144 0001218802 XXXXXXXX LIVE 0001459839 SI-BONE, INC. 001-38701 471 El Camino Real, Suite 101 Santa Clara CA 95050 4082070700 DAVID & LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003 Director Officer Common Morgan Stanley Smith Barney LLC Executive Financial Services

1 New York Plaza 8th Floor New York NY 10004

38006 736176.22 44818575 10/12/2026 NASDAQ Common 05/15/2021 Restricted Stock Units Issuer N 38006 05/15/2021 N/A N 10b5-1 Sales for DAVID & LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003

471 El Camino Real, Suite 101 Santa Clara CA 95050

Common 08/24/2026 25972 522595.60 10b5-1 Sales for DAVID & LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003

471 El Camino Real, Suite 101 Santa Clara CA 95050

Common 08/21/2026 3923 78556.90 10b5-1 Sales for DAVID & LAURA FRANCIS JOINT REV TRU/A DTD 01/03/2003

471 El Camino Real, Suite 101 Santa Clara CA 95050

Common 08/20/2026 51884 1009558.87 LAURA FRANCIS

471 El Camino Real, Suite 101 Santa Clara CA 95050

Common 08/17/2026 14956 279064.67 The securities to be sold were acquired upon the vesting of restricted stock units during the period of 5/15/2021 through 11/15/2025. Sales that were executed on October 12, 2026 are being reported on this Form 144 filed on October 13, 2026 given the EDGAR system was not accepting filings on October 12, 2026 in observance of the federal holiday. 10/12/2026 05/21/2026 /s/ Laura Francis