SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 1 Common Stock, $0.0001 par value per share 03/31/2025 0001674632 Beta Bionics, Inc. 08659B102 11 Hughes Irvine CA 92618 Rule 13d-1(c) Perceptive Advisors LLC DE 0 1593608 0 1593608 1593608 N 3.68 IA Joseph Edelman X1 0 1593608 0 1593608 1593608 N 3.68 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 1593608 0 1593608 1593608 N 3.68 CO Beta Bionics, Inc. 11 Hughes, Irvine, CA 92618 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.0001 per share (the "Common Stock") of Beta Bionics, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 43,348,840 shares of Common Stock outstanding as of March 1, 2025, as reported in the Issuer's Annual Report on Form 10-K/A filed with the Securities and Exchange Commission on March 28, 2025. The Master Fund directly holds, and directly held as of March 31, 2025, 1,593,608 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own such shares. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own such shares. This Amendment No. 1 to Schedule 13G restates the holdings of the Master Fund as of the date hereof, and as of the date reported on the Reporting Persons' initial filing on Schedule 13G. Perceptive Advisors: 3.68% Mr. Edelman: 3.68% Master Fund: 3.68% Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,593,608 Mr. Edelman: 1,593,608 Master Fund: 1,593,608 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,593,608 Mr. Edelman: 1,593,608 Master Fund: 1,593,608 N Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 08/07/2025 Joseph Edelman /s/ Joseph Edelman 08/07/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 08/07/2025