X0508 4 2025-11-24 0001604821 Natera, Inc. NTRA 0001222287 BOTHA ROELOF 2800 SAND HILL ROAD, SUITE 101 MENLO PARK CA 94025 1 0 0 0 0 Common Stock 2025-11-24 4 S 0 2000 228.9672 D 1227198 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 1000 230.0300 D 1226198 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 900 231.2335 D 1225298 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 3606 232.7533 D 1221692 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 7032 233.6601 D 1214660 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 9991 234.5512 D 1204669 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 9623 235.6512 D 1195046 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 6173 236.5380 D 1188873 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 15336 237.6930 D 1173537 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 18839 238.5699 D 1154698 I Estate planning vehicles Common Stock 2025-11-24 4 S 0 500 239.1100 D 1154198 I Estate planning vehicles Common Stock 2428 D The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $228.70 to $229.63. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. Includes 4,411 shares transferred to an estate planning vehicle in a transaction exempt from Section 16 pursuant to Rule 16a-13. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $230.00 to $230.05. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $231.04 to $231.83. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $232.09 to $233.08. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $233.09 to $234.08. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $234.09 to $235.08. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $235.09 to $236.08. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $236.09 to $237.08. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $237.09 to $238.08. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. The price reported in column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $238.09 to $239.07. The Reporting Person undertakes to provide the Issuer, any security holder of the Issuer, or the staff at the Securities and Exchange Commission, upon request, the full information regarding the number of shares sold at each separate price within the ranges set forth above. By: /s/ Jung Yeon Son, by power of attorney for Roelof F. Botha 2025-11-26