The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number:3235-0006
Expires:Oct 31, 2018
Estimated average burden
hours per response:23.8

COLUMN 1COLUMN 2COLUMN 3COLUMN 4COLUMN 5COLUMN 6COLUMN 7COLUMN 8
VALUESHRS ORSH/PUT/INVESTMENTOTHERVOTING AUTHORITY
NAME OF ISSUERTITLE OF CLASSCUSIP(x$1000)PRN AMTPRNCALLDISCRETIONMANAGERSOLESHAREDNONE
ABEONA THERAPEUTICS INC*W EXP 12/24/20100289Y1154,2851,259,636SH SOLE 1,259,63600
ABEONA THERAPEUTICS INCCOM00289Y1072,706422,873SH SOLE 422,87300
ACASTI PHARMA INCCOM00430K402247186,559SH SOLE 186,55900
ACCELERON PHARMA INCCOM00434H10821,615711,259SH SOLE 711,25900
ACELRX PHARMACEUTICALS INCCOM00444T1008,0223,731,342SH SOLE 3,731,34200
ACHAOGEN INCCOM00444910459927,551SH SOLE 27,55100
ACORDA THERAPEUTICS INCCOM00484M10662631,786SH SOLE 31,78600
ADAMIS PHARMACEUTICALS CORPCOM NEW00547W2082,080400,000SH SOLE 400,00000
ADMA BIOLOGICS INCCOM0008991042,769721,102SH SOLE 721,10200
AFFIMED N VCOMN010451081,369668,214SH SOLE 668,21400
AKEBIA THERAPEUTICS INCCOM00972D10515,8081,100,000SH SOLE 1,100,00000
ALBIREO PHARMA INCCOM01345P10617,407845,000SH SOLE 845,00000
ALDEYRA THERAPEUTICS INCCOM01438T10613,4172,885,458SH SOLE 2,885,45800
ALLIQUA BIOMEDICAL INCCOM NEW0196212001,5664,233,951SH SOLE 4,233,95100
ALNYLAM PHARMACEUTICALS INCCOM02043Q107146,1811,832,761SH SOLE 1,832,76100
AMICUS THERAPEUTICS INCCOM03152W109174,17817,296,672SH SOLE 17,296,67200
ANAPTYSBIO INCCOM03272410622,788952,269SH SOLE 952,26900
ANI PHARMACEUTICALS INCNOTE 3.000%12/000182CAA17,9087,500,000PRN SOLE 7,500,00000
ANI PHARMACEUTICALS INCCOM00182C1035,869125,399SH SOLE 125,39900
ANTARES PHARMA INCCOM03664210613,7414,267,253SH SOLE 4,267,25300
ARDELYX INCCOM0396971079,2331,810,581SH SOLE 1,810,58100
ARGENX SESPONSORED ADR04016X1019,544450,000SH SOLE 450,00000
ARNO THERAPEUTICS INCCOM0425642032084,177,577SH SOLE 4,177,57700
ARROWHEAD PHARMACEUTICALS INCOM04280A1001,372847,458SH SOLE 847,45800
ASSEMBLY BIOSCIENCES INCCOM0453961089,124441,833SH SOLE 441,83300
AUDENTES THERAPEUTICS INCCOM05070R10413,534707,500SH SOLE 707,50000
AVADEL PHARMACEUTICALS PLCSPONSORED ADR05337M10415,7631,429,114SH SOLE 1,429,11400
AVEO PHARMACEUTICALS INCCOM05358810913,3436,010,660SH SOLE 6,010,66000
AVEXIS INCCOM05366U10022,280271,181SH SOLE 271,18100
AXOVANT SCIENCES LTDCOMG0750W1046,957300,000SHCallSOLE 000
AXOVANT SCIENCES LTDCOMG0750W10413,281572,700SH SOLE 572,70000
AZURRX BIOPHARMA INCCOM05502L105916227,272SH SOLE 227,27200
BIOHAVEN PHARMACTL HLDG CO LCOMG111961053,000120,000SH SOLE 120,00000
BLUEBIRD BIO INCCOM09609G1002,10120,000SH SOLE 20,00000
BLUEPRINT MEDICINES CORPCOM09627Y10922,530444,661SH SOLE 444,66100
BRAINSTORM CELL THERAPEUTICSCOM NEW10501E2011,660400,000SH SOLE 400,00000
CAPITAL SR LIVING CORPCOM1404751048,064530,173SH SOLE 530,17300
CARA THERAPEUTICS INCCOM1407551091,539100,000SHCallSOLE 000
CENTENE CORP DELCOM15135B1016177,726SH SOLE 7,72600
CHAMPIONS ONCOLOGY INCCOM NEW15870P307943366,973SH SOLE 366,97300
CIDARA THERAPEUTICS INCCOM17175710746562,110SH SOLE 62,11000
CLEARSIDE BIOMEDICAL INCCOM1850631045,649620,181SH SOLE 620,18100
CORBUS PHARMACEUTICALS HLDGSCOM21833P1037,7641,232,500SH SOLE 1,232,50000
CORIUM INTL INCCOM21887L10743,6205,847,133SH SOLE 5,847,13300
CURIS INCCOM2312691011,798951,201SH SOLE 951,20100
CUTERA INCCOM23210910831011,981SH SOLE 11,98100
CYTOMX THERAPEUTICS INCCOM23284F10521,5501,390,381SH SOLE 1,390,38100
DBV TECHNOLOGIES S ASPONSORED ADR23306J10121,131591,765SH SOLE 591,76500
DIPLOMAT PHARMACY INCCOM25456K10145430,658SH SOLE 30,65800
DOVA PHARMACEUTICALS INCCOM25985T10238,0371,706,499SH SOLE 1,706,49900
EAGLE PHARMACEUTICALS INCCOM2697961087,889100,000SH SOLE 100,00000
EDWARDS LIFESCIENCES CORPCOM28176E1087196,088SH SOLE 6,08800
EIGER BIOPHARMACEUTICALS INCCOM28249U1051,245157,679SH SOLE 157,67900
EVOLENT HEALTH INCCL A30050B10127,2341,074,327SH SOLE 1,074,32700
EXACT SCIENCES CORPCOM30063P1053,537100,000SH SOLE 100,00000
EXELIXIS SHARESCOM30161Q1041,14246,361SH SOLE 46,36100
FERRARI N VCOMN3167Y1035336,200SH SOLE 6,20000
FIAT CHRYSLER AUTOMOBILES NSHSN3173810265962,000SH SOLE 62,00000
FOAMIX PHARMACEUTICALS LTDSHSM461351055,1841,117,324SH SOLE 1,117,32400
FORWARD PHARMA A/SSPONSORED ADR34986J1053,959194,718SH SOLE 194,71800
GALAPAGOS NVSPON ADR36315X10117,325226,405SH SOLE 226,40500
GLOBAL BLOOD THERAPEUTICS INCOM37890U108107,5923,933,927SH SOLE 3,933,92700
HESKA CORPCOM RESTRC NEW42805E3067457,300SH SOLE 7,30000
HISTOGENICS CORPCOM43358V1093,1821,777,777SH SOLE 1,777,77700
HILL ROM HLDGS INCCOM4314751026317,930SH SOLE 7,93000
HUMANA INCCOM44485910218,79178,093SH SOLE 78,09300
ICON PLCSHSG4705A1005075,187SH SOLE 5,18700
INC RESH HLDGS INCCL A45329R1094998,532SH SOLE 8,53200
INCYTE CORPCOM45337C1027075,619SH SOLE 5,61900
INTUITIVE SURGICAL INCCOM NEW46120E60219,35720,695SH SOLE 20,69500
INVITAE CORPCOM46185L1036,209649,500SH SOLE 649,50000
IOVANCE BIOTHERAPEUTICS INCCOM46226010032,0684,363,114SH  SOLE 4,363,11400
IRHYTHM TECHNOLOGIES INCCOM45005610612,019282,857SH SOLE 282,85700
JAZZ PHARMACEUTICALS PLCSHS USDG5087110513,30685,572SH SOLE 85,57200
KADMON HLDGS INCCOM48283N10620,1725,185,847SH SOLE 5,185,84700
LA JOLLA PHARMACEUTICAL COCOM PAR $.0001 250345960464,2142,157,011SH SOLE 2,157,01100
LANTHEUS HLDGS INCCOM51654410394953,763SH SOLE 53,76300
LHC GROUP INCCOM50187A10772810,730SH SOLE 10,73000
MGC DIAGNOSTICS CORPCOM5527681032,140252,327SH SOLE 252,32700
MOLINA HEALTHCARE INCCOM60855R1005638,140SH SOLE 8,14000
MYOKARDIA INCCOM62857M10514,492553,154SH SOLE 553,15400
NEPTUNE TECHNOLOGIES BIORESOCOM64077P1083,8016,519,634SH SOLE 6,519,63400
NEUROCRINE BIOSCIENCES INCCOM64125C109164,5693,577,589SH SOLE 3,577,58900
NXSTAGE MEDICAL INCCOM67072V10338,9971,555,523SH SOLE 1,555,52300
OCERA THERAPEUTICS INCCOM67552A1082,3652,038,880SH SOLE 2,038,88000
ONCOBIOLOGICS INCW EXP 02/18/20168235M11380462,500SH SOLE 462,50000
ONCOBIOLOGICS INC*W EXP 05/18/20168235M12142462,500SH SOLE 462,50000
ONCOBIOLOGICS INCCOM68235M105837837,886SH SOLE 837,88600
ORASURE TECHNOLOGIES INCCOM68554V10894554,729SH SOLE 54,72900
OXFORD IMMUNOTEC GLOBAL PLCORD SHSG6855A10374144,106SH SOLE 44,10600
PEREGRINE PHARMACEUTICALS INCOM NEW7136613041524,332SH SOLE 24,33200
PERNIX THERAPEUTICS HLDGS INDBCV 4.250% 4/071426VAK42821,000,000PRN SOLE 1,000,00000
PFENEX INCCOM7170711043,392845,973SH SOLE 845,97300
PORTOLA PHARMACEUTICALS INCCOM7370101084427,870SH SOLE 7,87000
PROTEON THERAPEUTICS INCCOM74371L109518334,116SH SOLE 334,11600
PSIVIDA CORPCOM74440J1011,9661,149,556SH SOLE 1,149,55600
PUMA BIOTECHNOLOGY INCCOM74587V10764,092733,320SH SOLE 733,32000
QUOTIENT LTDSHSG7326810726,0103,714,486SH SOLE 3,714,48600
RADIUS HEALTH INCCOM NEW7504692079,046200,000SHPutSOLE 200,00000
RADIUS HEALTH INCCOM NEW75046920729,212645,873SH SOLE 645,87300
REGENXBIO INCCOM75901B10727,0801,371,186SH SOLE 1,371,18600
RETROPHIN INCCOM76129910651,8162,672,309SH SOLE 2,672,30900
SAGE THERAPEUTICS INCCOM78667J10821,901275,000SHCallSOLE 000
SAREPTA THERAPEUTICS COM80360710036,7431,089,961SH SOLE 1,089,96100
SELECTA BIOSCIENCES INCCOM81621210415,834797,325SH SOLE 797,32500
SIERRA ONCOLOGY INCCOM82640U1074,2773,655,186SH SOLE 3,655,18600
TESARO INCCOM88156910750,287359,551SH  SOLE 359,55100
ULTRAGENYX PHARMACEUTICAL INCOM90400D1086,211100,000SHCallSOLE 000
UNIQURE NVSHSN900641016,7481,090,119SH SOLE 1,090,11900
UNITEDHEALTH GROUP INCCOM91324P1025,28128,480SH SOLE 28,48000
UROGEN PHARMA LTDCOMM960881054,858269,014SH SOLE 269,01400
VANDA PHARMACEUTICALS INCCOM92165910859136,232SH SOLE 36,23200
VBI VACCINES INCOM NEW91822J10328,5616,565,843SH SOLE 6,565,84300
VERONA PHARMA PLCSPONSORED ADS9250501062,331200,000SH SOLE 200,00000
VERSARTIS INCCOM92529L10276,9074,407,317SH SOLE 4,407,31700
VERTEX PHARMACEUTICALS INCCOM92532F10035,742277,352SH SOLE 277,35200
VIVEVE MED INCCOM NEW92852W2046,394890,468SH SOLE 890,46800
VOYAGER THERAPEUTICS INCCOM92915B10631034,604SH SOLE 34,60400
WAVE LIFE SCIENCES LTDSHSY9530810512,328662,798SH SOLE 662,79800
WELLCARE HEALTH PLANS INCCOM94946T1069085,056SH SOLE 5,05600
XENCOR INCCOM98401F10527,2971,293,095SH SOLE 1,293,09500
XENON PHARMACEUTICALS INCCOM98420N1052,280723,853SH SOLE 723,85300
ZOGENIX INCCOM NEW98978L20450,0003,448,302SH SOLE 3,448,30200
ZOSANO PHARMA CORPCOM98979H103705500,000SH SOLE 500,00000
ZYMEWORKS INCCOM98985W1026,101730,768SH SOLE 730,76800
ZYNERBA PHARMACEUTICALS INCCOM98986X10910,164100,000SHPutSOLE 100,00000