X0306 4 2019-06-19 0 0001735438 MeiraGTx Holdings plc MGTX 0001224962 PERCEPTIVE ADVISORS LLC 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 1 0 1 0 0001164426 EDELMAN JOSEPH 51 ASTOR PLACE, 10TH FLOOR NEW YORK NY 10003 0 0 1 0 Stock Option (right to buy) 21.28 2019-06-19 4 A 0 25000 0.00 A 2029-06-10 Ordinary Shares 25000 25000 I See Footnotes The option shall vest and become exercisable in a single annual installment upon the earlier of (i) June 19, 2020 or (ii) the day immediately prior to the date of the Issuer's annual meeting of shareholders in 2020. Consists of options to purchase shares of the Issuer's common stock awarded to Ellen Hukkelhoven in connection with her role as a member of the Issuer's Board of Directors. Ms. Hukkelhoven a Managing Director of Perceptive Advisors, LLC (the "Advisor"). The Advisor may be deemed to have an indirect pecuniary interest in the options to purchase common stock of the Issuer reported herein because the Advisor has the right to receive the director compensation provided in respect of Ms. Hukkelhoven's board service through a partial management fee offset. Joseph Edelman is the managing member of the Advisor. (continued from footnote 2) Each of Mr. Edelman and the Advisor disclaims, for purposes of Section 16 of the Securities Exchange Act of 1934, beneficial ownership of such securities, except to the extent of his/its indirect pecuniary interest therein, and this report shall not be deemed an admission that either Mr. Edelman or the Advisor is the beneficial owner of such securities for purposes of Section 16 or for any other purposes. /s/ Perceptive Advisors LLC, By: Joseph Edelman, its managing member 2019-06-21 /s/ Joseph Edelman 2019-06-21