X0306 4 2017-10-12 0 0001616543 Senseonics Holdings, Inc. SENS 0001219855 BARRETT M JAMES 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 1 0 1 0 Common Stock 2017-10-12 4 A 0 3250 0.00 A 497939 D Common Stock 21911183 I See Note 1 Common Stock 152079 I By Wife The Reporting Person is a general partner of NEA Partners 10, Limited Partnership ("NEA Partners 10"). NEA Partners 10 is the sole general partner of New Enterprise Associates 10, Limited Partnership ("NEA 10"), the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the Securities Exchange Act of 1934, as amended, or otherwise of such portion of the NEA 10 shares in which the Reporting Person has no pecuniary interest. /s/ Sasha Keough, attorney-in-fact 2017-10-16