X0306 4 2021-11-11 0000012208 BIO-RAD LABORATORIES, INC. BIO BIOB 0001717996 TUMOLO ANNETTE C/O BIO-RAD LABORATORIES, INC. 1000 ALFRED NOBEL DRIVE HERCULES CA 94547 0 1 0 0 Executive Vice President Bio-Rad A Common Stock 2021-11-11 4 M 0 613 333.34 A 5206.3476 D Bio-Rad A Common Stock 2021-11-11 4 M 0 500 333.34 A 5706.3476 D Bio-Rad A Common Stock 2021-11-11 4 M 0 433 524.30 A 6139.3476 D Bio-Rad A Common Stock 2021-11-11 4 S 0 433 748.08 D 5706.3476 D Bio-Rad A Common Stock 2021-11-11 4 S 0 613 748.84 D 5093.3476 D Bio-Rad A Common Stock 2021-11-11 4 S 0 500 750.00 D 4593.3476 D Bio-Rad A Common Stock 2021-11-12 4 M 0 600 159.32 A 5193.3476 D Bio-Rad A Common Stock 2021-11-12 4 M 0 2400 215.98 A 7593.3476 D Bio-Rad A Common Stock 2021-11-12 4 M 0 1800 326.15 A 9393.3476 D Bio-Rad A Common Stock 2021-11-12 4 S 0 4800 750.05 D 4593.3476 D Non-Qualified Stock Option (right to buy) 524.30 2021-11-11 4 M 0 433 0 D 2030-09-02 Bio-Rad A Common Stock 433 1300 D Non-Qualified Stock Option (right to buy) 333.34 2021-11-11 4 M 0 1113 0 D 2029-09-03 Bio-Rad A Common Stock 1113 1671 D Non-Qualified Stock Option (right to buy) 326.15 2021-11-12 4 M 0 1800 0 D 2028-09-04 Bio-Rad A Common Stock 1800 1200 D Non-Qualified Stock Option (right to buy) 215.98 2021-11-12 4 M 0 2400 0 D 2027-09-05 Bio-Rad A Common Stock 2400 600 D Non-Qualified Stock Option (right to buy) 159.32 2021-11-12 4 M 0 600 0 D 2026-09-07 Bio-Rad A Common Stock 600 0 D The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $750.00 to $750.61, inclusive. The reporting person undertakes to provide to Bio-Rad Laboratories, Inc., any security holder of Bio-Rad Laboratories, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option, representing a right to purchase a total of 1,733 shares, became exercisable in four equal annual installments beginning on September 2, 2021, which was the first anniversary of the date on which the option was granted. The option, representing a right to purchase a total of 2,784 shares, became exercisable in five equal annual installments beginning on September 3, 2020, which was the first anniversary of the date on which the option was granted. The option, representing a right to purchase a total of 3,000 shares, became exercisable in five equal annual installments beginning on September 4, 2019, which was the first anniversary of the date on which the option was granted. The option, representing a right to purchase a total of 3,000 shares, became exercisable in five equal annual installments beginning on September 5, 2018, which was the first anniversary of the date on which the option was granted. The option, representing a right to purchase a total of 3,000 shares, became exercisable in five equal annual installments beginning on September 7, 2017, which was the first anniversary of the date on which the option was granted. /s/ Annette Tumolo 2021-11-12