SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 5 Common Stock, par value $0.01 per share 06/30/2025 0001178879 Amicus Therapeutics, Inc. 03152W109 47 Hulfish Street Princeton NJ 08542 Rule 13d-1(c) Perceptive Advisors LLC DE 0 7412830 0 7412830 7412830 N 2.4 IA Joseph Edelman X1 0 7412830 0 7412830 7412830 N 2.4 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 7412830 0 7412830 7412830 N 2.4 CO Amicus Therapeutics, Inc. 47 Hulfish Street, Princeton, NJ 08542 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.01 per share (the "Common Stock") of Amicus Therapeutics, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 308,239,374 shares of Common Stock outstanding as of July 25, 2025, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on July 31, 2025. The Master Fund directly holds 7,412,830 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own such shares. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own such shares. Perceptive Advisors: 2.4% Mr. Edelman: 2.4% Master Fund: 2.4% Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 7,412,830 Mr. Edelman: 7,412,830 Master Fund: 7,412,830 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 7,412,830 Mr. Edelman: 7,412,830 Master Fund: 7,412,830 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 08/14/2025 Joseph Edelman /s/ Joseph Edelman 08/14/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 08/14/2025