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Proc-Type: 2001,MIC-CLEAR
Originator-Name: webmaster@www.sec.gov
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 TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB
MIC-Info: RSA-MD5,RSA,
 FS6+WjRyaL5xbmkVcg7/agLRwMNi5HWO9BQb8FWE05os8EXR0yespVskyBA8FucM
 qa0Qrnl2zLuZSnRka1NIGQ==

<SEC-DOCUMENT>0000911420-04-000209.txt : 20040618
<SEC-HEADER>0000911420-04-000209.hdr.sgml : 20040618
<ACCEPTANCE-DATETIME>20040618160131
ACCESSION NUMBER:		0000911420-04-000209
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20040617
FILED AS OF DATE:		20040618

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			LAZAR MELVIN F
		CENTRAL INDEX KEY:			0001218403

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-09974
		FILM NUMBER:		04870914

	MAIL ADDRESS:	
		STREET 1:		300 EAST 56TH STREET
		STREET 2:		APT. 18A
		CITY:			NEW YORK
		STATE:			NY
		ZIP:			10022

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ENZO BIOCHEM INC
		CENTRAL INDEX KEY:			0000316253
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-MEDICAL LABORATORIES [8071]
		IRS NUMBER:				132866202
		STATE OF INCORPORATION:			NY
		FISCAL YEAR END:			0731

	BUSINESS ADDRESS:	
		STREET 1:		60 EXECUTIVE BLVD
		CITY:			FARMINGDALE
		STATE:			NY
		ZIP:			11735
		BUSINESS PHONE:		5167555500

	MAIL ADDRESS:	
		STREET 1:		ENZO BIOCHEM INC
		STREET 2:		60 EXECUTIVE BLVD
		CITY:			FARMINGDALE
		STATE:			NY
		ZIP:			11735
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>p955311_ex.xml
<TEXT>
<XML>
<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0202</schemaVersion>

    <documentType>4</documentType>

    <periodOfReport>2004-06-17</periodOfReport>

    <notSubjectToSection16>0</notSubjectToSection16>

    <issuer>
        <issuerCik>0000316253</issuerCik>
        <issuerName>ENZO BIOCHEM INC</issuerName>
        <issuerTradingSymbol>ENZ</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001218403</rptOwnerCik>
            <rptOwnerName>LAZAR MELVIN F</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>300 EAST 56TH STREET</rptOwnerStreet1>
            <rptOwnerStreet2>APT. 18A</rptOwnerStreet2>
            <rptOwnerCity>NEW YORK</rptOwnerCity>
            <rptOwnerState>NY</rptOwnerState>
            <rptOwnerZipCode>10022</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeTransaction>
            <securityTitle>
                <value>Common Stock, par value $01 per share</value>
            </securityTitle>
            <transactionDate>
                <value>2004-06-17</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>P</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
            </transactionCoding>
            <transactionAmounts>
                <transactionShares>
                    <value>7000</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>13.612</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>A</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>50375</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>See Footnote</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeTransaction>
    </nonDerivativeTable>

    <footnotes>
        <footnote id="F1">(1) The reporting person has a direct beneficial interest in 15,375 options which have been granted pursuant to Enzo
Biochem, Inc.'s 1999 Stock Option Plan, 6,000 shares held in a Defined Benefit Plan, 4,000 shares in an Individual
Retirement Account and an indirect beneficial interest in 18,000 shares which are directly beneficially owned by his spouse.

(2) The reporting person has an indirect beneficial interest in these shares which are directly beneficially owned by his
spouse.</footnote>
        <footnote id="F2">(1) The reporting person has a direct beneficial interest in 15,375 options which have been granted pursuant to Enzo
Biochem, Inc.'s 1999 Stock Option Plan, 6,000 shares held in a Defined Benefit Plan, 4,000 shares in an Individual
Retirement Account and an indirect beneficial interest in 18,000 shares which are directly beneficially owned by his spouse.

(2) The reporting person has an indirect beneficial interest in these shares which are directly beneficially owned by his
spouse.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Melvin F. Lazar</signatureName>
        <signatureDate>2004-06-17</signatureDate>
    </ownerSignature>
</ownershipDocument>

</XML>
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
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