X0306 4 2020-04-30 0 0001327273 Lyra Therapeutics, Inc. LYRA 0001224962 PERCEPTIVE ADVISORS LLC C/O PERCEPTIVE ADVISORS, LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 0001164426 EDELMAN JOSEPH C/O PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 Stock Option 16.00 2020-04-30 4 A 0 14500 0.00 A 2030-04-29 Common Stock 14500 14500 I See footnotes Stock Option 16.00 2020-04-30 4 A 0 14500 0.00 A 2030-04-29 Common Stock 14500 14500 I See footnotes This option vests and becomes exercisable in 36 equal monthly installments beginning May 30, 2020. Consists of options to purchase shares of the Issuer's common stock awarded to Konstantin Poukalov in connection with his role as a member of the Issuer's Board of Directors. Mr. Poukalov is affiliated with Perceptive Advisors, LLC (the "Advisor"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase common stock of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Poukalov's board service through a partial management fee offset. Consists of options to purchase shares of the Issuer's common stock awarded to Michael Altman in connection with his role as a member of the Issuer's Board of Directors. Mr. Altman is affiliated with the Advisor. The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase common stock of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Mr. Altman's board service through a partial management fee offset. Joseph Edelman is the managing member of the Advisor. Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of the securities reported on this form, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. /s/ Joseph Edelman 2020-05-01 Perceptive Advisors, LLC 2020-05-01