X0202 4 2007-07-25 0000912183 CUBIST PHARMACEUTICALS INC CBST 0001219021 GUIFFRE CHRISTOPHERD T 65 HAYDEN AVENUE LEXINGTON MA 02421 0 1 0 0 Senior Vice President Common Stock 2007-07-25 4 M 0 20000 10.84 A 24976 D Common Stock 2007-07-25 4 S 0 250 22.68 D 24726 D Common Stock 2007-07-25 4 S 0 1497 22.69 D 23229 D Common Stock 2007-07-25 4 S 0 800 22.7 D 22429 D Common Stock 2007-07-25 4 S 0 200 22.71 D 22229 D Common Stock 2007-07-25 4 S 0 300 22.73 D 21929 D Common Stock 2007-07-25 4 S 0 100 22.74 D 21829 D Common Stock 2007-07-25 4 S 0 1800 22.75 D 20029 D Common Stock 2007-07-25 4 S 0 226 22.75 D 19803 D Common Stock 2007-07-25 4 S 0 380 22.76 D 19423 D Common Stock 2007-07-25 4 S 0 220 22.8 D 19203 D Common Stock 2007-07-25 4 S 0 9 22.86 D 19194 D Common Stock 2007-07-25 4 S 0 1100 22.87 D 18094 D Common Stock 2007-07-25 4 S 0 2090 22.88 D 16004 D Common Stock 2007-07-25 4 S 0 200 22.9 D 15804 D Common Stock 2007-07-25 4 S 0 3200 22.91 D 12604 D Common Stock 2007-07-25 4 S 0 1600 22.92 D 11004 D Common Stock 2007-07-25 4 S 0 1354 22.93 D 9650 D Common Stock 2007-07-25 4 S 0 700 22.94 D 8950 D Common Stock 2007-07-25 4 S 0 300 22.95 D 8650 D Common Stock 2007-07-25 4 S 0 500 22.96 D 8150 D Common Stock 2007-07-25 4 S 0 300 22.97 D 7850 D Common Stock 2007-07-25 4 S 0 100 22.98 D 7750 D Common Stock 2007-07-25 4 S 0 1700 23 D 6050 D Common Stock 2007-07-25 4 S 0 500 23.01 D 5550 D Common Stock 2007-07-25 4 S 0 100 23.03 D 5450 D Common Stock 2007-07-25 4 S 0 700 23.04 D 4750 D Stock Options (Right to buy) 10.84 2007-07-25 4 M 0 20000 0 D 2004-10-01 2014-07-01 Common Stock 20000 10000 D Sold pursuant to a Rule 10(b)5-1 Plan Christopher D.T. Guiffre 2007-07-26