X0306 4 2012-11-09 0000859737 HOLOGIC INC HOLX 0001218713 CASCELLA ROBERT 35 CROSBY DRIVE BEDFORD MA 01730 1 1 CEO and President Common Stock 2012-11-09 4 F 0 5352 20.32 D 322620 D Common Stock 2012-11-09 4 F 0 20 20.32 D 824 I By Spouse Common Stock 2012-11-10 4 F 0 4649 20.32 D 317971 D Common Stock 2012-11-10 4 F 0 24 20.32 D 800 I By Spouse Common Stock 2012-11-11 4 F 0 8026 20.32 D 309945 D Common Stock 2012-11-11 4 F 0 17 20.32 D 783 I By Spouse The transaction reported herein reflects the disposition of 5,352 shares of common stock to satisfy tax withholding obligations in connection with the vesting of a portion of restricted stock units previously awarded to the Reporting Person on November 9, 2011. The transaction reported herein reflects the disposition of 20 shares of common stock to satisfy tax withholding obligations in connection with the vesting of a portion of restricted stock units previously awarded to the Reporting Person's Spouse on November 9, 2011. The transaction reported herein reflects the disposition of 4,649 shares of common stock to satisfy tax withholding obligations in connection with the vesting of a portion of restricted stock units previously awarded to the Reporting Person on November 10, 2010. The transaction reported herein reflects the disposition of 24 shares of common stock to satisfy tax withholding obligations in connection with the vesting of a portion of restricted stock units previously awarded to the Reporting Person's Spouse on November 10, 2010. The transaction reported herein reflects the disposition of 8,026 shares of common stock to satisfy tax withholding obligations in connection with the vesting of a portion of restricted stock units previously awarded to the Reporting Person on November 11, 2009. The transaction reported herein reflects the disposition of 17 shares of common stock to satisfy tax withholding obligations in connection with the vesting of a portion of restricted stock units previously awarded to the Reporting Person's Spouse on November 11, 2009. /s/ Mark J. Casey, Attorney-In-Fact for Robert A. Cascella 2012-11-12