0 0
TESARO INC COM 881569107 50,287 359,551 SH   SOLE   359,551 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 6,211 100,000 SH Call SOLE   0 0 0
UNIQURE NV SHS N90064101 6,748 1,090,119 SH   SOLE   1,090,119 0 0
UNITEDHEALTH GROUP INC COM 91324P102 5,281 28,480 SH   SOLE   28,480 0 0
UROGEN PHARMA LTD COM M96088105 4,858 269,014 SH   SOLE   269,014 0 0
VANDA PHARMACEUTICALS INC COM 921659108 591 36,232 SH   SOLE   36,232 0 0
VBI VACCINES IN COM NEW 91822J103 28,561 6,565,843 SH   SOLE   6,565,843 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 2,331 200,000 SH   SOLE   200,000 0 0
VERSARTIS INC COM 92529L102 76,907 4,407,317 SH   SOLE   4,407,317 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 35,742 277,352 SH   SOLE   277,352 0 0
VIVEVE MED INC COM NEW 92852W204 6,394 890,468 SH   SOLE   890,468 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 310 34,604 SH   SOLE   34,604 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 12,328 662,798 SH   SOLE   662,798 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 908 5,056 SH   SOLE   5,056 0 0
XENCOR INC COM 98401F105 27,297 1,293,095 SH   SOLE   1,293,095 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,280 723,853 SH   SOLE   723,853 0 0
ZOGENIX INC COM NEW 98978L204 50,000 3,448,302 SH   SOLE   3,448,302 0 0
ZOSANO PHARMA CORP COM 98979H103 705 500,000 SH   SOLE   500,000 0 0
ZYMEWORKS INC COM 98985W102 6,101 730,768 SH   SOLE   730,768 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 10,164 100,000 SH Put SOLE   100,000 0 0