144 0001222644 XXXXXXXX LIVE 0001699031 GRAIL, Inc. 001-42045 1525 O'Brien Dr. Menlo Park CA 94025 415-528-0644 Robert Ragusa Officer Director Common Stock ETRADE FINANCIAL CORPORATION

3 EDISON DRIVE ALPHARETTA GA 30005

8275 573374.75 36313808 10/15/2025 NASDAQ Common Stock 06/28/2024 Shares acquired upon vesting of restricted stock units awarded under Issuer's equity incentive plans Issuer N 14170 10/14/2025 Services rendered Y Represents an estimate of shares expected to be sold to cover tax obligations upon vesting of restricted stock units on October 14, 2025, based on an estimated price per share of $69.29, which was the closing price of a share of the Company's common stock on October 14, 2025. 10/14/2025 /s/Donald Lang, as Attorney-in-Fact for Robert Ragusa