X0202 3 2007-05-24 0 0001274563 HELICOS BIOSCIENCES CORP HLCS 0001222012 AFEYAN NOUBAR C/O FLAGSHIP VENTURES ONE MEMORIAL DRIVE, 7TH FLOOR CAMBRIDGE MA 02142 1 0 1 0 0001255927 KANIA EDWIN M JR C/O FLAGSHIP VENTURES ONE MEMORIAL DRIVE, 7TH FLOOR CAMBRIDGE 02142 0 0 1 0 0001399781 NewcoGen Elan LLC C/O FLAGSHIP VENTURES ONE MEMORIAL DRIVE, 7TH FLOOR CAMBRIDGE MA 02142 0 0 1 0 0001097546 NEWCOGEN EQUITY INVESTORS LLC C/O FLAGSHIP VENTURES CAMBRIDGE MA 02142 0 0 1 0 0001097548 NEWCOGEN GROUP LLC C/O FLAGSHIP VENTURES ONE MEMORIAL DRIVE, 7TH FLOOR CAMBRIDGE MA 02142 0 0 1 0 0001400241 NewcoGen Group, Inc. C/O FLAGSHIP VENTURES ONE MEMORIAL DRIVE, 7TH FLOOR CAMBRIDGE MA 02142 0 0 1 0 0001399783 NewcoGen PE LLC C/O FLAGSHIP VENTURES ONE MEMORIAL DRIVE, 7TH FLOOR CAMBRIDGE MA 02142 0 0 1 0 0001399780 ST NewcoGen LLC C/O FLAGSHIP VENTURES ONE MEMORIAL DRIVE, 7TH FLOOR CAMBRIDGE 02142 0 0 1 0 Common Stock 120123 D Series A Redeemable Convertible Preferred Stock Common Stock 1495076 I See footnote Series B Redeemable Convertible Preferred Stock Common Stock 1491598 I See footnote These shares are held directly by NewcoGen Group, LLC. The preferred stock is convertible at any time, at the holder's election, on a 4.5-for-one basis and has no expiration date. The preferred stock will automtaically convert upon the closing of the issuer's initial public offering, on a 4.5-for-one basis. Consists of 66,281 shares held by AGTC Advisors Fund, L.P. ("AGTC"), 1,096,557 shares held by Applied Genomic Technology Capital Fund, L.P. ("AGTC Fund" and together with AGTC, the "AGTC Funds"), 28,492 shares held by NewcoGen Elan LLC ("NewcoGen Elan"), 145,473 shares held by NewcoGen Equity Investors LLC ("NewcoGen Equity"), 116,160 shares held by NewcoGen Group, LLC ("NewcoGen Group"), 30,305 shares held by NewcoGen PE LLC ("NewcoGen PE"), 5,920 shares held by NewcoGen Long Reign Holding LLC ("NewcoGen Long Reign") and 5,888 shares of ST NewcoGen LLC ("ST NewcoGen" together with NewcoGen Elan, NewcoGen Equity, NewcoGen Group, NewcoGen PE and NewcoGen Long Reign, the "NewcoGen Funds"). NewcoGen Group, Inc. ("NewcoGen Inc.") is the manager of each of the NewcoGen Funds and the general partner of AGTC Partners, L.P. which is the general partner of each of AGTC Funds. NewcoGen Inc. is a wholly owned subsidiary Flagship Ventures Management, Inc. ("Flagship Inc.") Flagship Ventures General Partner LLC ("Flagship LLC") is the general partner of Flagship Ventures Fund 2004, L.P. Noubar B. Afeyan PhD and Edwin M. Kania, Jr. are the directors of Flagship Inc. and managers of Flagship LLC and may be deemed to share voting and investment power with respect to all shares held by the NewcoGen Funds, Flagship and the AGTC Funds. Each of Dr. Afeyan and Mr. Kania disclaim beneficial ownership of such shares except to the extent of any pecuniary interest therein. Consists of 40,056 shares held by AGTC, 662,678 shares held by AGTC Fund, 702,734 shares held by Flagship, 11,356 shares held by NewcoGen Elan, 57,988 shares held by NewcoGen Equity, 12,080 shares held by NewcoGen PE, 2,360 shares held by NewcoGen Long Reign and 2,346 shares of ST NewcoGen. /s/ Noubar B. Afeyan, Managing Partner 2007-05-24 /s/ Noubar B. Afeyan, Managing Partner 2007-05-24 /s/ Noubar B. Afeyan, Managing Partner 2007-05-24 /s/ Noubar B. Afeyan, Managing Partner 2007-05-24 /s/ Noubar B. Afeyan, Managing Partner 2007-05-24 /s/ Noubar B. Afeyan, Managing Partner 2007-05-24 /s/ Edwin M. Kania 2007-05-24 /s/ Noubar B. Afeyan 2007-05-24