X0306 4 2020-05-05 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001224962 PERCEPTIVE ADVISORS LLC C/O PERCEPTIVE ADVISORS, LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 0001249675 PERCEPTIVE LIFE SCIENCES MASTER FUND LTD C/O PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 0 0 1 0 0001797811 Perceptive LS (A), LLC C/O PERCEPTIVE ADVISORS, LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 0 0 1 0 0001164426 EDELMAN JOSEPH C/O PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 Common Stock 2020-05-05 4 P 0 625000 16.00 A 1934115 I See footnote Common Stock 1288446 I See footnote The securities reported in this row are held by Perceptive Life Sciences Master Fund, Ltd. (the "Master Fund"). The securities reported in this row are held by Perceptive LS (A), LLC ("Perceptive LS"). Perceptive Advisors, LLC (the "Advisor") serves as the investment advisor to the Master Fund. Perceptive LS GP, LLC ("GP") is the manager of Perceptive LS. Joseph Edelman is the managing member of the Advisor and the sole member of GP. Each of Mr. Edelman, GP and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that Mr. Edelman, GP or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. Perceptive Life Sciences Master Fund, Ltd. 2020-05-29 Perceptive LS (A), LLC 2020-05-29 /s/ Joseph Edelman 2020-05-29 Perceptive Advisors, LLC 2020-05-29