SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 1 Common Shares, without par value 03/31/2025 0001827401 Bright Minds Biosciences Inc. 10919W405 19 Vestry Street New York NY 10013 Rule 13d-1(c) Perceptive Advisors LLC DE 0 444649 0 444649 444649 N 6.3 IA Joseph Edelman X1 0 444649 0 444649 444649 N 6.3 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 444649 0 444649 444649 N 6.3 CO Bright Minds Biosciences Inc. 19 Vestry Street, New York, NY 10013 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to Common Shares without par value (the "Common Shares"), of Bright Minds Biosciences Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 7,043,989 Common Shares outstanding as of January 31, 2025, as reported in the Issuer's Prospectus filed pursuant to Rule 424(b)(3) with the Securities and Exchange Commission on February 14, 2025. The Master Fund directly holds 444,649 Common Shares. Perceptive Advisors serves as the investment manager to the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors. Perceptive Advisors: 6.3% Mr. Edelman: 6.3% Master Fund: 6.3 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 444,649 Mr. Edelman: 444,649 Master Fund: 444,649 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 444,649 Mr. Edelman: 444,649 Master Fund: 444,649 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 05/15/2025 Joseph Edelman /s/ Joseph Edelman 05/15/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 05/15/2025