X0306 4 2019-02-15 0 0001299130 PACIFIC BIOSCIENCES OF CALIFORNIA, INC. PACB 0001222643 ORDONEZ KATHY PACIFIC BIOSCIENCES OF CALIFORNIA, INC. 1305 O'BRIEN DRIVE MENLO PARK CA 94025 1 0 0 0 Common Stock 2019-02-15 4 A 0 19950 0.00 A 63700 D Common Stock 2019-02-19 4 S 0 6933 7.168 D 56767 D Represents the number of shares earned upon satisfaction of performance goals in connection with performance-based restricted stock units. Represents the number of shares automatically sold to cover tax withholding obligations in connection with the vesting of restricted stock units and performance awards. This sale price represents the weighted average sale price of the shares sold ranging from $7.16 to $7.18 per share. Upon request by the Commission staff, the Issuer, or a security holder of the Issuer, the Reporting Person will provide full information regarding the number of shares sold at each separate price within the range set forth in this Form 4. /s/ Stephen Moore, Attorney-in-fact for Kathy Ordonez 2019-02-20