X0306 4 2012-11-13 0000859737 HOLOGIC INC HOLX 0001218713 CASCELLA ROBERT 35 CROSBY DRIVE BEDFORD MA 01730 1 1 CEO and President Common Stock 2012-11-13 4 F 0 9487 20.25 D 300458 D Common Stock 2012-11-14 4 A 0 48464 0 A 348922 D Common Stock 2012-11-14 4 A 0 51733 0 A 400655 D Common Stock 783 I By Spouse Non-qualified Stock Option (Right to Buy) 19.86 2012-11-14 4 A 0 404978 19.86 A 2013-11-14 2019-11-14 Common Stock 404978 404978 D The transaction reported herein reflects the disposition of 9,487 shares of common stock to satisfy tax withholding obligations in connection with the vesting of a portion of restricted stock units previously awarded to the Reporting Person on November 13, 2008. These shares represent restricted stock units (RSUs) awarded to the Reporting Person pursuant to the 2008 Equity Incentive Plan and are subject to vesting as provided in the agreement evidencing the award. These shares represent market stock units (MSUs) awarded to the Reporting Person pursuant to the 2008 Equity Incentive Plan and are subject to vesting as provided in the agreement evidencing the award. The option, issued pursuant to the 2008 Equity Incentive Plan, becomes exercisable in five equal annual installments beginning November 14, 2013. /s/ Mark J. Casey, Attorney-In-Fact for Robert A. Cascella 2012-11-15