X0206 3 2015-08-26 0 0000805928 AxoGen, Inc. AXGN 0001222362 NEELS GUIDO J 21 WATERWAY AVENUE, SUITE 225 THE WOODLANDS TX 77380 1 0 1 0 Common Stock 4861111 I Essex Woodlands Fund IX, L.P. Stock Option (Right to Buy) 3.80 2022-08-26 Common Stock 25000 D The reporting person is a managing director of the entity that is the general partner of the general partner of the partnership that owns the reported securities. The reporting person disclaims beneficial ownership of the reported securities except to the extent of his pecuniary interest therein. Option grant for joining the Issuer's Board of Directors. Options vest as to 12.5% of total share amount at the end of each fiscal quarter, becoming fully vested after two years. /s/ Guido J. Neels 2015-09-02