X0306 4 2020-09-18 0 0001634379 Metacrine, Inc. MTCR 0001605598 ARCH Venture Fund VIII, L.P. 8755 WEST HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001617237 ARCH Venture Fund VIII Overage, L.P. 8755 WEST HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001219039 CRANDELL KEITH 8755 WEST HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001219043 BYBEE CLINTON 8755 WEST HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001219042 NELSEN ROBERT 8755 WEST HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001616165 ARCH Venture Partners VIII, LLC 8755 WEST HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 0001616176 ARCH Venture Partners VIII, L.P. 8755 WEST HIGGINS ROAD, SUITE 1025 CHICAGO IL 60631 0 0 1 0 Common Stock 2020-09-18 4 C 0 1960784 A 1960784 I See footnote Common Stock 2020-09-18 4 C 0 472251 A 2433035 I See footnote Common Stock 2020-09-18 4 C 0 138734 A 2571769 I See footnote Common Stock 2020-09-18 4 P 0 210000 13.00 A 2781769 I See footnote Common Stock 2020-09-18 4 C 0 138734 A 138734 I See footnote Common Stock 2020-09-18 4 P 0 20000 13.00 A 158734 I See footnote Series A Convertible Preferred Stock 2020-09-18 4 C 0 1960784 D Common Stock 1960784 0 I See footnote Series B Convertible Preferred Stock 2020-09-18 4 C 0 472251 D Common Stock 472251 0 I See footnote Series C Convertible Preferred Stock 2020-09-18 4 C 0 138734 D Common Stock 138734 0 I See footnote Series C Convertible Preferred Stock 2020-09-18 4 C 0 138734 D Common Stock 138734 0 I See footnote Every 5.1 shares of Series A Convertible Preferred Stock, Series B Convertible Preferred Stock and Series C Convertible Preferred Stock (the "Preferred Stock") automatically converted into 1 share of Common Stock upon the closing of the Issuer's initial public offering. Share numbers give effect to such conversion. The Preferred Stock had no expiration date. These shares are directly held by ARCH Venture Fund VIII, L.P., or ARCH Fund VIII. The sole general partner of ARCH Fund VIII is ARCH Venture Partners VIII, L.P., or ARCH Partners VIII, which may be deemed to beneficially own the shares held by ARCH Fund VIII. The sole general partner of ARCH Partners VIII is ARCH Venture Partners VIII, LLC, or ARCH VIII LLC, which may be deemed to beneficially own the shares held by ARCH Fund VIII. ARCH Partners VIII and ARCH VIII LLC disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein. The managing directors of ARCH VIII LLC are Keith L. Crandell, Clinton Bybee and Robert Nelsen, and they may be deemed to beneficially own the shares held by ARCH Fund VIII. Messrs. Crandell, Bybee and Nelsen disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein. These shares are directly held by ARCH Venture Fund VIII Overage, L.P., or ARCH Fund Overage. The sole general partner of ARCH Fund Overage is ARCH VIII LLC, which may be deemed to beneficially own the shares held by ARCH Fund Overage. ARCH VIII LLC disclaims beneficial ownership of such shares, except to the extent of any pecuniary interest therein. The managing directors of ARCH VIII LLC are Keith L. Crandell, Clinton Bybee and Robert Nelsen, and they may be deemed to beneficially own the shares held by ARCH Fund Overage. Messrs. Crandell, Bybee and Nelsen disclaim beneficial ownership of such shares, except to the extent of any pecuniary interest therein. ARCH Venture Fund VIII, L.P. By: ARCH Venture Partners VIII, L.P. its General Partner By: ARCH Venture Partners VIII, LLC. its General Partner By: /s/ Mark McDonnell as Attorney-in-Fact for Keith Crandell, Managing Director 2020-09-22 ARCH Venture Fund VIII Overage, L.P., ARCH Venture Partners VIII, LLC, its General Partner By: /s/ Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director 2020-09-22 Keith Crandell, Managing Director By: /s/ Mark McDonnell, as Attorney-in-Fact 2020-09-22 Clinton Bybee, Managing Director By: /s/ Mark McDonnell, as Attorney-in-Fact 2020-09-22 Robert Nelsen, Managing Director By: /s/ Mark McDonnell, as Attorney-in-Fact 2020-09-22 ARCH Venture Partners VIII, LLC By: /s/ Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director 2020-09-22 ARCH Venture Partners VIII, L.P. By: ARCH Venture Partners VIII, LLC, its General Partner By: /s/ Mark McDonnell, as Attorney-in-Fact for Keith Crandell, Managing Director 2020-09-22