X0202 4 2007-01-31 0000912183 CUBIST PHARMACEUTICALS INC CBST 0001219021 GUIFFRE CHRISTOPHERD T 65 HAYDEN AVENUE LEXINGTON MA 02421 0 1 0 0 Senior Vice President Common Stock 2007-01-31 4 M 0 10000 9.25 A 15346 D Common Stock 2007-01-31 4 S 0 100 17.9 D 15246 D Common Stock 2007-01-31 4 S 0 301 17.92 D 14945 D Common Stock 2007-01-31 4 S 0 200 17.93 D 14745 D Common Stock 2007-01-31 4 S 0 144 17.94 D 14601 D Common Stock 2007-01-31 4 S 0 755 17.95 D 13846 D Common Stock 2007-01-31 4 S 0 200 17.96 D 13646 D Common Stock 2007-01-31 4 S 0 100 17.97 D 13546 D Common Stock 2007-01-31 4 S 0 1100 17.99 D 12446 D Common Stock 2007-01-31 4 S 0 900 18 D 11546 D Common Stock 2007-01-31 4 S 0 200 18.01 D 11346 D Common Stock 2007-01-31 4 S 0 1300 18.02 D 10046 D Common Stock 2007-01-31 4 S 0 300 18.03 D 9746 D Common Stock 2007-01-31 4 S 0 300 18.04 D 9446 D Common Stock 2007-01-31 4 S 0 500 18.05 D 8946 D Common Stock 2007-01-31 4 S 0 1700 18.06 D 7246 D Common Stock 2007-01-31 4 S 0 200 18.07 D 7046 D Common Stock 2007-01-31 4 S 0 300 18.08 D 6746 D Common Stock 2007-01-31 4 S 0 200 18.09 D 6546 D Common Stock 2007-01-31 4 S 0 200 18.1 D 6346 D Common Stock 2007-01-31 4 S 0 100 18.11 D 6246 D Common Stock 2007-01-31 4 S 0 1091 18.12 D 5155 D Common Stock 2007-01-31 4 S 0 600 18.15 D 4555 D Common Stock 2007-01-31 4 S 0 300 18.16 D 4255 D Stock Options (Right to buy) 9.25 2007-01-31 4 M 0 10000 0 D 2003-08-13 2013-05-13 Common Stock 10000 15000 D Sold pursuant to a Rule 10(b)5-1 Plan Christopher D Guiffre 2007-02-01