X0407 4 2023-05-19 0 0001484565 SOLENO THERAPEUTICS INC SLNO 0001224962 PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 0 0 1 0 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 0 0 1 0 0001164426 EDELMAN JOSEPH 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 0 0 1 0 0 Common Stock 2023-05-19 4 P 0 25200 4.62 A 1889655 I See footnotes Common Stock 2023-05-22 4 P 0 27300 5.12 A 1916955 I See footnotes Common Stock 2023-05-23 4 P 0 27500 5.45 A 1944455 I See footnotes The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $4.50 to $4.84, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges of the prices reported. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.00 to $5.161, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges of the prices reported. The price reported is a weighted average price. These shares were purchased in multiple transactions at prices ranging from $5.396 to $5.4739, inclusive. The Reporting Persons undertake to provide to the Issuer, any security holder of the Issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares purchased at each separate price within the ranges of the prices reported. The securities are directly held by Perceptive Life Sciences Master Fund Ltd. (the "Master Fund"). Perceptive Advisors LLC (the "Advisor") serves as the investment manager of Master Fund. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. /s/ Perceptive Advisors LLC, By: Joseph Edelman, its managing member 2023-05-23 /s/ Perceptive Life Science Master Fund, Ltd By: Joseph Edelman, its managing member 2023-05-23 /s/ Joseph Edelman 2023-05-23