X0202 4 2004-10-01 0 0000729922 OSI PHARMACEUTICALS INC OSIP 0001220049 ONETTO NICOLE C/O OSI PHARMACEUTICALS, INC. 58 SOUTH SERVICE ROAD, SUITE 110 MELVILLE NY 11747 0 1 0 0 Exec.VP& Chief Medical Officer Common Stock 2004-10-01 4 M 0 798 21.55 A 5053 D Common Stock 2004-10-01 4 M 0 2300 30.74 A 7353 D Common Stock 2004-10-01 4 S 0 49 60.75 D 7304 D Common Stock 2004-10-01 4 S 0 48 60.76 D 7256 D Common Stock 2004-10-01 4 S 0 28 60.77 D 7228 D Common Stock 2004-10-01 4 S 0 14 60.78 D 7214 D Common Stock 2004-10-01 4 S 0 69 60.80 D 7145 D Common Stock 2004-10-01 4 S 0 28 60.81 D 7117 D Common Stock 2004-10-01 4 S 0 15 60.83 D 7102 D Common Stock 2004-10-01 4 S 0 1387 60.96 D 5715 D Common Stock 2004-10-01 4 S 0 323 61.00 D 5392 D Common Stock 2004-10-01 4 S 0 42 61.05 D 5350 D Common Stock 2004-10-01 4 S 0 55 61.07 D 5295 D Common Stock 2004-10-01 4 S 0 40 61.09 D 5255 D Common Stock 2004-10-01 4 S 0 362 61.10 D 4893 D Common Stock 2004-10-01 4 S 0 14 61.11 D 4879 D Common Stock 2004-10-01 4 S 0 55 61.18 D 4824 D Common Stock 2004-10-01 4 S 0 14 61.19 D 4810 D Common Stock 2004-10-01 4 S 0 14 61.25 D 4796 D Common Stock 2004-10-01 4 S 0 55 61.30 D 4741 D Common Stock 2004-10-01 4 S 0 111 61.55 D 4630 D Common Stock 2004-10-01 4 S 0 222 61.60 D 4408 D Common Stock 2004-10-01 4 S 0 28 61.75 D 4380 D Common Stock 2004-10-01 4 S 0 125 61.83 D 4255 D Stock Option (Right to Buy) 21.55 2004-10-01 4 M 0 798 0.00 D 2003-06-12 2012-06-11 Common Stock 798 6372 D Stock Option (Right to Buy) 30.74 2004-10-01 4 M 0 2300 0.00 D 2004-06-25 2013-06-24 Common Stock 2300 46000 D The transactions reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. One third of the stock option became exercisable one year after the date of the grant and the remainder vested ratably on a monthly basis over the succeeding 24 months. The stock option was granted pursuant to one of the Issuer's incentive and non-qualified stock option plans and is exempt under Rule 16b-3. Includes only options with the same termination date. Robert L. Van Nostrand by Power of Attorney 2004-10-05