SCHEDULE 13G/A 0001193125-24-273581 0001224962 XXXXXXXX LIVE 2 Common Stock, par value $0.000041666 per share 12/31/2024 0001425205 Iovance Biotherapeutics, Inc. 462260100 825 Industrial Road Suite 400 San Carlos CA 94070 Rule 13d-1(c) Perceptive Advisors LLC DE 0 22112266 0 22112266 22112266 N 7.3 IA Joseph Edelman X1 0 22112266 0 22112266 22112266 N 7.3 IN Perceptive Life Sciences Master Fund, Ltd. E9 0 22112266 0 22112266 22112266 N 7.3 CO Iovance Biotherapeutics, Inc. 825 Industrial Road, Suite 400, San Carlos, CA 94070 The names of the persons filing this report (collectively, the "Reporting Persons") with respect to shares of Common Stock, par value $0.00041666 per share (the "Common Stock") of Iovance Biotherapeutics, Inc. (the "Issuer") are: (i) Perceptive Advisors LLC ("Perceptive Advisors") (ii) Joseph Edelman ("Mr. Edelman") (iii) Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund") The address of the principal business office of each of the Reporting Persons is: 51 Astor Place, 10th Floor, New York, NY 10003 Perceptive Advisors is a Delaware limited liability company. Mr. Edelman is a United States citizen. The Master Fund is a Cayman Islands corporation. Y The information required by this item with respect to each Reporting Person is set forth in Rows 5 through 9 and 11 of the cover page to this Schedule 13G. The ownership percentages reported are based on 304,780,790 outstanding shares of Common Stock as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 7,2024. Neither Perceptive Advisors nor Mr. Edelman directly holds any shares of Common Stock. The Master Fund directly holds 22,112,266 shares of Common Stock. Perceptive Advisors serves as the investment manager to the Master Fund. Mr. Edelman is the managing member of Perceptive Advisors. Perceptive Advisors: 7.3% Mr. Edelman: 7.3% Master Fund: 7.3 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 22,112,266 Mr. Edelman: 22,112,266 Master Fund: 22,112,266 Perceptive Advisors: 0 Mr. Edelman: 0 Master Fund: 0 Perceptive Advisors: 22,112,266 Mr. Edelman: 22,112,266 Master Funds: 22,112,266 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Perceptive Advisors LLC /s/ Joseph Edelman 02/14/2025 Joseph Edelman /s/ Joseph Edelman 02/14/2025 Perceptive Life Sciences Master Fund, Ltd. /s/ Joseph Edelman 02/14/2025