Stockholders' Equity and Redeemable Convertible Preferred Stock (Details 2) - Stock Option [Member] $ / shares in Units, $ in Thousands	6 Months Ended
	Jun. 30, 2016 USD ($) $ / shares shares
Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Outstanding at beginning | shares	286,487
Options granted | shares	19,735
Outstanding at ending | shares	306,222
Options vested and expected to vest | shares	306,222
Options vested and exercisable | shares	294,384
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Outstanding at beginning | $ / shares	$ 89.07
Options granted | $ / shares	1.98
Outstanding at ending | $ / shares	83.46
Options vested and expected to vest | $ / shares	83.46
Options vested and exercisable | $ / shares	$ 86.72
Share-based Compensation Arrangement by Share-based Payment Award, Options, Intrinsic Value [Roll Forward]
Outstanding at beginning | $
Options granted | $	7,894
Outstanding at ending | $	7,894
Options vested and expected to vest | $	7,894
Options vested and exercisable | $	$ 3,948
Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Life [Roll Forward]
Outstanding at beginning	5 years
Options granted	4 years 9 months 18 days
Outstanding at ending	4 years 6 months
Options vested and expected to vest	4 years 6 months
Options vested and exercisable	4 years 6 months
Non-Employee [Member]
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding [Roll Forward]
Outstanding at beginning | shares	2,893
Options granted | shares
Outstanding at ending | shares	2,893
Options vested and expected to vest | shares	2,893
Options vested and exercisable | shares	2,893
Share-based Compensation Arrangement by Share-based Payment Award, Options, Outstanding, Weighted Average Exercise Price [Roll Forward]
Outstanding at beginning | $ / shares	$ 98.07
Options granted | $ / shares
Outstanding at ending | $ / shares	98.07
Options vested and expected to vest | $ / shares	98.07
Options vested and exercisable | $ / shares	$ 98.07
Share-based Compensation Arrangement by Share-based Payment Award, Options, Intrinsic Value [Roll Forward]
Outstanding at beginning | $
Options granted | $
Outstanding at ending | $
Options vested and expected to vest | $
Options vested and exercisable | $
Share-based Compensation Arrangement by Share-based Payment Award, Options, Weighted Average Remaining Contractual Life [Roll Forward]
Outstanding at beginning	5 years 4 months 24 days
Outstanding at ending	4 years 10 months 24 days
Options vested and expected to vest	4 years 10 months 24 days
Options vested and exercisable	4 years 10 months 24 days