X0306 4 2022-12-12 0 0001178711 Paratek Pharmaceuticals, Inc. PRTK 0001216917 BIGHAM MICHAEL C/O PARATEK PHARMACEUTICALS, INC. 75 PARK PLAZA, 4TH FLOOR BOSTON MA 02116 1 1 0 0 Exec. Chairman of the Board Common Stock 2022-12-12 4 S 0 19484 1.98 D 1212343 D Common Stock 2022-12-13 4 S 0 31891 1.96 D 1180452 D Sale of shares to cover personal income tax obligations upon vesting of restricted stock unit awards, pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions ranging from $1.96 to $2.00. The Reporting Person undertakes to provide to Paratek Pharmaceuticals, Inc., any security holder of Paratek Pharmaceuticals, Inc., or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote 2 to this Form 4. The price reported in Column 4 is a weighted average price. The shares were sold in multiple transactions ranging from $1.93 to $2.01. The Reporting Person undertakes to provide to Paratek Pharmaceuticals, Inc., any security holder of Paratek Pharmaceuticals, Inc., or the staff of the SEC, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote 3 to this Form 4. /s/ William M. Haskell, Attorney-in-Fact for Michael Bigham 2022-12-14