SCHEDULE 13G/A 0001224962 XXXXXXXX LIVE 2 Class A Common Stock, par value $0.001 per share 03/31/2025 0001855175 Contineum Therapeutics, Inc. 21217B100 3536 General Atomics Court Suite 200 San Diego CA 92121 Rule 13d-1(c) Perceptive Advisors LLC DE 0 1441249 0 1441249 1441249 N 7.5 IA Joseph Edelman X1 0 1441249 0 1441249 1441249 N 7.5 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 1441249 0 1441249 1441249 N 7.5 CO Contineum Therapeutics, Inc. 3565 General Atomics Court, Suite 200, San Diego, CA 92121 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Class A Common Stock, par value $0.001 per share (the "Common Stock") of Contineum Therapeutics, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 of the cover pages to this Schedule 13G. The ownership percentages reported are based on 19,142,377 shares of Common Stock outstanding as of March 14, 2025, as reported in the Issuer's Definitive Proxy Statement on Schedule 14A filed with the Securities and Exchange Commission on April 29, 2025. The Master Fund directly holds 1,441,249 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund and may be deemed to beneficially own such shares. Mr. Edelman is the managing member of Perceptive Advisors and may be deemed to beneficially own such shares. Perceptive Advisors: 7.5% Mr. Edelman: 7.5% Master Fund: 7.5 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,441,249 Mr. Edelman: 1,441,249 Master Fund: 1,441,249 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 1,441,249 Mr. Edelman: 1,441,249 Master Fund: 1,441,249 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 05/15/2025 Joseph Edelman /s/ Joseph Edelman 05/15/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 05/15/2025